scholarly journals Delivering anion transporters to lipid bilayers in water

2021 ◽  
Author(s):  
Daniel A. McNaughton ◽  
Tsz Ying (Teresa) To ◽  
Bryson A. Hawkins ◽  
David E. Hibbs ◽  
Philip A. Gale
Keyword(s):  
Organic Solvent ◽  
Lipid Bilayers ◽  
Anion Transporters ◽  
Lipophilic Anion

Cyclodextrins have been employed as delivery agents for lipophilic anion transporters, which allow their incorporation into lipid bilayers without using an organic solvent or pre-incorporation.

scholarly journals Delivering anion transporters to lipid bilayers in water

2021 ◽  
Author(s):  
Daniel A. McNaughton ◽  
Tsz Ying (Teresa) To ◽  
Bryson A. Hawkins ◽  
David E. Hibbs ◽  
Philip Alan Gale
Keyword(s):  
Organic Solvent ◽  
Lipid Bilayers ◽  
Anion Transporters ◽  
Lipophilic Anion

CYCLODEXTRINS HAVE BEEN EMPLOYED AS DELIVERY AGENTS FOR LIPOPHILIC ANION TRANSPORTERS, WHICH ALLOW THEIR INCORPORATION INTO LIPID BILAYERS WITHOUT USING AN ORGANIC SOLVENT OR PRE-INCORPORATION.

scholarly journals Delivering anion transporters to lipid bilayers in water

2021 ◽  
Author(s):  
Daniel A. McNaughton ◽  
Tsz Ying (Teresa) To ◽  
Bryson A. Hawkins ◽  
David E. Hibbs ◽  
Philip Alan Gale
Keyword(s):  
Organic Solvent ◽  
Lipid Bilayers ◽  
Anion Transporters ◽  
Lipophilic Anion

CYCLODEXTRINS HAVE BEEN EMPLOYED AS DELIVERY AGENTS FOR LIPOPHILIC ANION TRANSPORTERS, WHICH ALLOW THEIR INCORPORATION INTO LIPID BILAYERS WITHOUT USING AN ORGANIC SOLVENT OR PRE-INCORPORATION.

Increasing membrane permeability of carboxylic acid-containing drugs using synthetic transmembrane anion transporters

2021 ◽  
Author(s):  
Rayhanus Salam ◽  
Surid Mohammad Chowdhury ◽  
Sarah Ruth Marshall ◽  
Hassan Gneid ◽  
Nathalie Busschaert
Keyword(s):  
Carboxylic Acid ◽  
Membrane Permeability ◽  
Lipid Bilayers ◽  
Small Molecule ◽  
Anion Transporters

In this manuscript, we show that small-molecule-based anion transporters can significantly increase the permeability of carboxylic acid containing drugs across lipid bilayers of model vesicles. Due to the drug-like characteristics...

scholarly journals Chloride Transport Across Planar Lipid Bilayers and Cell Membranes by Steriod-Based Synthetic Anion Transporters

2014 ◽  
Vol 106 (2) ◽  
pp. 188a-189a ◽  
Author(s):  
Hongyu Li ◽  
Germinal Magro ◽  
Luke W. Judd ◽  
Peter R. Brotherhood ◽  
David N. Sheppard ◽  
...  
Keyword(s):  
Lipid Bilayers ◽  
Cell Membranes ◽  
Chloride Transport ◽  
Planar Lipid Bilayers ◽  
Anion Transporters

Triaminopyrimidine derivatives as transmembrane HCl transporters

2019 ◽  
Vol 17 (22) ◽  
pp. 5633-5638 ◽  
Author(s):  
Petr Motloch ◽  
Ana Guerreiro ◽  
Carolina Q. Azeredo ◽  
Gonçalo J. L. Bernardes ◽  
Christopher A. Hunter ◽  
...  
Keyword(s):  
Lipid Bilayers ◽  
Proton Gradients ◽  
Anion Transporters

A series of triaminopyrimidine-based anion transporters has been described, capable of diminishing proton gradients across lipid bilayers at physiologically relevant pH.

scholarly journals Fluorinated synthetic anion carriers: experimental and computational insights into transmembrane chloride transport

2019 ◽  
Vol 10 (7) ◽  
pp. 1976-1985 ◽  
Author(s):  
Michael J. Spooner ◽  
Hongyu Li ◽  
Igor Marques ◽  
Pedro M. R. Costa ◽  
Xin Wu ◽  
...  
Keyword(s):  
Lipid Bilayers ◽  
Cell Membranes ◽  
Chloride Transport ◽  
Anion Transporters ◽  
Highly Active ◽  
Active Anion

A series of fluorinated tripodal tris-thioureas function as highly active anion transporters across lipid bilayers and cell membranes.

scholarly journals Aromatic isophthalamides aggregate in lipid bilayers: evidence for a cooperative transport mechanism

2015 ◽  
Vol 13 (10) ◽  
pp. 3136-3143 ◽  
Author(s):  
Stuart N. Berry ◽  
Nathalie Busschaert ◽  
Charlotte L. Frankling ◽  
Dale Salter ◽  
Philip A. Gale
Keyword(s):  
Transport Properties ◽  
Lipid Bilayers ◽  
Transport Mechanism ◽  
Anion Transport ◽  
Anion Transporters ◽  
Cooperative Transport

The synthesis and anion transport properties of a series of aromatic transmembrane anion transporters based on an isophthalamide scaffold are reported.

scholarly journals Thiosquaramides: pH switchable anion transporters

2014 ◽  
Vol 5 (9) ◽  
pp. 3617-3626 ◽  
Author(s):  
Nathalie Busschaert ◽  
Robert B. P. Elmes ◽  
Dawid D. Czech ◽  
Xin Wu ◽  
Isabelle L. Kirby ◽  
...  
Keyword(s):  
Transport Properties ◽  
Lipid Bilayers ◽  
Anion Transport ◽  
Anion Transporters ◽  
Ph Controlled

Thiosquaramides show pH controlled anion transport properties in lipid bilayers.

Observation of Concanavalin-A receptors on hydrated planar erythrocyte membrane film by in situ electron microscopy

1983 ◽  
Vol 41 ◽  
pp. 608-609
Author(s):  
Neng-Bo He ◽  
S.W. Hui
Keyword(s):  
Lipid Bilayers ◽  
Erythrocyte Membrane ◽  
Lipid Membranes ◽  
Surface Film ◽  
Biological Membranes ◽  
Electron Microscopic Observation ◽  
Electron Microscopic ◽  
Black Lipid Membranes ◽  
Fine Mesh ◽  
Planar Films

Monolayers and planar "black" lipid membranes have been widely used as models for studying the structure and properties of biological membranes. Because of the lack of a suitable method to prepare these membranes for electron microscopic observation, their ultrastructure is so far not well understood. A method of forming molecular bilayers over the holes of fine mesh grids was developed by Hui et al. to study hydrated and unsupported lipid bilayers by electron diffraction, and to image phase separated domains by diffraction contrast. We now adapted the method of Pattus et al. of spreading biological membranes vesicles on the air-water interfaces to reconstitute biological membranes into unsupported planar films for electron microscopic study. hemoglobin-free human erythrocyte membrane stroma was prepared by hemolysis. The membranes were spreaded at 20°C on balanced salt solution in a Langmuir trough until a surface pressure of 20 dyne/cm was reached. The surface film was repeatedly washed by passing to adjacent troughs over shallow partitions (fig. 1).

Effect of Integral Proteins on Frozen Membrane Fracture

1980 ◽  
Vol 38 ◽  
pp. 756-759 ◽  
Author(s):  
S. Kirchanski ◽  
D. Branton
Keyword(s):  
Lipid Bilayers ◽  
Freeze Fracture ◽  
Covalent Bond ◽  
Erythrocyte Membranes ◽  
Glycophorin A ◽  
Experimental Protocol ◽  
Transmembrane Glycoprotein ◽  
Bond Breakage ◽  
Human Erythrocyte Membranes ◽  
Integral Proteins

We have investigated the effect of integral membrane proteins upon the fracturing of frozen lipid bilayers. This investigation has been part of an effort to develop freeze fracture labeling techniques and to assess the possible breakage of covalent protein bonds during the freeze fracture process. We have developed an experimental protocol utilizing lectin affinity columns which should detect small amounts of covalent bond breakage during the fracture of liposomes containing purified (1) glycophorin (a transmembrane glycoprotein of human erythrocyte membranes). To fracture liposomes in bulk, frozen liposomes are ground repeatedly under liquid nitrogen. Failure to detect any significant covalent bond breakage (contrary to (2)) led us to question the effectiveness of our grinding procedure in fracturing and splitting lipid bilayers.

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