Synthesis, characterization, and formulation of poly-puerarin as a biodegradable and biosafe drug delivery platform for anti-cancer therapy

2019 ◽  
Vol 7 (5) ◽  
pp. 2152-2164 ◽  
Author(s):  
Tianqi Yi ◽  
Jun Huang ◽  
Xuewen Chen ◽  
Haiyun Xiong ◽  
Yang Kang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Tumour Therapy ◽  
Anti Cancer ◽  
Delivery Platform

Poly-puerarin, a novel biodegradable biomaterial as a drug delivery platform in anti-tumour therapy.

scholarly journals Reconstituted HDL: Drug Delivery Platform for Overcoming Biological Barriers to Cancer Therapy

2018 ◽  
Vol 9 ◽  
Author(s):  
Sangram Raut ◽  
Linda Mooberry ◽  
Nirupama Sabnis ◽  
Ashwini Garud ◽  
Akpedje Serena Dossou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Biological Barriers ◽  
Delivery Platform

scholarly journals Enhanced penetrative siRNA delivery by a nanodiamond drug delivery platform against hepatocellular carcinoma 3D models

Nanoscale ◽  
2021 ◽  
Author(s):  
Jingru Xu ◽  
Mengjie Gu ◽  
Lissa Hooi ◽  
Tan Boon Toh ◽  
Dexter Kai Hao Thng ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Drug Delivery ◽  
Sirna Delivery ◽  
3D Models ◽  
Comprehensive Analysis ◽  
Gene Knockdown ◽  
Tumor Models ◽  
Anti Cancer ◽  
Delivery Platform

Comprehensive analysis of hepatocellular carcinoma 3D models revealed enhanced penetrative siRNA delivery by a nanodiamonds compared to liposomes. Nanodiamonds were able to improve siRNA's gene knockdown and anti-cancer effects in 3D tumor models.

scholarly journals Frontiers in Bioengineering and Biotechnology: Plant Nanoparticles for Anti-Cancer Therapy

Vaccines ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 830
Author(s):  
Erum Shoeb ◽  
Uzma Badar ◽  
Srividhya Venkataraman ◽  
Kathleen Hefferon
Keyword(s):  
Drug Delivery ◽  
Cancer Research ◽  
Cancer Therapy ◽  
Plant Virus ◽  
Biomedical Applications ◽  
Plant Viruses ◽  
Naturally Occurring ◽  
Anti Cancer ◽  
Diagnostic Agents ◽  
Stimuli Response

Naturally occurring viral nanomaterials have gained popularity owing to their biocompatible and biodegradable nature. Plant virus nanoparticles (VNPs) can be used as nanocarriers for a number of biomedical applications. Plant VNPs are inexpensive to produce, safe to administer and efficacious as treatments. The following review describes how plant virus architecture facilitates the use of VNPs for imaging and a variety of therapeutic applications, with particular emphasis on cancer. Examples of plant viruses which have been engineered to carry drugs and diagnostic agents for specific types of cancer are provided. The drug delivery system in response to the internal conditions is known as stimuli response, recently becoming more applicable using plant viruses based VNPs. The review concludes with a perspective of the future of plant VNPs and plant virus-like particles (VLPs) in cancer research and therapy.

scholarly journals A Promising Biocompatible Platform: Lipid-Based and Bio-Inspired Smart Drug Delivery Systems for Cancer Therapy

2018 ◽  
Vol 19 (12) ◽  
pp. 3859 ◽  
Author(s):  
Min Kim ◽  
Seung-Hae Kwon ◽  
Jung Choi ◽  
Aeju Lee
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery Systems ◽  
Controlled Drug Release ◽  
Research Area ◽  
Delivery Systems ◽  
Cancer Therapies ◽  
Smart Systems ◽  
Tumor Microenvironments ◽  
Anti Cancer

Designing new drug delivery systems (DDSs) for safer cancer therapy during pre-clinical and clinical applications still constitutes a considerable challenge, despite advances made in related fields. Lipid-based drug delivery systems (LBDDSs) have emerged as biocompatible candidates that overcome many biological obstacles. In particular, a combination of the merits of lipid carriers and functional polymers has maximized drug delivery efficiency. Functionalization of LBDDSs enables the accumulation of anti-cancer drugs at target destinations, which means they are more effective at controlled drug release in tumor microenvironments (TMEs). This review highlights the various types of ligands used to achieve tumor-specific delivery and discusses the strategies used to achieve the effective release of drugs in TMEs and not into healthy tissues. Moreover, innovative recent designs of LBDDSs are also described. These smart systems offer great potential for more advanced cancer therapies that address the challenges posed in this research area.

Precise delivery of a multifunctional nanosystem for MRI-guided cancer therapy and monitoring of tumor response by functional diffusion-weighted MRI

2019 ◽  
Vol 7 (18) ◽  
pp. 2926-2937 ◽  
Author(s):  
Zeyu Xiao ◽  
Leung Chan ◽  
Dong Zhang ◽  
Cuiqing Huang ◽  
Chaoming Mei ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Mr Imaging ◽  
High Efficiency ◽  
Tumor Response ◽  
Diffusion Weighted Mri ◽  
Diffusion Weighted ◽  
Delivery Platform ◽  
Mri Guided ◽  
Cancer Theranostics

Herein we synthesize a cRGD peptide-conjugated PLGA nanosystem which is a high-efficiency drug-delivery platform for MR imaging-guided cancer theranostics.

Redox-Responsive Polyphosphate Nanosized Assemblies: A Smart Drug Delivery Platform for Cancer Therapy

2011 ◽  
Vol 12 (6) ◽  
pp. 2407-2415 ◽  
Author(s):  
Jinyao Liu ◽  
Yan Pang ◽  
Wei Huang ◽  
Zhaoyang Zhu ◽  
Xinyuan Zhu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Redox Responsive ◽  
Delivery Platform ◽  
Smart Drug ◽  
Smart Drug Delivery

pH/NIR-Responsive Polypyrrole-Functionalized Fibrous Localized Drug-Delivery Platform for Synergistic Cancer Therapy

2018 ◽  
Vol 10 (24) ◽  
pp. 20256-20270 ◽  
Author(s):  
Arjun Prasad Tiwari ◽  
Tae In Hwang ◽  
Jung-Mi Oh ◽  
Bikendra Maharjan ◽  
Sungkun Chun ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Delivery Platform ◽  
Localized Drug Delivery

Charge reversal induced colloidal hydrogel acts as a multi-stimuli responsive drug delivery platform for synergistic cancer therapy

2019 ◽  
Vol 6 (4) ◽  
pp. 711-716 ◽  
Author(s):  
Gang He ◽  
Sheng Chen ◽  
Yunjun Xu ◽  
Zhaohua Miao ◽  
Yan Ma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Stimuli Responsive ◽  
Gelatin Nanoparticles ◽  
Charge Reversal ◽  
Delivery Platform ◽  
A Charge

A charge reversal induced colloidal hydrogel composed of amphoteric gelatin nanoparticles (Gela NPs) and melanin-like polydopamine nanoparticles (PDA NPs) was developed for synergistic cancer therapy.

A tumor-sensitive biological metal–organic complex for drug delivery and cancer therapy

2020 ◽  
Vol 8 (32) ◽  
pp. 7189-7196 ◽  
Author(s):  
Zelei Jiang ◽  
Tong Wang ◽  
Shuai Yuan ◽  
Mengfan Wang ◽  
Wei Qi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Cancer Therapy ◽  
Cancer Drug ◽  
Organic Complex ◽  
Anti Cancer ◽  
Metal Organic Complex ◽  
Metal Organic ◽  
Inhibition Of Tumor Growth

Tumor-sensitive bioMOC-Zn(Cys) was developed using an endogenous Zn2+ ion and l-cystine for the delivery of anti-cancer drug DOX. In vivo application of DOX@bioMOC-Zn(Cys) shows the increased inhibition of tumor growth and prevented side effects.

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