Oral delivery of taurocholic acid linked heparin–docetaxel conjugates for cancer therapy

2013 ◽  
Vol 170 (1) ◽  
pp. 74-82 ◽  
Author(s):  
Zehedina Khatun ◽  
Md Nurunnabi ◽  
Gerald R. Reeck ◽  
Kwang Jae Cho ◽  
Yong-kyu Lee
Nanoscale ◽  
2021 ◽  
Author(s):  
Qing Wang ◽  
Naijie Wei ◽  
Jingru Guo ◽  
Kai Feng ◽  
Jingwei Zhang ◽  
...  

Although artemisinin (ART) has shown initial promise in cancer therapy, its therapeutic efficacy is limited by its low tumor inhibitory efficacy and unfavorable distribution. Considering the important role of heme...


2007 ◽  
Vol 98 (7) ◽  
pp. 1107-1112 ◽  
Author(s):  
Li-Jun Jia ◽  
Dong-Ping Wei ◽  
Qi-Ming Sun ◽  
Yan Huang ◽  
Qiang Wu ◽  
...  

RSC Advances ◽  
2018 ◽  
Vol 8 (24) ◽  
pp. 13103-13111 ◽  
Author(s):  
Jing Zhang ◽  
Di Zhang ◽  
Xu Hu ◽  
Ruiling Liu ◽  
Zhonghao Li ◽  
...  

To overcome the drawbacks of cytarabine such as bad liposolubility and low bioavailability, we rationally designed a new cytarabine-based prodrug for oral cytarabine delivery, realizing significantly enhanced bioavailability for cancer therapy.


Author(s):  
Mingming Zhang ◽  
Jianqin Liang ◽  
Yanyu Yang ◽  
Huize Liang ◽  
Huaping Jia ◽  
...  

Oral cancer is an aggressive tumor that invades the local tissue and can cause metastasis and high mortality. Conventional treatment strategies, e.g., surgery, chemotherapy, and radiation therapy alone or in combinations, possess innegligible issues, and significant side and adverse effects for the clinical applications. Currently, targeting drug delivery is emerging as an effective approach for oral delivery of different therapeutics. Herein we provide a state-of-the-art review on the current progress of targeting drug delivery for oral cancer therapy. Variously oral delivery systems including polymeric/inorganic nanoparticles, liposomes, cyclodextrins, nanolipids, and hydrogels-based forms are emphasized and discussed, and biomimetic systems with respect to oral delivery like therapeutic vitamin, exosomes, proteins, and virus-like particles are also described with emphasis on the cancer treatment. A future perspective is also provided to highlight the existing challenges and possible resolution toward clinical translation of current oral cancer therapies.


2021 ◽  
Author(s):  
Jintong Liu ◽  
Jing Huang ◽  
Lei Zhang ◽  
Jianping Lei

We review the general principle of the design and functional modulation of nanoscaled MOF heterostructures, and biomedical applications in enhanced therapy.


2009 ◽  
pp. 090526005142032-9 ◽  
Author(s):  
Jinna Cao ◽  
Jukui Sun ◽  
Xiaoyu Wang ◽  
Xinran Li ◽  
Yingjie Deng

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