scholarly journals Aromatic isophthalamides aggregate in lipid bilayers: evidence for a cooperative transport mechanism

2015 ◽  
Vol 13 (10) ◽  
pp. 3136-3143 ◽  
Author(s):  
Stuart N. Berry ◽  
Nathalie Busschaert ◽  
Charlotte L. Frankling ◽  
Dale Salter ◽  
Philip A. Gale
Keyword(s):  
Transport Properties ◽  
Lipid Bilayers ◽  
Transport Mechanism ◽  
Anion Transport ◽  
Anion Transporters ◽  
Cooperative Transport

The synthesis and anion transport properties of a series of aromatic transmembrane anion transporters based on an isophthalamide scaffold are reported.

scholarly journals Thiosquaramides: pH switchable anion transporters

2014 ◽  
Vol 5 (9) ◽  
pp. 3617-3626 ◽  
Author(s):  
Nathalie Busschaert ◽  
Robert B. P. Elmes ◽  
Dawid D. Czech ◽  
Xin Wu ◽  
Isabelle L. Kirby ◽  
...  
Keyword(s):  
Transport Properties ◽  
Lipid Bilayers ◽  
Anion Transport ◽  
Anion Transporters ◽  
Ph Controlled

Thiosquaramides show pH controlled anion transport properties in lipid bilayers.

scholarly journals Coumarin-bisureas as potent fluorescent transmembrane anion transporters

2021 ◽  
Author(s):  
Mohamed Fares ◽  
Xin Wu ◽  
Daniel A. McNaughton ◽  
Alexander M. Gilchrist ◽  
William Lewis ◽  
...  
Keyword(s):  
Transport Properties ◽  
Lipid Bilayer ◽  
Anion Transport ◽  
Lipid Bilayer Membranes ◽  
Bilayer Membranes ◽  
Anion Transporters

A series of fluorescent coumarin bis-ureas have been synthesised and their anion transport properties studied. The compounds function as highly potent HCl co-transport agents in lipid bilayer membranes.

scholarly journals Fluorescent transmembrane anion transporters: shedding light on anionophoric activity in cells

2016 ◽  
Vol 7 (8) ◽  
pp. 5069-5077 ◽  
Author(s):  
Stuart N. Berry ◽  
Vanessa Soto-Cerrato ◽  
Ethan N. W. Howe ◽  
Harriet J. Clarke ◽  
Ishna Mistry ◽  
...  
Keyword(s):  
Transport Properties ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Anion Transport ◽  
Anion Transporters ◽  
In Cells

A series of fluorescent anion transporters have been synthesised and their anion transport properties and interactions with cancer cell lines studied.

scholarly journals Cation and anion transport through hydrophilic pores in lipid bilayers

2006 ◽  
Vol 125 (7) ◽  
pp. 074901 ◽  
Author(s):  
Senthil K. Kandasamy ◽  
Ronald G. Larson
Keyword(s):  
Lipid Bilayers ◽  
Anion Transport

scholarly journals Delivering anion transporters to lipid bilayers in water

2021 ◽  
Author(s):  
Daniel A. McNaughton ◽  
Tsz Ying (Teresa) To ◽  
Bryson A. Hawkins ◽  
David E. Hibbs ◽  
Philip Alan Gale
Keyword(s):  
Organic Solvent ◽  
Lipid Bilayers ◽  
Anion Transporters ◽  
Lipophilic Anion

CYCLODEXTRINS HAVE BEEN EMPLOYED AS DELIVERY AGENTS FOR LIPOPHILIC ANION TRANSPORTERS, WHICH ALLOW THEIR INCORPORATION INTO LIPID BILAYERS WITHOUT USING AN ORGANIC SOLVENT OR PRE-INCORPORATION.

scholarly journals Role of Liposomes Composite as Drug Transport Mechanism

2021 ◽  
pp. 230-243
Keyword(s):  
Drug Delivery ◽  
Lipid Bilayers ◽  
Transport Mechanism ◽  
Drug Transport ◽  
Phospholipid Bilayer ◽  
Drug Transporter ◽  
Delivery Methods ◽  
Second Stage ◽  
Novel Drug

Liposomes are spherical shaped vesicles comprising of at least one phospholipid bilayer that serve as a novel drug delivery framework. They are microscopic structures in which a fluid system is totally encased by a film made out of lipid bilayers. It varies in size, conformation, charge and drug transporter stacked with assortment of particles, for example, small molecules of drug, plasmids, nucleotides or proteins and so on. Ongoing advances in nanotherapeutics have brought about engineered liposomes rising in nanomedicine, giving better restorative control of diseased states. This has made ready for the improvement of second-stage liposomes for increased efficiency and could at last lead to a change in perspective from the regular drug delivery methods.

Increasing membrane permeability of carboxylic acid-containing drugs using synthetic transmembrane anion transporters

2021 ◽  
Author(s):  
Rayhanus Salam ◽  
Surid Mohammad Chowdhury ◽  
Sarah Ruth Marshall ◽  
Hassan Gneid ◽  
Nathalie Busschaert
Keyword(s):  
Carboxylic Acid ◽  
Membrane Permeability ◽  
Lipid Bilayers ◽  
Small Molecule ◽  
Anion Transporters

In this manuscript, we show that small-molecule-based anion transporters can significantly increase the permeability of carboxylic acid containing drugs across lipid bilayers of model vesicles. Due to the drug-like characteristics...

Importance of bicarbonate in bile salt independent fraction of bile flow.

1978 ◽  
Vol 235 (2) ◽  
pp. E158 ◽  
Author(s):  
W G Hardison ◽  
C A Wood
Keyword(s):  
Bile Salt ◽  
Bile Flow ◽  
Transport Mechanism ◽  
Excretion Rate ◽  
Organic Anion ◽  
Weak Acid ◽  
Anion Transport ◽  
Bicarbonate Transport ◽  
Canalicular Membrane ◽  
Bile Canalicular Membrane

The bile salt independent fraction (BSIF) of canalicular bile flow from the isolated rat liver perfused with bicarbonate-free perfusate is 50% of that from the liver perfused with bicarbonate-containing perfusate. HCO3-excretion is nearly eliminated and Na+ and Cl- excretion is reduced 50%. Replacement of HCO3- into perfusate increased bile flow by 0.3 microliter/g.min without changing bile acid excretion rate. 5.5-Dimethyl-2,4-oxazolidinedione (DMO) produced a similar effect. DMO was passively distributed between bile and plasma. The data indicate that a bicarbonate transport mechanism is responsible for production of up to 50% of the BSIF. Another weak acid, N-5[5-(2-methoxyethoxy)-2-pyrimidinyl]sulfamoylbenzene (glymidine), was rapidly excreted into bile and increased bile flow by over 2.0 microliter/g.min. Glymidine is probably excreted by an independent organic anion transport mechanism, and any effect on the bicarbonate transport mechanism is obscured. Canaliculus-enriched hepatocyte membrane fractions contained no HCO3-stimulated ATPase activity. Either this enzyme is unimportant in hepatocyte bicarbonate transport or transport occurs across membranes other than the bile canalicular membrane.

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