scholarly journals Novel alginate-enclosed chitosan–calcium phosphate-loaded iron-saturated bovine lactoferrin nanocarriers for oral delivery in colon cancer therapy

Nanomedicine ◽  
2012 ◽  
Vol 7 (10) ◽  
pp. 1521-1550 ◽  
Author(s):  
Jagat R Kanwar ◽  
Ganesh Mahidhara ◽  
Rupinder K Kanwar
Keyword(s):  
Colon Cancer ◽  
Calcium Phosphate ◽  
Cancer Therapy ◽  
Oral Delivery ◽  
Bovine Lactoferrin

5-Fluorouracil Loaded Orally Administered WGA-decorated Poly(lactic-co-glycolic acid) Nanoparticles for Treatment of Colorectal Cancer: In Vivo Evaluation

2020 ◽  
Vol 10 ◽  
Author(s):  
Aditya Nath Pandey ◽  
Kuldeep Rajpoot ◽  
Sunil K. Jain
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Oral Delivery ◽  
Wheat Germ ◽  
Glycolic Acid ◽  
Organ Distribution ◽  
In Vivo Evaluation ◽  
Distribution Study ◽  
Prolonged Retention

Background:: Several studies have suggested potential aptitude of polylactic-co-glycolic acid (PLGA)-derived nanoparticles (NPs) to improve the antitumor efficacy of anticancer drugs against colon cancer. Further, conjugation of lectins over the surface of the NPs may ameliorate interaction and thus enhance attachment of NPs with receptors. Objective:: The main goal of the study was to prepare and evaluate targeting potential (in vivo) of the optimized NPs against colorectal cancer. Methods:: The 5-fluorouracil (5-FU) loaded and wheat germ agglutinin (WGA)-conjugated PLGA-NPs (WFUNPs) were prepared and then they were evaluated in vivo for targeting aptitude of formulation using gamma scintigraphy after oral delivery. The WGA-conjugated and non-conjugated optimized NPs were compared for any significant results. Further, optimized formulations were also assessed for different parameters such as radiolabeling efficiency, sodium pertechnetate uptake, stability of NPs, and organ distribution study. Results:: Findings suggested prolonged retention of 99mTc-tagged WFUNPs in the colonic region after 24 h study. Eventually, the outcome from conjugated formulation revealed enhanced bioavailability of the drug in blood plasma for up to 24 h. Conclusion:: In conclusion, WGA-conjugation to NPs could improve the performance of the PLGA-NPs in the treatment of colorectal cancer.

scholarly journals PIK3C3 Inhibition Promotes Sensitivity to Colon Cancer Therapy by Inhibiting Cancer Stem Cells

Cancers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 2168
Author(s):  
Balawant Kumar ◽  
Rizwan Ahmad ◽  
Swagat Sharma ◽  
Saiprasad Gowrikumar ◽  
Mark Primeaux ◽  
...  
Keyword(s):  
Stem Cells ◽  
Colon Cancer ◽  
Cancer Therapy ◽  
Cancer Stem Cells ◽  
Side Population ◽  
Therapy Resistance ◽  
Fluorescent Reporter ◽  
Combination Treatments ◽  
Gsk 3Β ◽  
Resistance To Chemotherapy

Background: Despite recent advances in therapies, resistance to chemotherapy remains a critical problem in the clinical management of colorectal cancer (CRC). Cancer stem cells (CSCs) play a central role in therapy resistance. Thus, elimination of CSCs is crucial for effective CRC therapy; however, such strategies are limited. Autophagy promotes resistance to cancer therapy; however, whether autophagy protects CSCs to promote resistance to CRC-therapy is not well understood. Moreover, specific and potent autophagy inhibitors are warranted as clinical trials with hydroxychloroquine have not been successful. Methods: Colon cancer cells and tumoroids were used. Fluorescent reporter-based analysis of autophagy flux, spheroid and side population (SP) culture, and qPCR were done. We synthesized 36-077, a potent inhibitor of PIK3C3/VPS34 kinase, to inhibit autophagy. Combination treatments were done using 5-fluorouracil (5-FU) and 36-077. Results: The 5-FU treatment induced autophagy only in a subset of the treated colon cancer. These autophagy-enriched cells also showed increased expression of CSC markers. Co-treatment with 36-077 significantly improved efficacy of the 5-FU treatment. Mechanistic studies revealed that combination therapy inhibited GSK-3β/Wnt/β-catenin signaling to inhibit CSC population. Conclusion: Autophagy promotes resistance to CRC-therapy by specifically promoting GSK-3β/Wnt/β-catenin signaling to promote CSC survival, and 36-077, a PIK3C3/VPS34 inhibitor, helps promote efficacy of CRC therapy.

scholarly journals Magnetic gold nanoparticle-mediated small interference RNA silencing Bag-1 gene for colon cancer therapy

2015 ◽  
Vol 35 (2) ◽  
pp. 978-984 ◽  
Author(s):  
WENBAI HUANG ◽  
ZHAN'AO LIU ◽  
GUANZHOU ZHOU ◽  
AILING TIAN ◽  
NIANFENG SUN
Keyword(s):  
Colon Cancer ◽  
Cancer Therapy ◽  
Gold Nanoparticle ◽  
Rna Silencing ◽  
Small Interference Rna ◽  
Interference Rna

scholarly journals Pharmacological inhibition of USP7 promotes antitumor immunity and contributes to colon cancer therapy

2019 ◽  
Vol Volume 12 ◽  
pp. 609-617 ◽  
Author(s):  
Changqing Fu ◽  
Xiaojue Zhu ◽  
Peiqi Xu ◽  
Yonghao Li
Keyword(s):  
Colon Cancer ◽  
Cancer Therapy ◽  
Antitumor Immunity ◽  
Pharmacological Inhibition

Calcium phosphate-PEG-insulin-casein (CAPIC) particles as oral delivery systems for insulin

2004 ◽  
Vol 277 (1-2) ◽  
pp. 91-97 ◽  
Author(s):  
T Morçöl ◽  
P Nagappan ◽  
L Nerenbaum ◽  
A Mitchell ◽  
S.J.D Bell
Keyword(s):  
Calcium Phosphate ◽  
Oral Delivery ◽  
Delivery Systems ◽  
Oral Delivery Systems

Oral delivery of taurocholic acid linked heparin–docetaxel conjugates for cancer therapy

2013 ◽  
Vol 170 (1) ◽  
pp. 74-82 ◽  
Author(s):  
Zehedina Khatun ◽  
Md Nurunnabi ◽  
Gerald R. Reeck ◽  
Kwang Jae Cho ◽  
Yong-kyu Lee
Keyword(s):  
Cancer Therapy ◽  
Oral Delivery ◽  
Taurocholic Acid

Locked nucleic acid modified bi-specific aptamer-targeted nanoparticles carrying survivin antagonist towards effective colon cancer therapy

RSC Advances ◽  
2015 ◽  
Vol 5 (37) ◽  
pp. 29008-29016 ◽  
Author(s):  
Kislay Roy ◽  
Rupinder K. Kanwar ◽  
Chun Hei Antonio Cheung ◽  
Cassandra Lee Fleming ◽  
Rakesh N. Veedu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Nucleic Acid ◽  
Cancer Therapy ◽  
Cancer Cells ◽  
Locked Nucleic Acid ◽  
Targeted Nanoparticles ◽  
Target Cancer

EpCAM and nucleolin translocate into the cytoplasm and nucleus that facilitates enhanced uptake of nanocarrier to specifically target cancer cells.

Targeted delivery of miRNA-204-5p by PEGylated polymer nanoparticles for colon cancer therapy

Nanomedicine ◽  
2018 ◽  
Vol 13 (7) ◽  
pp. 769-785 ◽  
Author(s):  
Bo Zheng ◽  
Lu Chen ◽  
Chun-Chun Pan ◽  
Jian-Zhang Wang ◽  
Guang-Rong Lu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Therapy ◽  
Targeted Delivery ◽  
Polymer Nanoparticles
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