scholarly journals Fabrication of functional hollow microspheres constructed from MOF shells: Promising drug delivery systems with high loading capacity and targeted transport

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Xuechuan Gao ◽  
Xiao Hai ◽  
Huricha Baigude ◽  
Weihua Guan ◽  
Zhiliang Liu
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Hollow Microspheres ◽  
High Loading ◽  
Loading Capacity ◽  
Targeted Transport

scholarly journals Bio-orthogonal triazolinedione (TAD) crosslinked protein nanocapsules affect protein adsorption and cell interaction

2020 ◽  
Vol 11 (23) ◽  
pp. 3821-3830 ◽  
Author(s):  
Marie-Luise Frey ◽  
Johanna Simon ◽  
Maximilian Brückner ◽  
Volker Mailänder ◽  
Svenja Morsbach ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Click Chemistry ◽  
Protein Adsorption ◽  
Drug Delivery Systems ◽  
Cell Interaction ◽  
Delivery Systems ◽  
High Loading ◽  
Loading Capacity ◽  
Low Toxicity

Albumin-based protein nanocarriers obtained by TAD click chemistry have been widely exploited as drug delivery systems, since they show excellent degradability, low toxicity, but at the same time provide high loading capacity and relevant uptake into cells.

scholarly journals Development of polycationic amphiphilic cyclodextrin nanoparticles for anticancer drug delivery

2017 ◽  
Vol 8 ◽  
pp. 1457-1468 ◽  
Author(s):  
Gamze Varan ◽  
Juan M Benito ◽  
Carmen Ortiz Mellet ◽  
Erem Bilensoy
Keyword(s):  
Drug Delivery ◽  
Cell Line ◽  
Anticancer Drug ◽  
Drug Delivery Systems ◽  
Drug Carrier ◽  
Delivery Systems ◽  
Loading Capacity ◽  
Promising Alternative ◽  
Cytotoxicity Studies ◽  
Amphiphilic Cyclodextrin

Background: Paclitaxel is a potent anticancer drug that is effective against a wide spectrum of cancers. To overcome its bioavailability problems arising from very poor aqueous solubility and tendency to recrystallize upon dilution, paclitaxel is commercially formulated with co-solvents such as Cremophor EL® that are known to cause serious side effects during chemotherapy. Amphiphilic cyclodextrins are favored oligosaccharides as drug delivery systems for anticancer drugs, having the ability to spontaneously form nanoparticles without surfactant or co-solvents. In the past few years, polycationic, amphiphilic cyclodextrins were introduced as effective agents for gene delivery in the form of nanoplexes. In this study, the potential of polycationic, amphiphilic cyclodextrin nanoparticles were evaluated in comparison to non-ionic amphiphilic cyclodextrins and core–shell type cyclodextrin nanoparticles for paclitaxel delivery to breast tumors. Pre-formulation studies were used as a basis for selecting the suitable organic solvent and surfactant concentration for the novel polycationic cyclodextrin nanoparticles. The nanoparticles were then extensively characterized with particle size distribution, polydispersity index, zeta potential, drug loading capacity, in vitro release profiles and cytotoxicity studies. Results: Paclitaxel-loaded cyclodextrin nanoparticles were obtained in the diameter range of 80−125 nm (depending on the nature of the cyclodextrin derivative) where the smallest diameter nanoparticles were obtained with polycationic (PC) βCDC6. A strong positive charge also helped to increase the loading capacity of the nanoparticles with paclitaxel up to 60%. Interestingly, cyclodextrin nanoparticles were able to stabilize paclitaxel in aqueous solution for 30 days. All blank cyclodextrin nanoparticles were demonstrated to be non-cytotoxic against L929 mouse fibroblast cell line. In addition, paclitaxel-loaded nanoparticles have a significant anticancer effect against MCF-7 human breast cancer cell line as compared with a paclitaxel solution in DMSO. Conclusion: According to the results of this study, both amphiphilic cyclodextrin derivatives provide suitable nanometer-sized drug delivery systems for safe and efficient intravenous paclitaxel delivery for chemotherapy. In the light of these studies, it can be said that amphiphilic cyclodextrin nanoparticles of different surface charge can be considered as a promising alternative for self-assembled nanometer-sized drug carrier systems for safe and efficient chemotherapy.

A REVIEW ON THE SECOND-GENERATION LIPID CARRIERS: NLC’S

2021 ◽  
Vol 12 (4) ◽  
pp. 176-182
Author(s):  
A N Jyothsna Sree
Keyword(s):  
Drug Delivery ◽  
Solid Lipid Nanoparticles ◽  
Drug Delivery Systems ◽  
Drug Loading ◽  
Lipid Nanoparticles ◽  
Delivery Systems ◽  
Nanostructured Lipid Carriers ◽  
Loading Capacity ◽  
The Past ◽  
Key Aspects

Over the past few years, nanostructured lipid carriers became an emerging drug delivery system as lipid drug delivery systems are more focused. Within them, solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) have more advantages over other lipid carriers. This article is a cumulation of structure, types, composition, formulation methodologies, drug release from NLCs, various applications of NLCs. The key aspects for promising drug delivery systems are biocompatibility, drug loading capacity, ease of preparation, non-toxicity, and stability

scholarly journals Developments of Smart Drug-Delivery Systems Based on Magnetic Molecularly Imprinted Polymers for Targeted Cancer Therapy: A Short Review

Pharmaceutics ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 831
Author(s):  
Nasim Sanadgol ◽  
Judith Wackerlig
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Molecularly Imprinted Polymers ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Loading Capacity ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Smart Drug ◽  
Smart Drug Delivery

Cancer therapy is still a huge challenge, as especially chemotherapy shows several drawbacks like low specificity to tumor cells, rapid elimination of drugs, high toxicity and lack of aqueous solubility. The combination of molecular imprinting technology with magnetic nanoparticles provides a new class of smart hybrids, i.e., magnetic molecularly imprinted polymers (MMIPs) to overcome limitations in current cancer therapy. The application of these complexes is gaining more interest in therapy, due to their favorable properties, namely, the ability to be guided and to generate slight hyperthermia with an appropriate external magnetic field, alongside the high selectivity and loading capacity of imprinted polymers toward a template molecule. In cancer therapy, using the MMIPs as smart-drug-delivery robots can be a promising alternative to conventional direct administered chemotherapy, aiming to enhance drug accumulation/penetration into the tumors while fewer side effects on the other organs. Overview: In this review, we state the necessity of further studies to translate the anticancer drug-delivery systems into clinical applications with high efficiency. This work relates to the latest state of MMIPs as smart-drug-delivery systems aiming to be used in chemotherapy. The application of computational modeling toward selecting the optimum imprinting interaction partners is stated. The preparation methods employed in these works are summarized and their attainment in drug-loading capacity, release behavior and cytotoxicity toward cancer cells in the manner of in vitro and in vivo studies are stated. As an essential issue toward the development of a body-friendly system, the biocompatibility and toxicity of the developed drug-delivery systems are discussed. We conclude with the promising perspectives in this emerging field. Areas covered: Last ten years of publications (till June 2020) in magnetic molecularly imprinted polymeric nanoparticles for application as smart-drug-delivery systems in chemotherapy.

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

1985 ◽  
Vol 43 ◽  
pp. 710-711
Author(s):  
G.E. Visscher ◽  
R. L. Robison ◽  
G. J. Argentieri
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Gastrocnemius Muscle ◽  
Degradation Process ◽  
Delivery Systems ◽  
Tissue Reaction ◽  
Electron Microscopic ◽  
Tissue Samples ◽  
Injectable Polymer ◽  
Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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