Precise delivery of a multifunctional nanosystem for MRI-guided cancer therapy and monitoring of tumor response by functional diffusion-weighted MRI

2019 ◽  
Vol 7 (18) ◽  
pp. 2926-2937 ◽  
Author(s):  
Zeyu Xiao ◽  
Leung Chan ◽  
Dong Zhang ◽  
Cuiqing Huang ◽  
Chaoming Mei ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Mr Imaging ◽  
High Efficiency ◽  
Tumor Response ◽  
Diffusion Weighted Mri ◽  
Diffusion Weighted ◽  
Delivery Platform ◽  
Mri Guided ◽  
Cancer Theranostics

Herein we synthesize a cRGD peptide-conjugated PLGA nanosystem which is a high-efficiency drug-delivery platform for MR imaging-guided cancer theranostics.

scholarly journals Reconstituted HDL: Drug Delivery Platform for Overcoming Biological Barriers to Cancer Therapy

2018 ◽  
Vol 9 ◽  
Author(s):  
Sangram Raut ◽  
Linda Mooberry ◽  
Nirupama Sabnis ◽  
Ashwini Garud ◽  
Akpedje Serena Dossou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Biological Barriers ◽  
Delivery Platform

Cucurbit[7]uril-functionalized magnetic nanoparticles for imaging-guided cancer therapy

2020 ◽  
Vol 8 (14) ◽  
pp. 2749-2753 ◽  
Author(s):  
Ludan Yue ◽  
Chen Sun ◽  
Cheryl H. T. Kwong ◽  
Ruibing Wang
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Cancer Therapy ◽  
Surface Functionalization ◽  
Targeted Drug Delivery ◽  
Functionalized Magnetic Nanoparticles ◽  
Targeted Drug ◽  
Mri Guided

Cucurbit[7]uril-anchored Fe3O4 nanoparticles allowed facile surface functionalization and MRI-guided targeted drug delivery for cancer therapy.

scholarly journals Rapidly Separable Micropillar Integrated Dissolving Microneedles

Pharmaceutics ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 581 ◽  
Author(s):  
Chung-ryong Jung ◽  
Shayan Fakhraei Lahiji ◽  
Youseong Kim ◽  
Hyeonjun Kim ◽  
Hyungil Jung
Keyword(s):  
Drug Delivery ◽  
Elastic Properties ◽  
Transdermal Delivery ◽  
Injury Risk ◽  
High Efficiency ◽  
Delivery Systems ◽  
Skin Injury ◽  
Dissolving Microneedles ◽  
Delivery Platform

Dissolving microneedle (DMN) patches were developed as efficient and patient-friendly transdermal delivery systems for biopharmaceuticals. However, recent studies have confirmed that the efficiency of DMNs to deliver biopharmaceuticals is highly reduced because of incomplete insertion caused by the stiffness and elastic properties of the skin. Therefore, micropillar integrated DMNs were developed to overcome the insertion limitations of DMN patches. Although micropillars were designed as integrated applicators to implant DMNs across the skin, they can also become inserted into the skin, leading to skin injury and inflammation. Herein, we have developed a separable micropillar integrated DMN (SPDMN) capable of inserting DMNs across the skin with high efficiency while minimizing skin injury risk through the introduction of a safety ring feature. Unlike previously developed systems, the SPDMN does not require continuous skin attachment and can be detached immediately post-application, leaving DMNs implanted inside the skin. Altogether, the findings of this study lead to the development of a quick, safe, and efficient DMN-based drug delivery platform.

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