scholarly journals Reconstituted HDL: Drug Delivery Platform for Overcoming Biological Barriers to Cancer Therapy

2018 ◽  
Vol 9 ◽  
Author(s):  
Sangram Raut ◽  
Linda Mooberry ◽  
Nirupama Sabnis ◽  
Ashwini Garud ◽  
Akpedje Serena Dossou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Biological Barriers ◽  
Delivery Platform

scholarly journals Unlocking the Power of Exosomes for Crossing Biological Barriers in Drug Delivery

Pharmaceutics ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 122 ◽  
Author(s):  
Rebekah Omarkhail Elliott ◽  
Mei He
Keyword(s):  
Drug Delivery ◽  
Traffic Control ◽  
Information Transfer ◽  
Cancer Metastasis ◽  
Research Field ◽  
Blood Retinal Barrier ◽  
Biological Barriers ◽  
Diagnostic Role ◽  
Delivery Platform ◽  
Traffic Control System

Since the 2013 Nobel Prize was awarded for the discovery of vesicle trafficking, a subgroup of nanovesicles called exosomes has been driving the research field to a new regime for understanding cellular communication. This exosome-dominated traffic control system has increased understanding of many diseases, including cancer metastasis, diabetes, and HIV. In addition to the important diagnostic role, exosomes are particularly attractive for drug delivery, due to their distinctive properties in cellular information transfer and uptake. Compared to viral and non-viral synthetic systems, the natural, cell-derived exosomes exhibit intrinsic payload and bioavailability. Most importantly, exosomes easily cross biological barriers, obstacles that continue to challenge other drug delivery nanoparticle systems. Recent emerging studies have shown numerous critical roles of exosomes in many biological barriers, including the blood–brain barrier (BBB), blood–cerebrospinal fluid barrier (BCSFB), blood–lymph barrier (BlyB), blood–air barrier (BAB), stromal barrier (SB), blood–labyrinth barrier (BLaB), blood–retinal barrier (BRB), and placental barrier (PB), which opens exciting new possibilities for using exosomes as the delivery platform. However, the systematic reviews summarizing such discoveries are still limited. This review covers state-of-the-art exosome research on crossing several important biological barriers with a focus on the current, accepted models used to explain the mechanisms of barrier crossing, including tight junctions. The potential to design and engineer exosomes to enhance delivery efficacy, leading to future applications in precision medicine and immunotherapy, is discussed.

A cyanine-based polymeric nanoplatform with microenvironment-driven cascaded responsiveness for imaging-guided chemo-photothermal combination anticancer therapy

2020 ◽  
Vol 8 (10) ◽  
pp. 2115-2122 ◽  
Author(s):  
Xia Yang ◽  
Jinxia An ◽  
Zhong Luo ◽  
Rui Yang ◽  
Shuzhen Yan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Anticancer Therapy ◽  
Biological Barriers

Finding out how to overcome multistage biological barriers for nanocarriers in cancer therapy to obtain highly precise drug delivery is still a challenge.

Precise delivery of a multifunctional nanosystem for MRI-guided cancer therapy and monitoring of tumor response by functional diffusion-weighted MRI

2019 ◽  
Vol 7 (18) ◽  
pp. 2926-2937 ◽  
Author(s):  
Zeyu Xiao ◽  
Leung Chan ◽  
Dong Zhang ◽  
Cuiqing Huang ◽  
Chaoming Mei ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Mr Imaging ◽  
High Efficiency ◽  
Tumor Response ◽  
Diffusion Weighted Mri ◽  
Diffusion Weighted ◽  
Delivery Platform ◽  
Mri Guided ◽  
Cancer Theranostics

Herein we synthesize a cRGD peptide-conjugated PLGA nanosystem which is a high-efficiency drug-delivery platform for MR imaging-guided cancer theranostics.

Redox-Responsive Polyphosphate Nanosized Assemblies: A Smart Drug Delivery Platform for Cancer Therapy

2011 ◽  
Vol 12 (6) ◽  
pp. 2407-2415 ◽  
Author(s):  
Jinyao Liu ◽  
Yan Pang ◽  
Wei Huang ◽  
Zhaoyang Zhu ◽  
Xinyuan Zhu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Redox Responsive ◽  
Delivery Platform ◽  
Smart Drug ◽  
Smart Drug Delivery

pH/NIR-Responsive Polypyrrole-Functionalized Fibrous Localized Drug-Delivery Platform for Synergistic Cancer Therapy

2018 ◽  
Vol 10 (24) ◽  
pp. 20256-20270 ◽  
Author(s):  
Arjun Prasad Tiwari ◽  
Tae In Hwang ◽  
Jung-Mi Oh ◽  
Bikendra Maharjan ◽  
Sungkun Chun ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Delivery Platform ◽  
Localized Drug Delivery

Charge reversal induced colloidal hydrogel acts as a multi-stimuli responsive drug delivery platform for synergistic cancer therapy

2019 ◽  
Vol 6 (4) ◽  
pp. 711-716 ◽  
Author(s):  
Gang He ◽  
Sheng Chen ◽  
Yunjun Xu ◽  
Zhaohua Miao ◽  
Yan Ma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Stimuli Responsive ◽  
Gelatin Nanoparticles ◽  
Charge Reversal ◽  
Delivery Platform ◽  
A Charge

A charge reversal induced colloidal hydrogel composed of amphoteric gelatin nanoparticles (Gela NPs) and melanin-like polydopamine nanoparticles (PDA NPs) was developed for synergistic cancer therapy.

Self-Assembled Amphiphilic Starch Based Drug Delivery Platform: Synthesis, Preparation, and Interactions with Biological Barriers

2020 ◽  
Author(s):  
V. H. Giang Phan ◽  
Huu Thuy Trang Duong ◽  
Phu-Tri Tran ◽  
Thavasyappan Thambi ◽  
Duy-Khiet Ho ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biological Barriers ◽  
Delivery Platform ◽  
Self Assembled

Glutathione-responsive nanoscale MOFs for effective intracellular delivery of the anticancer drug 6-mercaptopurine

2020 ◽  
Vol 56 (47) ◽  
pp. 6448-6451 ◽  
Author(s):  
Ming Gong ◽  
Jian Yang ◽  
Yongsheng Li ◽  
Jinlou Gu
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Anticancer Drug ◽  
Disulfide Bonds ◽  
Intracellular Delivery ◽  
Delivery Platform

A glutathione-responsive drug-delivery platform based on nanoMOFs was developed for selective cancer therapy through the introduction of disulfide bonds.

Synthesis, characterization, and formulation of poly-puerarin as a biodegradable and biosafe drug delivery platform for anti-cancer therapy

2019 ◽  
Vol 7 (5) ◽  
pp. 2152-2164 ◽  
Author(s):  
Tianqi Yi ◽  
Jun Huang ◽  
Xuewen Chen ◽  
Haiyun Xiong ◽  
Yang Kang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Tumour Therapy ◽  
Anti Cancer ◽  
Delivery Platform

Poly-puerarin, a novel biodegradable biomaterial as a drug delivery platform in anti-tumour therapy.

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