Successes and Limitations of Targeted Cancer Therapy in Colon Cancer

2014 ◽  
pp. 36-50 ◽  
Author(s):  
Claus-Henning Köhne
Keyword(s):  
Colon Cancer ◽  
Cancer Therapy ◽  
Targeted Cancer Therapy

Targeted Cancer Therapy; Nanotechnology Approaches for Overcoming Drug Resistance

2015 ◽  
Vol 22 (11) ◽  
pp. 1335-1347 ◽  
Author(s):  
Yan Gao ◽  
Jacson Shen ◽  
Lara Milane ◽  
Francis Hornicek ◽  
Mansoor Amiji ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Cancer Therapy ◽  
Targeted Cancer Therapy

Biological Carrier Molecules of Radiopharmaceuticals for Molecular Cancer Imaging and Targeted Cancer Therapy

2014 ◽  
Vol 20 (32) ◽  
pp. 5218-5244 ◽  
Author(s):  
A. Aerts ◽  
N.R.E.N. Impens ◽  
M. Gijs ◽  
M. D'Huyvetter ◽  
H. Vanmarcke ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Cancer Imaging ◽  
Targeted Cancer Therapy

TEM8 Targeted Cancer Therapy

2011 ◽  
Vol 11 (10) ◽  
pp. 983-992 ◽  
Author(s):  
Arthur E. Frankel ◽  
Carol Carter ◽  
Shu-Ru Kuo ◽  
Jung-Hee Woo ◽  
Jeremy Mauldin ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Targeted Cancer Therapy

Novel Nanotechnology Approaches for Targeted Cancer Therapy

2014 ◽  
Vol 3 (2) ◽  
pp. 83-88 ◽  
Author(s):  
Maria Gazouli ◽  
Nikolitsa Nomikou ◽  
John F Callan ◽  
Efstathios P. Efstathopoulos
Keyword(s):  
Cancer Therapy ◽  
Targeted Cancer Therapy

Comparative radium-223 labeling with NOTA and DOTA-somatostatin derivatives for a potential use in targeted cancer therapy

2019 ◽  
Vol 72-73 ◽  
pp. S50-S51
Author(s):  
M. Riondato ◽  
S. Pastorino ◽  
V. Duce ◽  
E. Giovannini ◽  
A. Ciarmiello
Keyword(s):  
Cancer Therapy ◽  
Targeted Cancer Therapy ◽  
Radium 223 ◽  
Potential Use

Multicolor Two‐photon Nanosystem for Multiplexed Intracellular Imaging and Targeted Cancer Therapy

2021 ◽  
Author(s):  
Yong-Xiang Wu ◽  
Dailiang Zhang ◽  
Xiaoxiao Hu ◽  
Ruizi Peng ◽  
Junbin Li ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Targeted Cancer Therapy ◽  
Intracellular Imaging ◽  
Two Photon

scholarly journals PIK3C3 Inhibition Promotes Sensitivity to Colon Cancer Therapy by Inhibiting Cancer Stem Cells

Cancers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 2168
Author(s):  
Balawant Kumar ◽  
Rizwan Ahmad ◽  
Swagat Sharma ◽  
Saiprasad Gowrikumar ◽  
Mark Primeaux ◽  
...  
Keyword(s):  
Stem Cells ◽  
Colon Cancer ◽  
Cancer Therapy ◽  
Cancer Stem Cells ◽  
Side Population ◽  
Therapy Resistance ◽  
Fluorescent Reporter ◽  
Combination Treatments ◽  
Gsk 3Β ◽  
Resistance To Chemotherapy

Background: Despite recent advances in therapies, resistance to chemotherapy remains a critical problem in the clinical management of colorectal cancer (CRC). Cancer stem cells (CSCs) play a central role in therapy resistance. Thus, elimination of CSCs is crucial for effective CRC therapy; however, such strategies are limited. Autophagy promotes resistance to cancer therapy; however, whether autophagy protects CSCs to promote resistance to CRC-therapy is not well understood. Moreover, specific and potent autophagy inhibitors are warranted as clinical trials with hydroxychloroquine have not been successful. Methods: Colon cancer cells and tumoroids were used. Fluorescent reporter-based analysis of autophagy flux, spheroid and side population (SP) culture, and qPCR were done. We synthesized 36-077, a potent inhibitor of PIK3C3/VPS34 kinase, to inhibit autophagy. Combination treatments were done using 5-fluorouracil (5-FU) and 36-077. Results: The 5-FU treatment induced autophagy only in a subset of the treated colon cancer. These autophagy-enriched cells also showed increased expression of CSC markers. Co-treatment with 36-077 significantly improved efficacy of the 5-FU treatment. Mechanistic studies revealed that combination therapy inhibited GSK-3β/Wnt/β-catenin signaling to inhibit CSC population. Conclusion: Autophagy promotes resistance to CRC-therapy by specifically promoting GSK-3β/Wnt/β-catenin signaling to promote CSC survival, and 36-077, a PIK3C3/VPS34 inhibitor, helps promote efficacy of CRC therapy.

scholarly journals Immune Cell Membrane‐Coated Biomimetic Nanoparticles for Targeted Cancer Therapy

Small ◽  
2021 ◽  
pp. 2006484
Author(s):  
Fatemeh Oroojalian ◽  
Mohammad Beygi ◽  
Behzad Baradaran ◽  
Ahad Mokhtarzadeh ◽  
Mohammad‐Ali Shahbazi
Keyword(s):  
Cancer Therapy ◽  
Cell Membrane ◽  
Immune Cell ◽  
Targeted Cancer Therapy ◽  
Biomimetic Nanoparticles

Novel N-Methylated Cyclodepsipeptide Prodrugs for Targeted Cancer Therapy

2021 ◽  
Vol 64 (2) ◽  
pp. 991-1000
Author(s):  
Chunlei Wu ◽  
Zhehong Cheng ◽  
Danyi Lu ◽  
Ke Liu ◽  
Yulian Cheng ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Targeted Cancer Therapy
Sign in / Sign up

Export Citation Format

Share Document