Multifunctional Mesoporous ZnO@BMMs with Strong Fluorescence and High Loading Capacity for Controlled Drug Delivery

2019 ◽  
Vol 2019 (27) ◽  
pp. 3187-3193
Author(s):  
Junfang Li ◽  
Jihong Sun ◽  
Shiyang Bai ◽  
Xia Wu ◽  
Rensheng Xue
Keyword(s):  
Drug Delivery ◽  
Controlled Drug Delivery ◽  
High Loading ◽  
Loading Capacity ◽  
Strong Fluorescence ◽  
Mesoporous Zno

Metal–organic frameworks: a universal strategy towards super-elastic hydrogels

2019 ◽  
Vol 10 (18) ◽  
pp. 2263-2272 ◽  
Author(s):  
Huaizhi Liu ◽  
Hao Peng ◽  
Yumeng Xin ◽  
Jiuyang Zhang
Keyword(s):  
Drug Delivery ◽  
Mechanical Performance ◽  
Metal Organic Framework ◽  
Metal Organic Frameworks ◽  
High Loading ◽  
Loading Capacity ◽  
Metal Organic ◽  
First Time ◽  
Organic Framework

We reported for the first time using metal–organic framework (MOF) nanoparticles as effective nanofillers to significantly enhance the mechanical performance of hydrogels. The MOF hydrogels have been developed for drug delivery materials with high loading capacity and much extended drug releasing profiles.

scholarly journals Bio-orthogonal triazolinedione (TAD) crosslinked protein nanocapsules affect protein adsorption and cell interaction

2020 ◽  
Vol 11 (23) ◽  
pp. 3821-3830 ◽  
Author(s):  
Marie-Luise Frey ◽  
Johanna Simon ◽  
Maximilian Brückner ◽  
Volker Mailänder ◽  
Svenja Morsbach ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Click Chemistry ◽  
Protein Adsorption ◽  
Drug Delivery Systems ◽  
Cell Interaction ◽  
Delivery Systems ◽  
High Loading ◽  
Loading Capacity ◽  
Low Toxicity

Albumin-based protein nanocarriers obtained by TAD click chemistry have been widely exploited as drug delivery systems, since they show excellent degradability, low toxicity, but at the same time provide high loading capacity and relevant uptake into cells.

ZIF-67@Co-LDH yolk–shell spheres with micro-/meso-porous structures as vehicles for drug delivery

2019 ◽  
Vol 6 (11) ◽  
pp. 3140-3145 ◽  
Author(s):  
Liyong Chen ◽  
Jinfeng Wang ◽  
Xiaoshuang Shen ◽  
Xuezhao Li ◽  
Chunying Duan
Keyword(s):  
Drug Delivery ◽  
High Loading ◽  
Loading Capacity ◽  
Porous Structures ◽  
Delivery Time

The encapsulated R6G molecules in ZIF-67@Co-LDH yolk–shell heterostructures are released with high loading capacity and long delivery time.

Fe3O4@nanogel via UOx/HRP initiated surface polymerization for pH sensitive drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (58) ◽  
pp. 53170-53174 ◽  
Author(s):  
Qing Wu ◽  
Zhaoqi Wang ◽  
Haixia Zhang ◽  
Rongrong Zhu ◽  
Shilong Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Free Radical ◽  
Drug Release ◽  
Radical Polymerization ◽  
High Loading ◽  
Core Shell ◽  
Loading Capacity ◽  
Ph Responsive ◽  
Surface Polymerization ◽  
New Strategy

This study describes a new strategy to fabricate core–shell nanogels by surface free-radical polymerization initiated by the cascade reaction of UOx and HRP, which showed excellent biocompatible, high loading capacity and pH-responsive drug release.

Formulation and Evaluation of Polymeric Nanomicelles of Gliptin for Controlled Drug Delivery

2019 ◽  
Vol 9 (2) ◽  
pp. 146-156 ◽  
Author(s):  
Deepika Sharma ◽  
Bhavna Kumar
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Drug Release ◽  
Zeta Potential ◽  
Polymer Concentration ◽  
Controlled Drug Delivery ◽  
Entrapment Efficiency ◽  
Loading Capacity ◽  
Dissolution Method ◽  
Direct Dissolution

Objective: The main objective of the study was to develop gliptin loaded polymeric nanomicelles by direct dissolution method. The comparative evaluation studies were performed to study the effect of polymer concentration on particle size, entrapment efficiency, loading capacity and drug release of the formulation. Methods: Gliptin loaded polymeric nanomicelles were prepared by the direct dissolution method. The formulations were prepared by varying the concentration of polymer and drug concentration was kept constant in all the formulations. The concentration of polymer (pullulan) was maintained 0.1%, 0.5% 1% in formulation F-1, F-2 and F-3, respectively. The effect of polymer concentration on mean particle size, zeta potential, % entrapment efficiency, % loading capacity and in vitro drug release was studied. Results: The optimized nanoformulation was obtained with pullulan 0.1% concentration with a mean particle diameter of 368.2nm and zeta potential value (-7.96mV) indicating greater stability. Conclusion: Hence F-1 was considered to be the best formulation for the preparation of gliptin loaded polymeric nanomicelles. Hence, it can be concluded that polymeric nanomicellar approach can be beneficial to improve the bioavailability and poor permeability of class III drugs like gliptins and thus can be a better approach for controlled drug delivery.

Synthesis of poly(lactide-co-glycerol) as a biodegradable and biocompatible polymer with high loading capacity for dermal drug delivery

Nanoscale ◽  
2018 ◽  
Vol 10 (35) ◽  
pp. 16848-16856 ◽  
Author(s):  
Fatemeh Zabihi ◽  
Patrick Graff ◽  
Fabian Schumacher ◽  
Burkhard Kleuser ◽  
Sarah Hedtrich ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Penetration Enhancers ◽  
High Loading ◽  
Loading Capacity ◽  
Biocompatible Polymer ◽  
Dermal Drug Delivery

Due to the low cutaneous bioavailability of tacrolimus (TAC), penetration enhancers are used to improve its penetration into the skin.

scholarly journals pH and Thermal Dual-Responsive Nanoparticles for Controlled Drug Delivery with High Loading Content

ACS Omega ◽  
2017 ◽  
Vol 2 (7) ◽  
pp. 3399-3405 ◽  
Author(s):  
Yang Zheng ◽  
Lei Wang ◽  
Lin Lu ◽  
Qian Wang ◽  
Brian C. Benicewicz
Keyword(s):  
Drug Delivery ◽  
Controlled Drug Delivery ◽  
High Loading ◽  
Dual Responsive
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