scholarly journals Codelivery of dihydroartemisinin and doxorubicin in mannosylated liposomes for drug-resistant colon cancer therapy

2017 ◽  
Vol 38 (6) ◽  
pp. 885-896 ◽  
Author(s):  
Xue-jia Kang ◽  
Hui-yuan Wang ◽  
Hui-ge Peng ◽  
Bin-fan Chen ◽  
Wen-yuan Zhang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Therapy ◽  
Drug Resistant ◽  
Mannosylated Liposomes

scholarly journals PIK3C3 Inhibition Promotes Sensitivity to Colon Cancer Therapy by Inhibiting Cancer Stem Cells

Cancers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 2168
Author(s):  
Balawant Kumar ◽  
Rizwan Ahmad ◽  
Swagat Sharma ◽  
Saiprasad Gowrikumar ◽  
Mark Primeaux ◽  
...  
Keyword(s):  
Stem Cells ◽  
Colon Cancer ◽  
Cancer Therapy ◽  
Cancer Stem Cells ◽  
Side Population ◽  
Therapy Resistance ◽  
Fluorescent Reporter ◽  
Combination Treatments ◽  
Gsk 3Β ◽  
Resistance To Chemotherapy

Background: Despite recent advances in therapies, resistance to chemotherapy remains a critical problem in the clinical management of colorectal cancer (CRC). Cancer stem cells (CSCs) play a central role in therapy resistance. Thus, elimination of CSCs is crucial for effective CRC therapy; however, such strategies are limited. Autophagy promotes resistance to cancer therapy; however, whether autophagy protects CSCs to promote resistance to CRC-therapy is not well understood. Moreover, specific and potent autophagy inhibitors are warranted as clinical trials with hydroxychloroquine have not been successful. Methods: Colon cancer cells and tumoroids were used. Fluorescent reporter-based analysis of autophagy flux, spheroid and side population (SP) culture, and qPCR were done. We synthesized 36-077, a potent inhibitor of PIK3C3/VPS34 kinase, to inhibit autophagy. Combination treatments were done using 5-fluorouracil (5-FU) and 36-077. Results: The 5-FU treatment induced autophagy only in a subset of the treated colon cancer. These autophagy-enriched cells also showed increased expression of CSC markers. Co-treatment with 36-077 significantly improved efficacy of the 5-FU treatment. Mechanistic studies revealed that combination therapy inhibited GSK-3β/Wnt/β-catenin signaling to inhibit CSC population. Conclusion: Autophagy promotes resistance to CRC-therapy by specifically promoting GSK-3β/Wnt/β-catenin signaling to promote CSC survival, and 36-077, a PIK3C3/VPS34 inhibitor, helps promote efficacy of CRC therapy.

scholarly journals Magnetic gold nanoparticle-mediated small interference RNA silencing Bag-1 gene for colon cancer therapy

2015 ◽  
Vol 35 (2) ◽  
pp. 978-984 ◽  
Author(s):  
WENBAI HUANG ◽  
ZHAN'AO LIU ◽  
GUANZHOU ZHOU ◽  
AILING TIAN ◽  
NIANFENG SUN
Keyword(s):  
Colon Cancer ◽  
Cancer Therapy ◽  
Gold Nanoparticle ◽  
Rna Silencing ◽  
Small Interference Rna ◽  
Interference Rna

Codelivery for Paclitaxel and Bcl-2 Conversion Gene by PHB-PDMAEMA Amphiphilic Cationic Copolymer for Effective Drug Resistant Cancer Therapy

2017 ◽  
Vol 17 (11) ◽  
pp. 1700186 ◽  
Author(s):  
Xiaoyuan Wang ◽  
Sing Shy Liow ◽  
Qiaoqiong Wu ◽  
Chuang Li ◽  
Cally Owh ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Effective Drug ◽  
Drug Resistant

scholarly journals Pharmacological inhibition of USP7 promotes antitumor immunity and contributes to colon cancer therapy

2019 ◽  
Vol Volume 12 ◽  
pp. 609-617 ◽  
Author(s):  
Changqing Fu ◽  
Xiaojue Zhu ◽  
Peiqi Xu ◽  
Yonghao Li
Keyword(s):  
Colon Cancer ◽  
Cancer Therapy ◽  
Antitumor Immunity ◽  
Pharmacological Inhibition

Locked nucleic acid modified bi-specific aptamer-targeted nanoparticles carrying survivin antagonist towards effective colon cancer therapy

RSC Advances ◽  
2015 ◽  
Vol 5 (37) ◽  
pp. 29008-29016 ◽  
Author(s):  
Kislay Roy ◽  
Rupinder K. Kanwar ◽  
Chun Hei Antonio Cheung ◽  
Cassandra Lee Fleming ◽  
Rakesh N. Veedu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Nucleic Acid ◽  
Cancer Therapy ◽  
Cancer Cells ◽  
Locked Nucleic Acid ◽  
Targeted Nanoparticles ◽  
Target Cancer

EpCAM and nucleolin translocate into the cytoplasm and nucleus that facilitates enhanced uptake of nanocarrier to specifically target cancer cells.

Targeted and Sustained Corelease of Chemotherapeutics and Gene by Injectable Supramolecular Hydrogel for Drug-Resistant Cancer Therapy

2018 ◽  
Vol 40 (5) ◽  
pp. 1800117 ◽  
Author(s):  
Xuan Liu ◽  
Zibiao Li ◽  
Xian Jun Loh ◽  
Kaifeng Chen ◽  
Zhen Li ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Resistant ◽  
Supramolecular Hydrogel

Targeted delivery of miRNA-204-5p by PEGylated polymer nanoparticles for colon cancer therapy

Nanomedicine ◽  
2018 ◽  
Vol 13 (7) ◽  
pp. 769-785 ◽  
Author(s):  
Bo Zheng ◽  
Lu Chen ◽  
Chun-Chun Pan ◽  
Jian-Zhang Wang ◽  
Guang-Rong Lu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Therapy ◽  
Targeted Delivery ◽  
Polymer Nanoparticles
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