Synthesis of water-dispersible silicon-containing hydroxyapatite nanoparticles with adjustable degradation rates and their applications as pH-responsive drug carriers

RSC Advances ◽  
2016 ◽  
Vol 6 (115) ◽  
pp. 114852-114858 ◽  
Author(s):  
Kaili Lin ◽  
Na Zhang ◽  
Zhilan Yin ◽  
Yuhui Shen ◽  
Weibin Zhang
Keyword(s):  
Drug Release ◽  
Anticancer Drugs ◽  
Environmentally Friendly ◽  
Drug Carriers ◽  
Hydroxyapatite Nanoparticles ◽  
Ph Responsive ◽  
Water Dispersible ◽  
Degradation Rates ◽  
Ph Dependent ◽  
Environmentally Friendly Method

An environmentally friendly method was developed to synthesize water-dispersible Si-HAp nanoparticles with adjustable degradation rates, high loading capacities for anticancer drugs, and sustained and pH-dependent drug release properties.

scholarly journals Targeted, Monitored, and Controlled Chemotherapy: A Multimodal Nanotechnology-Based Approach against Cancer

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Ali Shakeri-Zadeh ◽  
Samideh Khoei ◽  
Sepideh Khoee ◽  
Ali Mohammad Sharifi ◽  
Mohammad-Bagher Shiran
Keyword(s):  
Drug Release ◽  
Anticancer Drugs ◽  
Polymeric Nanoparticles ◽  
Control Release ◽  
Controlled Drug Release ◽  
Drug Carriers ◽  
Chemotherapeutic Agents ◽  
Drug Uptake ◽  
Cancerous Cell ◽  
Cancer Tumor

We review innovative methods for treatment of cancer tumor on the basis of nanotechnology and physics to target, monitor and control release of chemotherapeutic agents. Chemotherapy is one of the main methods of treatment for cancer and plays a vital role in clinical practice, but side effects of anticancer drugs are still critical problems. Magnetic nanoparticles can be applied as an effective drug carriers and contrast agents for magnetic resonance imaging (MRI). Since certain nanoparticles have magnetic properties, they can be trapped in tumor during blood circulation by an external magnetic field. Also, polymeric nanoparticles are great candidates to encapsulate anticancer drugs and to control the release profile of drugs in biologic media. We suggest the construction of drug-loaded polymer-coated magnetic (DPM) nanoplatform with the potential for being utilized in medical imaging as well as having controlled drug release properties. Nanoplatform distribution can be monitored by MRI and with clever combination of ultrasound physics and suggested DPM nanoplatform, it would be feasible to increase the rate of drug release (in situ) and drug uptake by cancerous cell. To optimize the level of drug uptake by cancerous cell, the selection of ultrasound frequency and intensity is essential. The development of suggested method could be a new approach against cancer tumor.

Cellular uptake of pH/reduction responsive phosphorylcholine micelles

2017 ◽  
Vol 41 (20) ◽  
pp. 11828-11838 ◽  
Author(s):  
Yuanyuan Cai ◽  
Shuai Li ◽  
Mengtan Cai ◽  
Yuanwei Chen ◽  
Xianglin Luo
Keyword(s):  
Drug Release ◽  
Cellular Uptake ◽  
Drug Carriers ◽  
Ph Responsive ◽  
Ph Reduction ◽  
The Relationship

We study the relationship between the PDEA content and internalization/intracellular drug release of pH responsive phosphorylcholine micelles as drug carriers.

Acetalated-dextran as valves of mesoporous silica particles for pH responsive intracellular drug delivery

RSC Advances ◽  
2015 ◽  
Vol 5 (13) ◽  
pp. 9546-9555 ◽  
Author(s):  
Zhe Lin ◽  
Jizhen Li ◽  
Hongyan He ◽  
Huihui Kuang ◽  
Xuesi Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Anticancer Drugs ◽  
Silica Particles ◽  
Ph Sensitive ◽  
Ph Responsive ◽  
Release System ◽  
Intracellular Drug Delivery ◽  
Intracellular Release

A pH-sensitive drug release system using acetalated-dextran as valves was designed to manipulate smart intracellular release of anticancer drugs.

Synergistic dual-pH responsive copolymer micelles for pH-dependent drug release

Nanoscale ◽  
2016 ◽  
Vol 8 (3) ◽  
pp. 1437-1450 ◽  
Author(s):  
Hongzhang Deng ◽  
Xuefei Zhao ◽  
Jinjian Liu ◽  
Jianhua Zhang ◽  
Liandong Deng ◽  
...  
Keyword(s):  
Drug Release ◽  
High Stability ◽  
Degradation Rate ◽  
Ph Responsive ◽  
Physiological Conditions ◽  
Ph Dependent ◽  
Copolymer Micelles ◽  
Acidic Degradation

Doxorubicin encapsulated into micelles of dual-pH responsive copolymer show fast acidic-degradation rate but high stability under physiological conditions.

scholarly journals Schiff-Linked PEGylated Doxorubicin Prodrug Forming pH-Responsive Nanoparticles With High Drug Loading and Effective Anticancer Therapy

2021 ◽  
Vol 11 ◽  
Author(s):  
Jian Song ◽  
Bingbing Xu ◽  
Hui Yao ◽  
Xiaofang Lu ◽  
Yang Tan ◽  
...  
Keyword(s):  
Drug Release ◽  
Tumor Cells ◽  
Drug Loading ◽  
Drug Carriers ◽  
Anticancer Therapy ◽  
Therapeutic Effects ◽  
Ph Responsive ◽  
High Drug ◽  
High Drug Loading ◽  
Mcf 7

Developing efficacious drug delivery systems for targeted cancer chemotherapy remains a major challenge. Here we demonstrated a kind of pH-responsive PEGylated doxorubicin (DOX) prodrug via the effective esterification and Schiff base reactions, which could self-assemble into the biodegradable micelles in aqueous solutions. Owing to low pH values inside the tumor cells, these PEG-Schiff-DOX nanoparticles exhibited high drug loading ability and pH-responsive drug release behavior within the tumor cells or tissues upon changes in physical and chemical environments, but they displayed good stability at physiological conditions for a long period. CCK-8 assay showed that these PEGylated DOX prodrugs had a similar cytotoxicity to the MCF-7 tumor cells as the free DOX drug. Moreover, this kind of nanoparticle could also encapsulate small DOX drugs with high drug loading, sufficient drug release and enhanced therapeutic effects toward MCF-7 cells, which will be benefited for developing more drug carriers with desirable functions for clinical anticancer therapy.

scholarly journals Design of silk–vaterite microsphere systems as drug carriers with pH-responsive release behavior

2015 ◽  
Vol 3 (42) ◽  
pp. 8314-8320 ◽  
Author(s):  
S. S. Liu ◽  
L. J. Liu ◽  
L. Y. Xiao ◽  
Q. Lu ◽  
H. S. Zhu ◽  
...  
Keyword(s):  
Thermal Treatment ◽  
Drug Release ◽  
Drug Carriers ◽  
Treatment Method ◽  
Release Behavior ◽  
Ph Responsive ◽  
The Stability

A simple thermal treatment method was developed to control the stability of silk–vaterite microspheres and achieve tunable drug release behaviors.

pH-Responsive expandable polycarbonate-doxorubicin conjugate nanoparticles for fast intracellular drug release

2021 ◽  
Author(s):  
Enhui Liang ◽  
Zhihao Guo ◽  
Zhuang Hu ◽  
Zhang-Pei Chen ◽  
Aikebaier Reheman ◽  
...  
Keyword(s):  
Drug Release ◽  
Drug Carriers ◽  
Circulation Time ◽  
Powerful Method ◽  
Ph Responsive ◽  
Anticancer Treatment ◽  
Drug Leakage ◽  
Early Drug

Nanoparticles used as drug carriers with prolonged circulation time, reduced early drug leakage, stimulus triggered and improved drug release is a powerful method for anticancer treatment. Herein, a new tailor-made...

Nanostructures for pH-sensitive Drug Delivery and Magnetic Resonance Contrast Enhancement Systems

2018 ◽  
Vol 25 (25) ◽  
pp. 3036-3057 ◽  
Author(s):  
Xiao Sun ◽  
Guilong Zhang ◽  
Zhengyan Wu
Keyword(s):  
Drug Delivery ◽  
Magnetic Resonance ◽  
Drug Release ◽  
Contrast Enhancement ◽  
General Strategy ◽  
Ph Responsive ◽  
Physicochemical Changes ◽  
Magnetic Resonance Contrast ◽  
Resonance Contrast ◽  
Magnetic Resonance Contrast Enhancement

According to the differences of microenvironments between tumors and healthy tissues, if the anticancer drugs or magnetic resonance contrast agents (MRCAs) can be controlled to precisely match physiological needs at targeted tumor sites, it is expected to acquire better therapeutic efficacy and more accurate diagnosis. Over the decade, stimuli-responsive nanomaterials have been a research hotspot for cancer treatment and diagnosis because they show many excellent functions, such as in vivo imaging, combined targeting drug delivery and systemic controlled release, extended circulation time, etc. Among the various stimuli nanosystems, pH-stimuli mode is regarded as the most general strategy because of solid tumors acidosis. When exposed to weakly acidic tumor microenvironment, pH-responsive nanoplatforms can generate physicochemical changes for their structure and surface characteristics, causing drug release or contrast enhancement. In this review, we focused on the designs of various pH-responsive nanoplatforms and discussed the mechanisms of controlled drug release or switch on-off in MRCAs. This review also discussed the efficacy of cellular internalization for these nanoplatforms via endocytosis of acidic tumor cell. Meanwhile, nanoplatforms response to acidic intracellular pH (such as endosome, lysosome) are discussed, along with approaches for improving drug release performance and magnetic resonance contrast enhancement. A greater understanding of these pH-responsive nanoplatforms will help design more efficient nanomedicine to address the challenges encountered in conventional diagnosis and chemotherapy.

scholarly journals Self-Assembling pH-Responsive Nanoparticle Platform Based on Pectin–Doxorubicin Conjugates for Codelivery of Anticancer Drugs

ACS Omega ◽  
2021 ◽  
Author(s):  
Yinghua Tao ◽  
Dan Zheng ◽  
Jingyang Zhao ◽  
Kefeng Liu ◽  
Jing Liu ◽  
...  
Keyword(s):  
Anticancer Drugs ◽  
Ph Responsive ◽  
Self Assembling

scholarly journals pH-responsive antibodies for therapeutic applications

2021 ◽  
Vol 28 (1) ◽  
Author(s):  
Tomasz Klaus ◽  
Sameer Deshmukh
Keyword(s):  
Drug Delivery ◽  
Treatment Outcome ◽  
Tumor Microenvironment ◽  
Dependent Manner ◽  
Therapeutic Antibodies ◽  
Ph Responsive ◽  
Biologic Drugs ◽  
Car T ◽  
Ph Dependent ◽  
The Brain

AbstractTherapeutic antibodies are instrumental in improving the treatment outcome for certain disease conditions. However, to enhance their efficacy and specificity, many efforts are continuously made. One of the approaches that are increasingly explored in this field are pH-responsive antibodies capable of binding target antigens in a pH-dependent manner. We reviewed suitability and examples of these antibodies that are functionally modulated by the tumor microenvironment. Provided in this review is an update about antigens targeted by pH-responsive, sweeping, and recycling antibodies. Applicability of the pH-responsive antibodies in the engineering of chimeric antigen receptor T-cells (CAR-T) and in improving drug delivery to the brain by the enhanced crossing of the blood–brain barrier is also discussed. The pH-responsive antibodies possess strong treatment potential. They emerge as next-generation programmable engineered biologic drugs that are active only within the targeted biological space. Thus, they are valuable in targeting acidified tumor microenvironment because of improved spatial persistence and reduced on-target off-tumor toxicities. We predict that the programmable pH-dependent antibodies become powerful tools in therapies of cancer.

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