Synergistic dual-pH responsive copolymer micelles for pH-dependent drug release

Nanoscale ◽  
2016 ◽  
Vol 8 (3) ◽  
pp. 1437-1450 ◽  
Author(s):  
Hongzhang Deng ◽  
Xuefei Zhao ◽  
Jinjian Liu ◽  
Jianhua Zhang ◽  
Liandong Deng ◽  
...  
Keyword(s):  
Drug Release ◽  
High Stability ◽  
Degradation Rate ◽  
Ph Responsive ◽  
Physiological Conditions ◽  
Ph Dependent ◽  
Copolymer Micelles ◽  
Acidic Degradation

Doxorubicin encapsulated into micelles of dual-pH responsive copolymer show fast acidic-degradation rate but high stability under physiological conditions.

scholarly journals Characterization and optimization of pH-responsive polymer nanoparticles for drug delivery to oral biofilms

2016 ◽  
Vol 4 (18) ◽  
pp. 3075-3085 ◽  
Author(s):  
Jiayi Zhou ◽  
Benjamin Horev ◽  
Geelsu Hwang ◽  
Marlise I. Klein ◽  
Hyun Koo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Drug Release ◽  
Polymer Nanoparticles ◽  
Ph Responsive ◽  
Molecular Weights ◽  
Responsive Polymer ◽  
Oral Biofilms ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles

Corona and core molecular weights of p(DMAEMA)-b-p(DMAEMA-co-BMA-co-PAA) block copolymer micelles can be tuned to enhance drug release in response to acidic milieus consistent with oral biofilms.

Synthesis of water-dispersible silicon-containing hydroxyapatite nanoparticles with adjustable degradation rates and their applications as pH-responsive drug carriers

RSC Advances ◽  
2016 ◽  
Vol 6 (115) ◽  
pp. 114852-114858 ◽  
Author(s):  
Kaili Lin ◽  
Na Zhang ◽  
Zhilan Yin ◽  
Yuhui Shen ◽  
Weibin Zhang
Keyword(s):  
Drug Release ◽  
Anticancer Drugs ◽  
Environmentally Friendly ◽  
Drug Carriers ◽  
Hydroxyapatite Nanoparticles ◽  
Ph Responsive ◽  
Water Dispersible ◽  
Degradation Rates ◽  
Ph Dependent ◽  
Environmentally Friendly Method

An environmentally friendly method was developed to synthesize water-dispersible Si-HAp nanoparticles with adjustable degradation rates, high loading capacities for anticancer drugs, and sustained and pH-dependent drug release properties.

pH-Responsive H-Type PMAA2 -b -HTPBN-b -PMAA2 Four-Arm Star Block Copolymer Micelles for PTX Drug Release

2015 ◽  
Vol 15 (10) ◽  
pp. 1411-1422 ◽  
Author(s):  
Yan-Ling Luo ◽  
Mei Han ◽  
Feng Xu ◽  
Ya-Shao Chen ◽  
Yong-Qin Zhang
Keyword(s):  
Block Copolymer ◽  
Drug Release ◽  
Ph Responsive ◽  
Star Block Copolymer ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles

Nanostructures for pH-sensitive Drug Delivery and Magnetic Resonance Contrast Enhancement Systems

2018 ◽  
Vol 25 (25) ◽  
pp. 3036-3057 ◽  
Author(s):  
Xiao Sun ◽  
Guilong Zhang ◽  
Zhengyan Wu
Keyword(s):  
Drug Delivery ◽  
Magnetic Resonance ◽  
Drug Release ◽  
Contrast Enhancement ◽  
General Strategy ◽  
Ph Responsive ◽  
Physicochemical Changes ◽  
Magnetic Resonance Contrast ◽  
Resonance Contrast ◽  
Magnetic Resonance Contrast Enhancement

According to the differences of microenvironments between tumors and healthy tissues, if the anticancer drugs or magnetic resonance contrast agents (MRCAs) can be controlled to precisely match physiological needs at targeted tumor sites, it is expected to acquire better therapeutic efficacy and more accurate diagnosis. Over the decade, stimuli-responsive nanomaterials have been a research hotspot for cancer treatment and diagnosis because they show many excellent functions, such as in vivo imaging, combined targeting drug delivery and systemic controlled release, extended circulation time, etc. Among the various stimuli nanosystems, pH-stimuli mode is regarded as the most general strategy because of solid tumors acidosis. When exposed to weakly acidic tumor microenvironment, pH-responsive nanoplatforms can generate physicochemical changes for their structure and surface characteristics, causing drug release or contrast enhancement. In this review, we focused on the designs of various pH-responsive nanoplatforms and discussed the mechanisms of controlled drug release or switch on-off in MRCAs. This review also discussed the efficacy of cellular internalization for these nanoplatforms via endocytosis of acidic tumor cell. Meanwhile, nanoplatforms response to acidic intracellular pH (such as endosome, lysosome) are discussed, along with approaches for improving drug release performance and magnetic resonance contrast enhancement. A greater understanding of these pH-responsive nanoplatforms will help design more efficient nanomedicine to address the challenges encountered in conventional diagnosis and chemotherapy.

Programming cell communications with pH-responsive DNA nanodevices

2021 ◽  
Author(s):  
Junjun Hou ◽  
Shitai Zhu ◽  
Ziwei Zhao ◽  
Jianlei Shen ◽  
Jie Chao ◽  
...  
Keyword(s):  
Cell Surface ◽  
Chain Structure ◽  
Ph Responsive ◽  
Double Chain ◽  
Physiological Conditions

The DNA nanoswitchs on cell surface could respond to the changes of pH under physiological conditions by switching from a three-chain structure to a double-chain structure, thus connecting another set...

scholarly journals pH-responsive antibodies for therapeutic applications

2021 ◽  
Vol 28 (1) ◽  
Author(s):  
Tomasz Klaus ◽  
Sameer Deshmukh
Keyword(s):  
Drug Delivery ◽  
Treatment Outcome ◽  
Tumor Microenvironment ◽  
Dependent Manner ◽  
Therapeutic Antibodies ◽  
Ph Responsive ◽  
Biologic Drugs ◽  
Car T ◽  
Ph Dependent ◽  
The Brain

AbstractTherapeutic antibodies are instrumental in improving the treatment outcome for certain disease conditions. However, to enhance their efficacy and specificity, many efforts are continuously made. One of the approaches that are increasingly explored in this field are pH-responsive antibodies capable of binding target antigens in a pH-dependent manner. We reviewed suitability and examples of these antibodies that are functionally modulated by the tumor microenvironment. Provided in this review is an update about antigens targeted by pH-responsive, sweeping, and recycling antibodies. Applicability of the pH-responsive antibodies in the engineering of chimeric antigen receptor T-cells (CAR-T) and in improving drug delivery to the brain by the enhanced crossing of the blood–brain barrier is also discussed. The pH-responsive antibodies possess strong treatment potential. They emerge as next-generation programmable engineered biologic drugs that are active only within the targeted biological space. Thus, they are valuable in targeting acidified tumor microenvironment because of improved spatial persistence and reduced on-target off-tumor toxicities. We predict that the programmable pH-dependent antibodies become powerful tools in therapies of cancer.

Reversibly cross-linked poly(ethylene glycol)–poly(amino acid)s copolymer micelles: a promising approach to overcome the extracellular stability versus intracellular drug release challenge

RSC Advances ◽  
2015 ◽  
Vol 5 (26) ◽  
pp. 20025-20034 ◽  
Author(s):  
Yuling Li ◽  
Sai Wang ◽  
Dandan Zhu ◽  
Yuling Shen ◽  
Baixiang Du ◽  
...  
Keyword(s):  
Amino Acid ◽  
Drug Release ◽  
Ethylene Glycol ◽  
Lipoic Acid ◽  
Triblock Copolymer ◽  
Intracellular Delivery ◽  
Poly Ethylene Glycol ◽  
Copolymer Micelles ◽  
Poly Ethylene ◽  
Copolymer Poly

Reversibly shell cross-linked micelles based on a lipoic acid (LA) decorated triblock copolymer poly(ethylene glycol)-b-poly(γ-benzyl-l-glutamate)-b-poly(l-phenylalanine) have been developed for efficient intracellular delivery of DOX.

Mitochondrial alkaline pH-responsive drug release mediated by Celastrol loaded glycolipid-like micelles for cancer therapy

Biomaterials ◽  
2018 ◽  
Vol 154 ◽  
pp. 169-181 ◽  
Author(s):  
Yanan Tan ◽  
Yun Zhu ◽  
Yue Zhao ◽  
Lijuan Wen ◽  
Tingting Meng ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Alkaline Ph ◽  
Ph Responsive

Preparation of pH ‐responsive cellulose nanofibril/sodium alginate based hydrogels for drug release

2021 ◽  
pp. 51647
Author(s):  
Yuhang Li ◽  
Cong Wang ◽  
Yunhao Luan ◽  
Wanyi Liu ◽  
Tiantian Chen ◽  
...  
Keyword(s):  
Drug Release ◽  
Sodium Alginate ◽  
Cellulose Nanofibril ◽  
Ph Responsive
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