Cross-linked small-molecule capsules with excitation wavelength-dependent photoluminescence and high loading capacity: design, synthesis and application in imaging-guided drug delivery

2020 ◽  
Vol 8 (13) ◽  
pp. 2719-2725
Author(s):  
Qian Zhang ◽  
Yun Chen ◽  
Ruilin Lu ◽  
Yongchao Yao ◽  
Chuanqi Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Small Molecule ◽  
High Loading ◽  
Excitation Wavelength ◽  
Loading Capacity ◽  
Capacity Design ◽  
Design Synthesis

Cross-linked small-molecule capsules with excitation wavelength-dependent photoluminescence and high loading capacity: design, synthesis and application in imaging-guided drug delivery.

Metal–organic frameworks: a universal strategy towards super-elastic hydrogels

2019 ◽  
Vol 10 (18) ◽  
pp. 2263-2272 ◽  
Author(s):  
Huaizhi Liu ◽  
Hao Peng ◽  
Yumeng Xin ◽  
Jiuyang Zhang
Keyword(s):  
Drug Delivery ◽  
Mechanical Performance ◽  
Metal Organic Framework ◽  
Metal Organic Frameworks ◽  
High Loading ◽  
Loading Capacity ◽  
Metal Organic ◽  
First Time ◽  
Organic Framework

We reported for the first time using metal–organic framework (MOF) nanoparticles as effective nanofillers to significantly enhance the mechanical performance of hydrogels. The MOF hydrogels have been developed for drug delivery materials with high loading capacity and much extended drug releasing profiles.

Lipoic acid based core cross-linked micelles for multivalent platforms: design, synthesis and application in bio-imaging and drug delivery

2017 ◽  
Vol 15 (22) ◽  
pp. 4798-4802 ◽  
Author(s):  
Jingsheng Huang ◽  
Fang Wu ◽  
Yunlong Yu ◽  
Haolong Huang ◽  
Shiyong Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Small Molecule ◽  
Lipoic Acid ◽  
Design Synthesis ◽  
Bio Imaging

Natural lipoic acid derived small-molecule amphiphiles self-assemble into micelles in water.

scholarly journals Bio-orthogonal triazolinedione (TAD) crosslinked protein nanocapsules affect protein adsorption and cell interaction

2020 ◽  
Vol 11 (23) ◽  
pp. 3821-3830 ◽  
Author(s):  
Marie-Luise Frey ◽  
Johanna Simon ◽  
Maximilian Brückner ◽  
Volker Mailänder ◽  
Svenja Morsbach ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Click Chemistry ◽  
Protein Adsorption ◽  
Drug Delivery Systems ◽  
Cell Interaction ◽  
Delivery Systems ◽  
High Loading ◽  
Loading Capacity ◽  
Low Toxicity

Albumin-based protein nanocarriers obtained by TAD click chemistry have been widely exploited as drug delivery systems, since they show excellent degradability, low toxicity, but at the same time provide high loading capacity and relevant uptake into cells.

ZIF-67@Co-LDH yolk–shell spheres with micro-/meso-porous structures as vehicles for drug delivery

2019 ◽  
Vol 6 (11) ◽  
pp. 3140-3145 ◽  
Author(s):  
Liyong Chen ◽  
Jinfeng Wang ◽  
Xiaoshuang Shen ◽  
Xuezhao Li ◽  
Chunying Duan
Keyword(s):  
Drug Delivery ◽  
High Loading ◽  
Loading Capacity ◽  
Porous Structures ◽  
Delivery Time

The encapsulated R6G molecules in ZIF-67@Co-LDH yolk–shell heterostructures are released with high loading capacity and long delivery time.

Fe3O4@nanogel via UOx/HRP initiated surface polymerization for pH sensitive drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (58) ◽  
pp. 53170-53174 ◽  
Author(s):  
Qing Wu ◽  
Zhaoqi Wang ◽  
Haixia Zhang ◽  
Rongrong Zhu ◽  
Shilong Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Free Radical ◽  
Drug Release ◽  
Radical Polymerization ◽  
High Loading ◽  
Core Shell ◽  
Loading Capacity ◽  
Ph Responsive ◽  
Surface Polymerization ◽  
New Strategy

This study describes a new strategy to fabricate core–shell nanogels by surface free-radical polymerization initiated by the cascade reaction of UOx and HRP, which showed excellent biocompatible, high loading capacity and pH-responsive drug release.

Facile Hydrothermal Fabrication of Eu Doped Alumina for Potential Bioluminescent Imaging and Drug Delivery System

2021 ◽  
Vol 875 ◽  
pp. 359-365
Author(s):  
Numrah Sultan ◽  
Syed Mujtaba Ul Hassan ◽  
Jamil Ahmad ◽  
Ahmat Khurshid ◽  
Zahid Ali ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Loading ◽  
Degree Of Crystallinity ◽  
Excitation Wavelength ◽  
Loading Capacity ◽  
Step Method ◽  
Sem Images ◽  
Prepared Sample ◽  
Theranostic Applications ◽  
The Eu

The aim of this study is to investigate the photoluminescence (PL) properties of europium (Eu) doped alumina as potential platform for simultaneous bio Imaging and drug delivery. Synthesis of Eu doped alumina is done by a facile two step method. In the first stage, hydrothermal synthesis is used to prepare the Eu doped ammonium aluminum carbonate hydroxide which is then calcined to get a crystalline Eu doped alumina. Structural characterization of the prepared sample is done through XRD and SEM. Photoluminescence spectroscopy is performed in order the study the PL response. The SEM images of the Eu doped sample revealed whisker shaped morphology, the porosity in the inter and intra whisker region is beneficial for the high drug loading capacity. The length of the bundle after annealing was about 5 µm with the bundle diameter of 0.45 µm. XRD patterns of the prepared sample has sharp peaks, showing a high degree of crystallinity corresponding to the α-alumina phase. Finally PL response was checked at an excitation wavelength of 393 nm. A dominant peak was observed at a wavelength of 613 nm corresponding to the 5D0 to 7F2 transition.The3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide MTT assay confirms the cell viability of more than 100% at even a concentration of 500 nano molar alumina in phosphate-buffered saline (PBS). These results show that the Eu doped alumina having optimum PL response, high biocompatibility and drug loading capacity which makes it a promising candidate for theranostic applications.

Synthesis of poly(lactide-co-glycerol) as a biodegradable and biocompatible polymer with high loading capacity for dermal drug delivery

Nanoscale ◽  
2018 ◽  
Vol 10 (35) ◽  
pp. 16848-16856 ◽  
Author(s):  
Fatemeh Zabihi ◽  
Patrick Graff ◽  
Fabian Schumacher ◽  
Burkhard Kleuser ◽  
Sarah Hedtrich ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Penetration Enhancers ◽  
High Loading ◽  
Loading Capacity ◽  
Biocompatible Polymer ◽  
Dermal Drug Delivery

Due to the low cutaneous bioavailability of tacrolimus (TAC), penetration enhancers are used to improve its penetration into the skin.

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