scholarly journals Fluorinated synthetic anion carriers: experimental and computational insights into transmembrane chloride transport

2019 ◽  
Vol 10 (7) ◽  
pp. 1976-1985 ◽  
Author(s):  
Michael J. Spooner ◽  
Hongyu Li ◽  
Igor Marques ◽  
Pedro M. R. Costa ◽  
Xin Wu ◽  
...  
Keyword(s):  
Lipid Bilayers ◽  
Cell Membranes ◽  
Chloride Transport ◽  
Anion Transporters ◽  
Highly Active ◽  
Active Anion

A series of fluorinated tripodal tris-thioureas function as highly active anion transporters across lipid bilayers and cell membranes.

scholarly journals Chloride Transport Across Planar Lipid Bilayers and Cell Membranes by Steriod-Based Synthetic Anion Transporters

2014 ◽  
Vol 106 (2) ◽  
pp. 188a-189a ◽  
Author(s):  
Hongyu Li ◽  
Germinal Magro ◽  
Luke W. Judd ◽  
Peter R. Brotherhood ◽  
David N. Sheppard ◽  
...  
Keyword(s):  
Lipid Bilayers ◽  
Cell Membranes ◽  
Chloride Transport ◽  
Planar Lipid Bilayers ◽  
Anion Transporters

scholarly journals 1,8-Diamidocarbazoles: an easily tuneable family of fluorescent anion sensors and transporters

2018 ◽  
Vol 16 (28) ◽  
pp. 5188-5196 ◽  
Author(s):  
Krzysztof M. Bąk ◽  
Krzysztof Chabuda ◽  
Helena Montes ◽  
Roberto Quesada ◽  
Michał J. Chmielewski
Keyword(s):  
Fluorescent Sensors ◽  
Turn On ◽  
Anion Transporters ◽  
Highly Active ◽  
Anion Sensors ◽  
Active Anion

Simple and easy to make diamidocarbazoles have been shown to be highly active anion transporters and sensitive turn-ON fluorescent sensors for H2PO4− and AcO−.

scholarly journals Boosting Anion Transport Activity of Diamidocarbazoles by Electron Withdrawing Substituents

2021 ◽  
Vol 9 ◽  
Author(s):  
Krystyna Maslowska-Jarzyna ◽  
Maria L. Korczak ◽  
Michał J. Chmielewski
Keyword(s):  
Lipid Bilayers ◽  
Chloride Transport ◽  
Mechanistic Studies ◽  
Transport Activity ◽  
Present Contribution ◽  
Highly Active ◽  
Large Unilamellar Vesicles ◽  
Carrier Mechanism ◽  
Anion Transport Activity ◽  
Electron Withdrawing Substituents

Artificial chloride transporters have been intensely investigated in view of their potential medicinal applications. Recently, we have established 1,8-diamidocarbazoles as a versatile platform for the development of active chloride carriers. In the present contribution, we investigate the influence of various electron-withdrawing substituents in positions 3 and 6 of the carbazole core on the chloride transport activity of these anionophores. Using lucigenin assay and large unilamellar vesicles as models, the 3,6-dicyano- and 3,6-dinitro- substituted receptors were found to be highly active and perfectly deliverable chloride transporters, with EC50,270s value as low as 22 nM for the Cl−/NO3− exchange. Mechanistic studies revealed that diamidocarbazoles form 1:1 complexes with chloride in lipid bilayers and facilitate chloride/nitrate exchange by carrier mechanism. Furthermore, owing to its increased acidity, the 3,6-dinitro- substituted receptor acts as a pH-switchable transporter, with physiologically relevant apparent pKa of 6.4.

scholarly journals Delivering anion transporters to lipid bilayers in water

2021 ◽  
Author(s):  
Daniel A. McNaughton ◽  
Tsz Ying (Teresa) To ◽  
Bryson A. Hawkins ◽  
David E. Hibbs ◽  
Philip Alan Gale
Keyword(s):  
Organic Solvent ◽  
Lipid Bilayers ◽  
Anion Transporters ◽  
Lipophilic Anion

CYCLODEXTRINS HAVE BEEN EMPLOYED AS DELIVERY AGENTS FOR LIPOPHILIC ANION TRANSPORTERS, WHICH ALLOW THEIR INCORPORATION INTO LIPID BILAYERS WITHOUT USING AN ORGANIC SOLVENT OR PRE-INCORPORATION.

Increasing membrane permeability of carboxylic acid-containing drugs using synthetic transmembrane anion transporters

2021 ◽  
Author(s):  
Rayhanus Salam ◽  
Surid Mohammad Chowdhury ◽  
Sarah Ruth Marshall ◽  
Hassan Gneid ◽  
Nathalie Busschaert
Keyword(s):  
Carboxylic Acid ◽  
Membrane Permeability ◽  
Lipid Bilayers ◽  
Small Molecule ◽  
Anion Transporters

In this manuscript, we show that small-molecule-based anion transporters can significantly increase the permeability of carboxylic acid containing drugs across lipid bilayers of model vesicles. Due to the drug-like characteristics...

scholarly journals Small molecule anion transporters display in vitro antimicrobial activity against clinically relevant bacterial strains

2019 ◽  
Vol 55 (68) ◽  
pp. 10080-10083 ◽  
Author(s):  
Israel Carreira-Barral ◽  
Carlos Rumbo ◽  
Marcin Mielczarek ◽  
Daniel Alonso-Carrillo ◽  
Enara Herran ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Small Molecule ◽  
Bacterial Strains ◽  
Antibiotic Resistant ◽  
In Vitro Antimicrobial Activity ◽  
Anion Transporters ◽  
Highly Active

Highly active transmembrane anion transporters have demonstrated their activity against antibiotic-resistant and clinically relevant bacterial strains.

A Highly Active Anion-Selective Aminocyclodextrin Ion Channel

2005 ◽  
Vol 117 (46) ◽  
pp. 7756-7759 ◽  
Author(s):  
Nandita Madhavan ◽  
Erin C. Robert ◽  
Mary S. Gin
Keyword(s):  
Ion Channel ◽  
Highly Active ◽  
Active Anion
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