scholarly journals Design of silk–vaterite microsphere systems as drug carriers with pH-responsive release behavior

2015 ◽  
Vol 3 (42) ◽  
pp. 8314-8320 ◽  
Author(s):  
S. S. Liu ◽  
L. J. Liu ◽  
L. Y. Xiao ◽  
Q. Lu ◽  
H. S. Zhu ◽  
...  
Keyword(s):  
Thermal Treatment ◽  
Drug Release ◽  
Drug Carriers ◽  
Treatment Method ◽  
Release Behavior ◽  
Ph Responsive ◽  
The Stability

A simple thermal treatment method was developed to control the stability of silk–vaterite microspheres and achieve tunable drug release behaviors.

scholarly journals Heat Treatment Induced Specified Aggregation Morphology of Metoprolol Tartrate in Poly(ε-caprolactone) Matrix and the Drug Release Variation

Polymers ◽  
2021 ◽  
Vol 13 (18) ◽  
pp. 3076
Author(s):  
Zhiyu Liu ◽  
Hangling Song ◽  
Xia Chen ◽  
Aichun Han ◽  
Guiting Liu ◽  
...  
Keyword(s):  
Heat Treatment ◽  
Drug Release ◽  
Controlled Drug Release ◽  
Treatment Method ◽  
Melt Processing ◽  
Metoprolol Tartrate ◽  
Release Behavior ◽  
Drug Release Behavior ◽  
Phosphate Buffered Saline ◽  
Hot Melt

Hot-melt blending has been widely used in the pharmaceutical industry to produce drug delivery systems, however, realizing the controlled drug release behavior of a hot-melt blended medicament it is still a tough challenge. In this study, we developed a simple and effective heat treatment method to adjust the drug release behavior, without the addition of any release modifiers. Thin metoprolol tartrate (MPT)/poly(ε-caprolactone) (PCL) tablets were prepared through hot-melt processing, and different morphologies of MPT were obtained by altering processing temperatures and the following heat treatment. MPT particles with different particle sizes were obtained under different processing temperatures, and fibrous crystals of MPT were fabricated during the following heat treatment. Different morphological structures of MPT adjusted the drug diffusion channel when immersed in phosphate-buffered saline (PBS), and various drug release behaviors were approached. After being immersed for 24 h, 7% of the MPT was released from the blend processed at 130 °C, while more than 95% of the MPT were released after the following heat treatment of the same sample. Thus, flexible drug release behaviors were achieved using this simple and effective processing manufacture, which is demonstrated to be of profound importance for biomedical applications.

scholarly journals ENZYMATICALLY SYNTHESIZED pH-RESPONSIVE IPN FOR IN-SITU RELEASE OF PANTOPRAZOLE SODIUM

2019 ◽  
pp. 98-103
Author(s):  
Saruchi Sharma ◽  
VANEET KUMAR
Keyword(s):  
Drug Release ◽  
Polymer Network ◽  
Lateral Diffusion ◽  
Ph Sensitive ◽  
Interpenetrating Polymer Network ◽  
Release Behavior ◽  
Ph Responsive ◽  
Gum Tragacanth ◽  
Swelling Capacity

Objective: This study involves the synthesis of Gum tragacanth (gt) based interpenetrating polymer network (ipn) and its utilization for sustained release of anti-ulcerative drug i.e. pantoprazole sodium. Methods: IPN was synthesized from Gum tragacanth, polyacrylic acid (gt-cl-paa) hydrogel. gt-cl-paa was kept in distilled water. Further, acryamide (aam) and methylmethacrylate (mma) was added and then kept for overnight. Later on, lipase and glutaraldehyde were added. Homopolymers and the unreacted monomers were removed using acetone. Synthesized IPN was dried at 50 °C for further study. Synthesized ipn was swelled in water and the drug was added to it. The drug was entrapped in the pores of the synthesized ipn and then drug release behavior was studied using uv-vis spectrophotometer. Results: Gt, paa and mma based crosslinked IPN were synthesized using lipase-glutaraldehyde as initiator-crosslinker system. The synthesized IPN was pH sensitive and possessed the desired swelling capacity required for the controlled and systematic liberation of pantoprazole sodium at 37 °C. The kinetic of drug release was studied and found that lateral diffusion (DL) of drug was higher as compared to the initial diffusion (DI). The prepared IPN can be used as prospective carrier for prolonged drug delivery. Conclusion: A novel pH sensitive and colon targeted IPN was synthesized. It acts as an effective device for the controlled release of drug pantoprazole sodium.

Cellular uptake of pH/reduction responsive phosphorylcholine micelles

2017 ◽  
Vol 41 (20) ◽  
pp. 11828-11838 ◽  
Author(s):  
Yuanyuan Cai ◽  
Shuai Li ◽  
Mengtan Cai ◽  
Yuanwei Chen ◽  
Xianglin Luo
Keyword(s):  
Drug Release ◽  
Cellular Uptake ◽  
Drug Carriers ◽  
Ph Responsive ◽  
Ph Reduction ◽  
The Relationship

We study the relationship between the PDEA content and internalization/intracellular drug release of pH responsive phosphorylcholine micelles as drug carriers.

scholarly journals Controlled release evaluation of paracetamol loaded amine functionalized mesoporous silica KCC1 compared to microcrystalline cellulose based tablets

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Marieh Pishnamazi ◽  
Hamid Hafizi ◽  
Mahboubeh Pishnamazi ◽  
Azam Marjani ◽  
Saeed Shirazian ◽  
...  
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Microcrystalline Cellulose ◽  
Release Rate ◽  
Drug Carriers ◽  
Release Behavior ◽  
Drug Controlled Release ◽  
Remarkable Effect ◽  
Functionalized Mesoporous Silica

AbstractIn the pharmaceutical manufacturing, drug release behavior development is remained as one of the main challenges to improve the drug effectiveness. Recently, more focus has been done on using mesoporous silica materials as drug carriers for prolonged and superior control of drug release in human body. In this study, release behavior of paracetamol is developed using drug-loaded KCC-1-NH2 mesoporous silica, based on direct compaction method for preparation of tablets. The purpose of this study is to investigate the utilizing of pure KCC-1 mesoporous silica (KCC-1) and amino functionalized KCC-1 (KCC-1-NH2) as drug carriers in oral solid dosage formulations compared to common excipient, microcrystalline cellulose (MCC), to improve the control of drug release rate by manipulating surface chemistry of the carrier. Different formulations of KCC-1 and KCC-NH2 are designed to investigate the effect of functionalized mesoporous silica as carrier on drug controlled-release rate. The results displayed the remarkable effect of KCC-1-NH2 on drug controlled-release in comparison with the formulation containing pure KCC-1 and formulation including MCC as reference materials. The pure KCC-1 and KCC-1-NH2 are characterized using different evaluation methods such as FTIR, SEM, TEM and N2 adsorption analysis.

Control of drug release behavior of pH-responsive PVA/PAAc hydrogel by surface modification with oxyfluorination

2012 ◽  
Vol 20 (10) ◽  
pp. 1029-1036 ◽  
Author(s):  
Jumi Yun ◽  
Ae-Ri Oh ◽  
Ji Sun Im ◽  
Hyung-Il Kim ◽  
Young-Seak Lee
Keyword(s):  
Surface Modification ◽  
Drug Release ◽  
Release Behavior ◽  
Ph Responsive ◽  
Drug Release Behavior

Synthesis of water-dispersible silicon-containing hydroxyapatite nanoparticles with adjustable degradation rates and their applications as pH-responsive drug carriers

RSC Advances ◽  
2016 ◽  
Vol 6 (115) ◽  
pp. 114852-114858 ◽  
Author(s):  
Kaili Lin ◽  
Na Zhang ◽  
Zhilan Yin ◽  
Yuhui Shen ◽  
Weibin Zhang
Keyword(s):  
Drug Release ◽  
Anticancer Drugs ◽  
Environmentally Friendly ◽  
Drug Carriers ◽  
Hydroxyapatite Nanoparticles ◽  
Ph Responsive ◽  
Water Dispersible ◽  
Degradation Rates ◽  
Ph Dependent ◽  
Environmentally Friendly Method

An environmentally friendly method was developed to synthesize water-dispersible Si-HAp nanoparticles with adjustable degradation rates, high loading capacities for anticancer drugs, and sustained and pH-dependent drug release properties.

Host–Guest Assembly of pH-Responsive Degradable Microcapsules with Controlled Drug Release Behavior

2011 ◽  
Vol 115 (36) ◽  
pp. 17651-17659 ◽  
Author(s):  
Cao Li ◽  
Guo-Feng Luo ◽  
Hui-Yuan Wang ◽  
Jing Zhang ◽  
Yu-Hui Gong ◽  
...  
Keyword(s):  
Drug Release ◽  
Controlled Drug Release ◽  
Release Behavior ◽  
Ph Responsive ◽  
Drug Release Behavior

scholarly journals Schiff-Linked PEGylated Doxorubicin Prodrug Forming pH-Responsive Nanoparticles With High Drug Loading and Effective Anticancer Therapy

2021 ◽  
Vol 11 ◽  
Author(s):  
Jian Song ◽  
Bingbing Xu ◽  
Hui Yao ◽  
Xiaofang Lu ◽  
Yang Tan ◽  
...  
Keyword(s):  
Drug Release ◽  
Tumor Cells ◽  
Drug Loading ◽  
Drug Carriers ◽  
Anticancer Therapy ◽  
Therapeutic Effects ◽  
Ph Responsive ◽  
High Drug ◽  
High Drug Loading ◽  
Mcf 7

Developing efficacious drug delivery systems for targeted cancer chemotherapy remains a major challenge. Here we demonstrated a kind of pH-responsive PEGylated doxorubicin (DOX) prodrug via the effective esterification and Schiff base reactions, which could self-assemble into the biodegradable micelles in aqueous solutions. Owing to low pH values inside the tumor cells, these PEG-Schiff-DOX nanoparticles exhibited high drug loading ability and pH-responsive drug release behavior within the tumor cells or tissues upon changes in physical and chemical environments, but they displayed good stability at physiological conditions for a long period. CCK-8 assay showed that these PEGylated DOX prodrugs had a similar cytotoxicity to the MCF-7 tumor cells as the free DOX drug. Moreover, this kind of nanoparticle could also encapsulate small DOX drugs with high drug loading, sufficient drug release and enhanced therapeutic effects toward MCF-7 cells, which will be benefited for developing more drug carriers with desirable functions for clinical anticancer therapy.

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