Acetalated-dextran as valves of mesoporous silica particles for pH responsive intracellular drug delivery

RSC Advances ◽  
2015 ◽  
Vol 5 (13) ◽  
pp. 9546-9555 ◽  
Author(s):  
Zhe Lin ◽  
Jizhen Li ◽  
Hongyan He ◽  
Huihui Kuang ◽  
Xuesi Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Anticancer Drugs ◽  
Silica Particles ◽  
Ph Sensitive ◽  
Ph Responsive ◽  
Release System ◽  
Intracellular Drug Delivery ◽  
Intracellular Release

A pH-sensitive drug release system using acetalated-dextran as valves was designed to manipulate smart intracellular release of anticancer drugs.

scholarly journals One-pot synthesis of biodegradable polydopamine-doped mesoporous silica nanocomposites (PMSNs) as pH-sensitive targeting drug nanocarriers for synergistic chemo-photothermal therapy

RSC Advances ◽  
2018 ◽  
Vol 8 (65) ◽  
pp. 37433-37440 ◽  
Author(s):  
Huicong Zhang ◽  
Xuandong Wang ◽  
Peiyuan Wang ◽  
Rong Liu ◽  
Xuemei Hou ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Photothermal Therapy ◽  
Ph Sensitive ◽  
Ph Responsive ◽  
One Pot ◽  
Silica Nanocomposites ◽  
One Pot Synthesis ◽  
Drug Nanocarriers

Polydopamine-doped mesoporous silica nanocomposites (PMSNs) were controllably synthesized by a one-pot approach. They were demonstrated to be good biodegradability, pH-responsive drug release and targeting synergistic chemo-photothermal therapy.

Lipid Nanocapsules for Intracellular Drug Delivery of Anticancer Drugs

2007 ◽  
Vol 7 (12) ◽  
pp. 4612-4617 ◽  
Author(s):  
Franck Lacoeuille ◽  
Emmanuel Garcion ◽  
Jean-Pierre Benoit ◽  
Alf Lamprecht
Keyword(s):  
Drug Delivery ◽  
Cell Culture ◽  
Drug Release ◽  
Anticancer Drugs ◽  
Cancer Cell ◽  
Release Kinetics ◽  
Laser Scanning Microscopy ◽  
Lipid Nanocapsules ◽  
Intracellular Drug Delivery ◽  
Drug Concentrations

As non-phagocytic eukaryotic cells can internalize particles <1 μm in size, small size (25 to 110 nm) lipid nanocapsules (LNC) are proposed for the intracellular drug delivery of anticancer drugs to cancer cells. LNC ofdifferent diameters were loaded with etoposide or paclitaxel and subsequently tested for drug release kinetics and their efficiency to reduce cancer cell growth in cell culture. Relative high drug loads could be achieved and sustained drug release can be provided over a period ofseveral days (etoposide) up to a few weeks (paclitaxel). While particle size exhibited only minor influences on the release kinetics, higher initial drug load led to a distinctly lower burst release. In a cancer cell culture model, etoposide or paclitaxel LNC showed a 4-fold or 40-fold higher efficiency, respectively than the drug solution while blank LNC were found to be less toxic than the pure drug at equivalent concentrations. The uptake and intracellular accumulation ofLNC was confirmed by confocal laser scanning microscopy after fluorescence labeling of the nanocarriers. This nanoparticulate system is able to achieve efficient intracellular drug concentrations and seems to be therefore a promising therapeutic approach in cancer treatment.

pH-Sensitive nanogates based on poly(l-histidine) for controlled drug release from mesoporous silica nanoparticles

2016 ◽  
Vol 7 (7) ◽  
pp. 1475-1485 ◽  
Author(s):  
Panayiotis Bilalis ◽  
Leto-A. Tziveleka ◽  
Spyridon Varlas ◽  
Hermis Iatrou
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Controlled Drug Release ◽  
Ph Sensitive ◽  
Ph Responsive

Mesoporous silica nanoparticles (MSNs) bearing poly(l-histidine)-grafted nanogates were prepared by surface-initiated ROP. The obtained polypeptide-functionalized MSNs were used as smart pH-responsive nanocarriers for controlled drug release applications.

A pH-responsive drug delivery system with an aggregation-induced emission feature for cell imaging and intracellular drug delivery

2015 ◽  
Vol 6 (26) ◽  
pp. 4715-4718 ◽  
Author(s):  
Haibo Wang ◽  
Gongyan Liu ◽  
Haiqi Gao ◽  
Yunbing Wang
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cell Imaging ◽  
Emission Feature ◽  
Ph Sensitive ◽  
Ph Responsive ◽  
Therapeutic Treatment ◽  
Aggregation Induced Emission ◽  
Intracellular Drug Delivery

A pH-sensitive fluorescent vehicle based on aggregation-induced emission (AIE) has been developed as a drug delivery system for simultaneous cell imaging and therapeutic treatment.

Construction of a novel pH-sensitive drug release system from mesoporous silica tablets coated with Eudragit

2011 ◽  
Vol 13 (3) ◽  
pp. 641-646 ◽  
Author(s):  
Yingpu Xu ◽  
Fengyu Qu ◽  
Yu Wang ◽  
Huiming Lin ◽  
Xiang Wu ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Ph Sensitive ◽  
Release System ◽  
Drug Release System

Bifunctional Succinylated ε-Polylysine-Coated Mesoporous Silica Nanoparticles for pH-Responsive and Intracellular Drug Delivery Targeting the Colon

2017 ◽  
Vol 9 (11) ◽  
pp. 9470-9483 ◽  
Author(s):  
Chau T. H. Nguyen ◽  
Richard I. Webb ◽  
Lynette K. Lambert ◽  
Ekaterina Strounina ◽  
Edward C. Lee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Ph Responsive ◽  
Intracellular Drug Delivery

A versatile stimulus-responsive metal–organic framework for size/morphology tunable hollow mesoporous silica and pH-triggered drug delivery

2017 ◽  
Vol 5 (11) ◽  
pp. 2126-2132 ◽  
Author(s):  
Zhen Zou ◽  
Siqi Li ◽  
Dinggeng He ◽  
Xiaoxiao He ◽  
Kemin Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Metal Organic Framework ◽  
Three Dimensional ◽  
Ph Responsive ◽  
Intracellular Drug Delivery ◽  
Stimulus Responsive ◽  
Metal Organic ◽  
Hollow Mesoporous Silica ◽  
Pore Blocker

The ZIF-8 is applied for the preparation of size tunable three-dimensional hollow mesoporous silica materials (HMSNs) and used as a novel pore blocker for pH-responsive intracellular drug delivery system by grafting it onto the HMSN.

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