Self-Assembled Amphiphilic Starch Based Drug Delivery Platform: Synthesis, Preparation, and Interactions with Biological Barriers

2020 ◽  
Author(s):  
V. H. Giang Phan ◽  
Huu Thuy Trang Duong ◽  
Phu-Tri Tran ◽  
Thavasyappan Thambi ◽  
Duy-Khiet Ho ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biological Barriers ◽  
Delivery Platform ◽  
Self Assembled

scholarly journals Unlocking the Power of Exosomes for Crossing Biological Barriers in Drug Delivery

Pharmaceutics ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 122 ◽  
Author(s):  
Rebekah Omarkhail Elliott ◽  
Mei He
Keyword(s):  
Drug Delivery ◽  
Traffic Control ◽  
Information Transfer ◽  
Cancer Metastasis ◽  
Research Field ◽  
Blood Retinal Barrier ◽  
Biological Barriers ◽  
Diagnostic Role ◽  
Delivery Platform ◽  
Traffic Control System

Since the 2013 Nobel Prize was awarded for the discovery of vesicle trafficking, a subgroup of nanovesicles called exosomes has been driving the research field to a new regime for understanding cellular communication. This exosome-dominated traffic control system has increased understanding of many diseases, including cancer metastasis, diabetes, and HIV. In addition to the important diagnostic role, exosomes are particularly attractive for drug delivery, due to their distinctive properties in cellular information transfer and uptake. Compared to viral and non-viral synthetic systems, the natural, cell-derived exosomes exhibit intrinsic payload and bioavailability. Most importantly, exosomes easily cross biological barriers, obstacles that continue to challenge other drug delivery nanoparticle systems. Recent emerging studies have shown numerous critical roles of exosomes in many biological barriers, including the blood–brain barrier (BBB), blood–cerebrospinal fluid barrier (BCSFB), blood–lymph barrier (BlyB), blood–air barrier (BAB), stromal barrier (SB), blood–labyrinth barrier (BLaB), blood–retinal barrier (BRB), and placental barrier (PB), which opens exciting new possibilities for using exosomes as the delivery platform. However, the systematic reviews summarizing such discoveries are still limited. This review covers state-of-the-art exosome research on crossing several important biological barriers with a focus on the current, accepted models used to explain the mechanisms of barrier crossing, including tight junctions. The potential to design and engineer exosomes to enhance delivery efficacy, leading to future applications in precision medicine and immunotherapy, is discussed.

scholarly journals Reconstituted HDL: Drug Delivery Platform for Overcoming Biological Barriers to Cancer Therapy

2018 ◽  
Vol 9 ◽  
Author(s):  
Sangram Raut ◽  
Linda Mooberry ◽  
Nirupama Sabnis ◽  
Ashwini Garud ◽  
Akpedje Serena Dossou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Biological Barriers ◽  
Delivery Platform

scholarly journals Self-Assembled Lipid−Polymer Hybrid Nanoparticles: A Robust Drug Delivery Platform

ACS Nano ◽  
2008 ◽  
Vol 2 (8) ◽  
pp. 1696-1702 ◽  
Author(s):  
Liangfang Zhang ◽  
Juliana M. Chan ◽  
Frank X. Gu ◽  
June-Wha Rhee ◽  
Andrew Z. Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hybrid Nanoparticles ◽  
Polymer Hybrid ◽  
Delivery Platform ◽  
Self Assembled

Self-Assembled Peptide–Lanthanide Nanoclusters for Safe Tumor Therapy: Overcoming and Utilizing Biological Barriers to Peptide Drug Delivery

ACS Nano ◽  
2018 ◽  
Vol 12 (2) ◽  
pp. 2017-2026 ◽  
Author(s):  
Jin Yan ◽  
Wangxiao He ◽  
Siqi Yan ◽  
Fan Niu ◽  
Tianya Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Therapy ◽  
Peptide Drug ◽  
Biological Barriers ◽  
Self Assembled

Self-assembled prodrugs: An enzymatically triggered drug-delivery platform

Biomaterials ◽  
2009 ◽  
Vol 30 (3) ◽  
pp. 383-393 ◽  
Author(s):  
Praveen K. Vemula ◽  
Gregory A. Cruikshank ◽  
Jeffrey M. Karp ◽  
George John
Keyword(s):  
Drug Delivery ◽  
Delivery Platform ◽  
Self Assembled

Fabrication of Layer-By-Layer Self-Assembled Drug Delivery Platform for Prednisolone

2013 ◽  
Vol 52 (15) ◽  
pp. 1637-1644 ◽  
Author(s):  
Ganesh B. Patil ◽  
Ketan P. Ramani ◽  
Abhijeet P. Pandey ◽  
Mahesh P. More ◽  
Pravin O. Patil ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Layer By Layer ◽  
Delivery Platform ◽  
Self Assembled

scholarly journals Bioreducible Micelles Self-Assembled from Poly(ethylene glycol)-Cholesteryl Conjugate As a Drug Delivery Platform

Polymers ◽  
2015 ◽  
Vol 7 (11) ◽  
pp. 2245-2258 ◽  
Author(s):  
Chulsu Baek ◽  
Tae-Lin Ha ◽  
Eunjoo Kim ◽  
Sang Jeong ◽  
Se Lee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Delivery Platform ◽  
Self Assembled ◽  
Poly Ethylene

Self-assembly of a metallo-peptide into a drug delivery system using a “switch on” displacement strategy

2018 ◽  
Vol 6 (48) ◽  
pp. 8228-8237 ◽  
Author(s):  
Priyadip Das ◽  
Ieshita Pan ◽  
Ehud Cohen ◽  
Meital Reches
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Self Assembly ◽  
Turn On ◽  
Delivery Platform ◽  
Self Assembled

Two newly designed tripeptides and their corresponding Cu2+ conjugates self-assemble into nanometric structures of different morphologies. These self-assembled metallo-peptide networks can serve as a drug delivery platform using a fluorescent-based "Turn-On" displacement strategy.

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