scholarly journals Thiosquaramides: pH switchable anion transporters

2014 ◽  
Vol 5 (9) ◽  
pp. 3617-3626 ◽  
Author(s):  
Nathalie Busschaert ◽  
Robert B. P. Elmes ◽  
Dawid D. Czech ◽  
Xin Wu ◽  
Isabelle L. Kirby ◽  
...  
Keyword(s):  
Transport Properties ◽  
Lipid Bilayers ◽  
Anion Transport ◽  
Anion Transporters ◽  
Ph Controlled

Thiosquaramides show pH controlled anion transport properties in lipid bilayers.

scholarly journals Aromatic isophthalamides aggregate in lipid bilayers: evidence for a cooperative transport mechanism

2015 ◽  
Vol 13 (10) ◽  
pp. 3136-3143 ◽  
Author(s):  
Stuart N. Berry ◽  
Nathalie Busschaert ◽  
Charlotte L. Frankling ◽  
Dale Salter ◽  
Philip A. Gale
Keyword(s):  
Transport Properties ◽  
Lipid Bilayers ◽  
Transport Mechanism ◽  
Anion Transport ◽  
Anion Transporters ◽  
Cooperative Transport

The synthesis and anion transport properties of a series of aromatic transmembrane anion transporters based on an isophthalamide scaffold are reported.

scholarly journals Coumarin-bisureas as potent fluorescent transmembrane anion transporters

2021 ◽  
Author(s):  
Mohamed Fares ◽  
Xin Wu ◽  
Daniel A. McNaughton ◽  
Alexander M. Gilchrist ◽  
William Lewis ◽  
...  
Keyword(s):  
Transport Properties ◽  
Lipid Bilayer ◽  
Anion Transport ◽  
Lipid Bilayer Membranes ◽  
Bilayer Membranes ◽  
Anion Transporters

A series of fluorescent coumarin bis-ureas have been synthesised and their anion transport properties studied. The compounds function as highly potent HCl co-transport agents in lipid bilayer membranes.

scholarly journals Fluorescent transmembrane anion transporters: shedding light on anionophoric activity in cells

2016 ◽  
Vol 7 (8) ◽  
pp. 5069-5077 ◽  
Author(s):  
Stuart N. Berry ◽  
Vanessa Soto-Cerrato ◽  
Ethan N. W. Howe ◽  
Harriet J. Clarke ◽  
Ishna Mistry ◽  
...  
Keyword(s):  
Transport Properties ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Anion Transport ◽  
Anion Transporters ◽  
In Cells

A series of fluorescent anion transporters have been synthesised and their anion transport properties and interactions with cancer cell lines studied.

scholarly journals Cation and anion transport through hydrophilic pores in lipid bilayers

2006 ◽  
Vol 125 (7) ◽  
pp. 074901 ◽  
Author(s):  
Senthil K. Kandasamy ◽  
Ronald G. Larson
Keyword(s):  
Lipid Bilayers ◽  
Anion Transport

scholarly journals Delivering anion transporters to lipid bilayers in water

2021 ◽  
Author(s):  
Daniel A. McNaughton ◽  
Tsz Ying (Teresa) To ◽  
Bryson A. Hawkins ◽  
David E. Hibbs ◽  
Philip Alan Gale
Keyword(s):  
Organic Solvent ◽  
Lipid Bilayers ◽  
Anion Transporters ◽  
Lipophilic Anion

CYCLODEXTRINS HAVE BEEN EMPLOYED AS DELIVERY AGENTS FOR LIPOPHILIC ANION TRANSPORTERS, WHICH ALLOW THEIR INCORPORATION INTO LIPID BILAYERS WITHOUT USING AN ORGANIC SOLVENT OR PRE-INCORPORATION.

Increasing membrane permeability of carboxylic acid-containing drugs using synthetic transmembrane anion transporters

2021 ◽  
Author(s):  
Rayhanus Salam ◽  
Surid Mohammad Chowdhury ◽  
Sarah Ruth Marshall ◽  
Hassan Gneid ◽  
Nathalie Busschaert
Keyword(s):  
Carboxylic Acid ◽  
Membrane Permeability ◽  
Lipid Bilayers ◽  
Small Molecule ◽  
Anion Transporters

In this manuscript, we show that small-molecule-based anion transporters can significantly increase the permeability of carboxylic acid containing drugs across lipid bilayers of model vesicles. Due to the drug-like characteristics...

scholarly journals Characterization of Guided Entry of Tail-Anchored Proteins 3 Homologues in Mycobacterium tuberculosis

2019 ◽  
Vol 201 (14) ◽  
Author(s):  
Kuan Hu ◽  
Ashley T. Jordan ◽  
Susan Zhang ◽  
Avantika Dhabaria ◽  
Amanda Kovach ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Structure Prediction ◽  
Bacterial Species ◽  
Normal Growth ◽  
Anion Transport ◽  
Content Type ◽  
Reading Frame ◽  
Anion Transporters ◽  
Anion Transporter

ABSTRACT We characterized an operon in Mycobacterium tuberculosis, Rv3679-Rv3680, in which each open reading frame is annotated to encode “anion transporter ATPase” homologues. Using structure prediction modeling, we found that Rv3679 and Rv3680 more closely resemble the guided entry of tail-anchored proteins 3 (Get3) chaperone in eukaryotes. Get3 delivers proteins into the membranes of the endoplasmic reticulum and is essential for the normal growth and physiology of some eukaryotes. We sought to characterize the structures of Rv3679 and Rv3680 and test if they have a role in M. tuberculosis pathogenesis. We solved crystal structures of the nucleotide-bound Rv3679-Rv3680 complex at 2.5 to 3.2 Å and show that while it has some similarities to Get3 and ArsA, there are notable differences, including that these proteins are unlikely to be involved in anion transport. Deletion of both genes did not reveal any conspicuous growth defects in vitro or in mice. Collectively, we identified a new class of proteins in bacteria with similarity to Get3 complexes, the functions of which remain to be determined. IMPORTANCE Numerous bacterial species encode proteins predicted to have similarity with Get3- and ArsA-type anion transporters. Our studies provide evidence that these proteins, which we named BagA and BagB, are unlikely to be involved in anion transport. In addition, BagA and BagB are conserved in all mycobacterial species, including the causative agent of leprosy, which has a highly decayed genome. This conservation suggests that BagAB constitutes a part of the core mycobacterial genome and is needed for some yet-to-be-determined part of the life cycle of these organisms.

scholarly journals Chloride Transport Across Planar Lipid Bilayers and Cell Membranes by Steriod-Based Synthetic Anion Transporters

2014 ◽  
Vol 106 (2) ◽  
pp. 188a-189a ◽  
Author(s):  
Hongyu Li ◽  
Germinal Magro ◽  
Luke W. Judd ◽  
Peter R. Brotherhood ◽  
David N. Sheppard ◽  
...  
Keyword(s):  
Lipid Bilayers ◽  
Cell Membranes ◽  
Chloride Transport ◽  
Planar Lipid Bilayers ◽  
Anion Transporters
Sign in / Sign up

Export Citation Format

Share Document