scholarly journals Pharmacological inhibition of USP7 promotes antitumor immunity and contributes to colon cancer therapy

2019 ◽  
Vol Volume 12 ◽  
pp. 609-617 ◽  
Author(s):  
Changqing Fu ◽  
Xiaojue Zhu ◽  
Peiqi Xu ◽  
Yonghao Li
Keyword(s):  
Colon Cancer ◽  
Cancer Therapy ◽  
Antitumor Immunity ◽  
Pharmacological Inhibition

scholarly journals PIK3C3 Inhibition Promotes Sensitivity to Colon Cancer Therapy by Inhibiting Cancer Stem Cells

Cancers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 2168
Author(s):  
Balawant Kumar ◽  
Rizwan Ahmad ◽  
Swagat Sharma ◽  
Saiprasad Gowrikumar ◽  
Mark Primeaux ◽  
...  
Keyword(s):  
Stem Cells ◽  
Colon Cancer ◽  
Cancer Therapy ◽  
Cancer Stem Cells ◽  
Side Population ◽  
Therapy Resistance ◽  
Fluorescent Reporter ◽  
Combination Treatments ◽  
Gsk 3Β ◽  
Resistance To Chemotherapy

Background: Despite recent advances in therapies, resistance to chemotherapy remains a critical problem in the clinical management of colorectal cancer (CRC). Cancer stem cells (CSCs) play a central role in therapy resistance. Thus, elimination of CSCs is crucial for effective CRC therapy; however, such strategies are limited. Autophagy promotes resistance to cancer therapy; however, whether autophagy protects CSCs to promote resistance to CRC-therapy is not well understood. Moreover, specific and potent autophagy inhibitors are warranted as clinical trials with hydroxychloroquine have not been successful. Methods: Colon cancer cells and tumoroids were used. Fluorescent reporter-based analysis of autophagy flux, spheroid and side population (SP) culture, and qPCR were done. We synthesized 36-077, a potent inhibitor of PIK3C3/VPS34 kinase, to inhibit autophagy. Combination treatments were done using 5-fluorouracil (5-FU) and 36-077. Results: The 5-FU treatment induced autophagy only in a subset of the treated colon cancer. These autophagy-enriched cells also showed increased expression of CSC markers. Co-treatment with 36-077 significantly improved efficacy of the 5-FU treatment. Mechanistic studies revealed that combination therapy inhibited GSK-3β/Wnt/β-catenin signaling to inhibit CSC population. Conclusion: Autophagy promotes resistance to CRC-therapy by specifically promoting GSK-3β/Wnt/β-catenin signaling to promote CSC survival, and 36-077, a PIK3C3/VPS34 inhibitor, helps promote efficacy of CRC therapy.

scholarly journals Magnetic gold nanoparticle-mediated small interference RNA silencing Bag-1 gene for colon cancer therapy

2015 ◽  
Vol 35 (2) ◽  
pp. 978-984 ◽  
Author(s):  
WENBAI HUANG ◽  
ZHAN'AO LIU ◽  
GUANZHOU ZHOU ◽  
AILING TIAN ◽  
NIANFENG SUN
Keyword(s):  
Colon Cancer ◽  
Cancer Therapy ◽  
Gold Nanoparticle ◽  
Rna Silencing ◽  
Small Interference Rna ◽  
Interference Rna

scholarly journals Mucin 4 mutation is associated with tumor mutation burden and promotes antitumor immunity in colon cancer patients

Aging ◽  
2021 ◽  
Author(s):  
Linglong Peng ◽  
Yang Li ◽  
Haitao Gu ◽  
Ling Xiang ◽  
Yongfu Xiong ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Patients ◽  
Antitumor Immunity ◽  
Tumor Mutation Burden ◽  
Mutation Burden

Locked nucleic acid modified bi-specific aptamer-targeted nanoparticles carrying survivin antagonist towards effective colon cancer therapy

RSC Advances ◽  
2015 ◽  
Vol 5 (37) ◽  
pp. 29008-29016 ◽  
Author(s):  
Kislay Roy ◽  
Rupinder K. Kanwar ◽  
Chun Hei Antonio Cheung ◽  
Cassandra Lee Fleming ◽  
Rakesh N. Veedu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Nucleic Acid ◽  
Cancer Therapy ◽  
Cancer Cells ◽  
Locked Nucleic Acid ◽  
Targeted Nanoparticles ◽  
Target Cancer

EpCAM and nucleolin translocate into the cytoplasm and nucleus that facilitates enhanced uptake of nanocarrier to specifically target cancer cells.

Targeted delivery of miRNA-204-5p by PEGylated polymer nanoparticles for colon cancer therapy

Nanomedicine ◽  
2018 ◽  
Vol 13 (7) ◽  
pp. 769-785 ◽  
Author(s):  
Bo Zheng ◽  
Lu Chen ◽  
Chun-Chun Pan ◽  
Jian-Zhang Wang ◽  
Guang-Rong Lu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Therapy ◽  
Targeted Delivery ◽  
Polymer Nanoparticles
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