Increasing membrane permeability of carboxylic acid-containing drugs using synthetic transmembrane anion transporters

2021 ◽  
Author(s):  
Rayhanus Salam ◽  
Surid Mohammad Chowdhury ◽  
Sarah Ruth Marshall ◽  
Hassan Gneid ◽  
Nathalie Busschaert
Keyword(s):  
Carboxylic Acid ◽  
Membrane Permeability ◽  
Lipid Bilayers ◽  
Small Molecule ◽  
Anion Transporters

In this manuscript, we show that small-molecule-based anion transporters can significantly increase the permeability of carboxylic acid containing drugs across lipid bilayers of model vesicles. Due to the drug-like characteristics...

scholarly journals Delivering anion transporters to lipid bilayers in water

2021 ◽  
Author(s):  
Daniel A. McNaughton ◽  
Tsz Ying (Teresa) To ◽  
Bryson A. Hawkins ◽  
David E. Hibbs ◽  
Philip Alan Gale
Keyword(s):  
Organic Solvent ◽  
Lipid Bilayers ◽  
Anion Transporters ◽  
Lipophilic Anion

CYCLODEXTRINS HAVE BEEN EMPLOYED AS DELIVERY AGENTS FOR LIPOPHILIC ANION TRANSPORTERS, WHICH ALLOW THEIR INCORPORATION INTO LIPID BILAYERS WITHOUT USING AN ORGANIC SOLVENT OR PRE-INCORPORATION.

Interaction of Polycationic Polymers with Supported Lipid Bilayers and Cells:  Nanoscale Hole Formation and Enhanced Membrane Permeability

2006 ◽  
Vol 17 (3) ◽  
pp. 728-734 ◽  
Author(s):  
Seungpyo Hong ◽  
Pascale R. Leroueil ◽  
Elizabeth K. Janus ◽  
Jennifer L. Peters ◽  
Mary-Margaret Kober ◽  
...  
Keyword(s):  
Membrane Permeability ◽  
Lipid Bilayers ◽  
Supported Lipid Bilayers ◽  
Hole Formation ◽  
Polycationic Polymers

scholarly journals Small molecule‐facilitated anion transporters in cells for a novel therapeutic approach to cystic fibrosis

2019 ◽  
Vol 176 (11) ◽  
pp. 1764-1779 ◽  
Author(s):  
Michele Fiore ◽  
Claudia Cossu ◽  
Valeria Capurro ◽  
Cristiana Picco ◽  
Alessandra Ludovico ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Small Molecule ◽  
Therapeutic Approach ◽  
Anion Transporters ◽  
Novel Therapeutic ◽  
In Cells

scholarly journals Small molecule anion transporters display in vitro antimicrobial activity against clinically relevant bacterial strains

2019 ◽  
Vol 55 (68) ◽  
pp. 10080-10083 ◽  
Author(s):  
Israel Carreira-Barral ◽  
Carlos Rumbo ◽  
Marcin Mielczarek ◽  
Daniel Alonso-Carrillo ◽  
Enara Herran ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Small Molecule ◽  
Bacterial Strains ◽  
Antibiotic Resistant ◽  
In Vitro Antimicrobial Activity ◽  
Anion Transporters ◽  
Highly Active

Highly active transmembrane anion transporters have demonstrated their activity against antibiotic-resistant and clinically relevant bacterial strains.

Affordable Membrane Permeability Calculations: Permeation of Short-Chain Alcohols through Pure-Lipid Bilayers and a Mammalian Cell Membrane

2019 ◽  
Vol 15 (5) ◽  
pp. 2913-2924 ◽  
Author(s):  
Chi Hang Tse ◽  
Jeffrey Comer ◽  
Simon Kit Sang Chu ◽  
Yi Wang ◽  
Christophe Chipot
Keyword(s):  
Cell Membrane ◽  
Membrane Permeability ◽  
Lipid Bilayers ◽  
Mammalian Cell ◽  
Short Chain

scholarly journals Chloride Transport Across Planar Lipid Bilayers and Cell Membranes by Steriod-Based Synthetic Anion Transporters

2014 ◽  
Vol 106 (2) ◽  
pp. 188a-189a ◽  
Author(s):  
Hongyu Li ◽  
Germinal Magro ◽  
Luke W. Judd ◽  
Peter R. Brotherhood ◽  
David N. Sheppard ◽  
...  
Keyword(s):  
Lipid Bilayers ◽  
Cell Membranes ◽  
Chloride Transport ◽  
Planar Lipid Bilayers ◽  
Anion Transporters

Amyloid Aggregation on Lipid Bilayers and Its Impact on Membrane Permeability

2009 ◽  
Vol 387 (2) ◽  
pp. 407-415 ◽  
Author(s):  
Ran Friedman ◽  
Riccardo Pellarin ◽  
Amedeo Caflisch
Keyword(s):  
Membrane Permeability ◽  
Lipid Bilayers ◽  
Amyloid Aggregation
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