Glutathione-responsive nanoscale MOFs for effective intracellular delivery of the anticancer drug 6-mercaptopurine

2020 ◽  
Vol 56 (47) ◽  
pp. 6448-6451 ◽  
Author(s):  
Ming Gong ◽  
Jian Yang ◽  
Yongsheng Li ◽  
Jinlou Gu
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Anticancer Drug ◽  
Disulfide Bonds ◽  
Intracellular Delivery ◽  
Delivery Platform

A glutathione-responsive drug-delivery platform based on nanoMOFs was developed for selective cancer therapy through the introduction of disulfide bonds.

scholarly journals Reconstituted HDL: Drug Delivery Platform for Overcoming Biological Barriers to Cancer Therapy

2018 ◽  
Vol 9 ◽  
Author(s):  
Sangram Raut ◽  
Linda Mooberry ◽  
Nirupama Sabnis ◽  
Ashwini Garud ◽  
Akpedje Serena Dossou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Biological Barriers ◽  
Delivery Platform

Micro/nanomachines: what is needed for them to become a real force in cancer therapy?

Nanoscale ◽  
2019 ◽  
Vol 11 (14) ◽  
pp. 6519-6532 ◽  
Author(s):  
Lucie Reinišová ◽  
Soňa Hermanová ◽  
Martin Pumera
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Anticancer Drug ◽  
Future Development ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Anticancer Drug Delivery

A biomedical perspective is used to assess micro/nanomotor-based anticancer drug delivery systems with recommendations for their effective future development.

scholarly journals Anticancer drug nanomicelles formed by self-assembling amphiphilic dendrimer to combat cancer drug resistance

2015 ◽  
Vol 112 (10) ◽  
pp. 2978-2983 ◽  
Author(s):  
Tuo Wei ◽  
Chao Chen ◽  
Juan Liu ◽  
Cheng Liu ◽  
Paola Posocco ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Anticancer Drug ◽  
Delivery System ◽  
Drug Carrier ◽  
Drug Loading ◽  
Cancer Drug ◽  
Self Assembling

Drug resistance and toxicity constitute challenging hurdles for cancer therapy. The application of nanotechnology for anticancer drug delivery is expected to address these issues and bring new hope for cancer treatment. In this context, we established an original nanomicellar drug delivery system based on an amphiphilic dendrimer (AmDM), which could generate supramolecular micelles to effectively encapsulate the anticancer drug doxorubicin (DOX) with high drug-loading capacity (>40%), thanks to the unique dendritic structure creating large void space for drug accommodation. The resulting AmDM/DOX nanomicelles were able to enhance drug potency and combat doxorubicin resistance in breast cancer models by significantly enhancing cellular uptake while considerably decreasing efflux of the drug. In addition, the AmDM/DOX nanoparticles abolished significantly the toxicity related to the free drug. Collectively, our studies demonstrate that the drug delivery system based on nanomicelles formed with the self-assembling amphiphilic dendrimer constitutes a promising and effective drug carrier in cancer therapy.

Nanoparticles and mesenchymal stem cells: a win-win alliance for anticancer drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (43) ◽  
pp. 36910-36922 ◽  
Author(s):  
Min Li ◽  
Fangrong Zhang ◽  
Kerong Chen ◽  
Cheng Wang ◽  
Yujie Su ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cancer Therapy ◽  
Anticancer Drug ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Anticancer Drug Delivery

Schematic illustration of the combination of NPs and MSCs drug delivery systems for cancer therapy.

Precise delivery of a multifunctional nanosystem for MRI-guided cancer therapy and monitoring of tumor response by functional diffusion-weighted MRI

2019 ◽  
Vol 7 (18) ◽  
pp. 2926-2937 ◽  
Author(s):  
Zeyu Xiao ◽  
Leung Chan ◽  
Dong Zhang ◽  
Cuiqing Huang ◽  
Chaoming Mei ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Mr Imaging ◽  
High Efficiency ◽  
Tumor Response ◽  
Diffusion Weighted Mri ◽  
Diffusion Weighted ◽  
Delivery Platform ◽  
Mri Guided ◽  
Cancer Theranostics

Herein we synthesize a cRGD peptide-conjugated PLGA nanosystem which is a high-efficiency drug-delivery platform for MR imaging-guided cancer theranostics.

Redox-Responsive Polyphosphate Nanosized Assemblies: A Smart Drug Delivery Platform for Cancer Therapy

2011 ◽  
Vol 12 (6) ◽  
pp. 2407-2415 ◽  
Author(s):  
Jinyao Liu ◽  
Yan Pang ◽  
Wei Huang ◽  
Zhaoyang Zhu ◽  
Xinyuan Zhu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Redox Responsive ◽  
Delivery Platform ◽  
Smart Drug ◽  
Smart Drug Delivery

Amphiphilic drug–drug assembly via dual-responsive linkages for small-molecule anticancer drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (71) ◽  
pp. 66420-66430 ◽  
Author(s):  
Tian Zhong ◽  
Ran Huang ◽  
Lianjiang Tan
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Anticancer Drug ◽  
Small Molecule ◽  
Disulfide Bonds ◽  
Anticancer Drug Delivery ◽  
Dual Responsive ◽  
Amphiphilic Drug

Amphiphilic drug–drug assembly nanoparticles based on dual-responsive H-bonding-instructed disulfide bonds can release irinotecan and doxorubicin simultaneously in cancer cells for anticancer purposes.

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