Solubility of Phenylacetic Acid,p-Hydroxyphenylacetic Acid,p-Aminophenylacetic Acid,p-Hydroxybenzoic Acid, and Ibuprofen in Pure Solvents

2002 ◽  
Vol 47 (6) ◽  
pp. 1379-1383 ◽  
Author(s):  
Sandra Gracin ◽  
Åke C. Rasmuson
Keyword(s):  
Phenylacetic Acid ◽  
Hydroxybenzoic Acid ◽  
Hydroxyphenylacetic Acid

Induction of plantlets in axenically cultivated rhizoids of Fucus spiralis

1984 ◽  
Vol 62 (8) ◽  
pp. 1616-1620 ◽  
Author(s):  
Lisbeth Fries
Keyword(s):  
Phenylacetic Acid ◽  
Dry Weight ◽  
Hydroxybenzoic Acid ◽  
Dihydroxybenzoic Acid ◽  
Indolylacetic Acid ◽  
Plantlet Formation ◽  
Carbon Compounds ◽  
Hydroxyphenylacetic Acid ◽  
Fucus Spiralis ◽  
Active Substances

Rhizoids of Fucus spiralis were cultivated axenically in the artificial seawater ASP6 F2. Experiments were made to increase the filamental growth as well as to induce adventive primordia (plantlets). Additions of such carbon compounds as glucose, acetate, and formate had no favourable effects even in concentrations as low as 1∙10−4 M. Mannitol killed the rhizoids in higher concentrations and inhibited growth even in a concentration as low as 1∙10−5 M. Higher concentrations of glycerol also inhibited growth, but 1∙10−4 M was an exception as it initiated plantlets. Many simple phenolic compounds induced plantlets. Among the most active substances were phenylacetic acid, p-hydroxyphenylacetic acid, 3,4-dihydroxybenzoic acid, o-hydroxybenzoic acid, and o-acetoxybenzoic acid, with optimal effects in the concentration range of 1∙10−7 to 1∙10−6 M. β-Indolylacetic acid strongly influenced the dry weight as well as plantlet formation at concentrations of 1∙10−8 to 1∙10−7 M, with 1∙10−8 M favouring plantlet induction. It is obvious that β-indolylacetic acid plays an important role in the earlier stages of the development of Fucus.

scholarly journals Anti-aggregation Effects of Phenolic Compounds on α-synuclein

Molecules ◽  
2020 ◽  
Vol 25 (10) ◽  
pp. 2444
Author(s):  
Kenjiro Ono ◽  
Mayumi Tsuji ◽  
Tritia R. Yamasaki ◽  
Giulio M. Pasinetti
Keyword(s):  
Phenolic Compounds ◽  
Gut Microbiota ◽  
Lewy Bodies ◽  
Hydroxybenzoic Acid ◽  
Dietary Polyphenols ◽  
Pathologic Features ◽  
Hydroxyphenylacetic Acid ◽  
A Cell ◽  
The Brain

The aggregation and deposition of α-synuclein (αS) are major pathologic features of Parkinson’s disease, dementia with Lewy bodies, and other α-synucleinopathies. The propagation of αS pathology in the brain plays a key role in the onset and progression of clinical phenotypes. Thus, there is increasing interest in developing strategies that attenuate αS aggregation and propagation. Based on cumulative evidence that αS oligomers are neurotoxic and critical species in the pathogenesis of α-synucleinopathies, we and other groups reported that phenolic compounds inhibit αS aggregation including oligomerization, thereby ameliorating αS oligomer-induced cellular and synaptic toxicities. Heterogeneity in gut microbiota may influence the efficacy of dietary polyphenol metabolism. Our recent studies on the brain-penetrating polyphenolic acids 3-hydroxybenzoic acid (3-HBA), 3,4-dihydroxybenzoic acid (3,4-diHBA), and 3-hydroxyphenylacetic acid (3-HPPA), which are derived from gut microbiota-based metabolism of dietary polyphenols, demonstrated an in vitro ability to inhibit αS oligomerization and mediate aggregated αS-induced neurotoxicity. Additionally, 3-HPPA, 3,4-diHBA, 3-HBA, and 4-hydroxybenzoic acid significantly attenuated intracellular αS seeding aggregation in a cell-based system. This review focuses on recent research developments regarding neuroprotective properties, especially anti-αS aggregation effects, of phenolic compounds and their metabolites by the gut microbiome, including our findings in the pathogenesis of α-synucleinopathies.

Degradation of the Isoflavone Biochanin A-7-O-glucoside-6"O-inalonate and Phenylacetic Acids by Fusarium javanicum

1984 ◽  
Vol 39 (9-10) ◽  
pp. 882-887 ◽  
Author(s):  
Dittmar Schlieper ◽  
Dieter Komoßa ◽  
Wolfgang Barz
Keyword(s):  
Phenylacetic Acid ◽  
Biochanin A ◽  
Acid Degradation ◽  
Hydroxyphenylacetic Acid

Keywords The isoflavone conjugate biochanin A-7-O-glucoside-6″-O-malonate is degraded by Fusarium javanicum with an esterase to yield biochanin A-7-O-glucoside which is further cleaved by a glucosidase to the aglycone. Biochanin A is funnelled into a known catabolic sequence (Z. Naturforsch. 37c, 861 (1982)). Induction of the catabolism of p-methoxyphenylacetic acid is linked to biochanin A degradation, whereas p-hydroxyphenylacetic acid and 3,4-dihydroxy- phenylacetic acid degradation is substrate-induced.

scholarly journals Catabolism of aromatics in Pseudomonas putida U. Formal evidence that phenylacetic acid and 4-hydroxyphenylacetic acid are catabolized by two unrelated pathways

1994 ◽  
Vol 221 (1) ◽  
pp. 375-381 ◽  
Author(s):  
Elias R. OLIVERA ◽  
Angel REGLERO ◽  
Honorina MARTINEZ-BLANCO ◽  
Alberto FERNANDEZ-MEDARDE ◽  
Miguel A. MORENO ◽  
...  
Keyword(s):  
Pseudomonas Putida ◽  
Phenylacetic Acid ◽  
Hydroxyphenylacetic Acid

Formation of p-hydroxybenzoic acid from phenylacetic acid by Poria weirii

1973 ◽  
Vol 51 (4) ◽  
pp. 827-828 ◽  
Author(s):  
C. Y. Li ◽  
K. C. Lu ◽  
J. M. Trappe ◽  
W. B. Bollen
Keyword(s):  
Phenylacetic Acid ◽  
Hydroxybenzoic Acid ◽  
Unknown Compound

Phenylacetic acid is known to inhibit growth of Poria weirii cultures at concentrations of 2.0 mM but not at 0.5 mM. In this study, the compound at the lower concentration was metabolized by the fungus by degradation to noninhibitory p-hydroxybenzoic acid and an unknown compound.

scholarly journals Biosynthesis of phytoquinones. Homogentisic acid: a precursor of plastoquinones, tocopherols and α-tocopherolquinone in higher plants, green algae and blue–green algae

1970 ◽  
Vol 117 (3) ◽  
pp. 593-600 ◽  
Author(s):  
G. R. Whistance ◽  
D. R. Threlfall
Keyword(s):  
Green Algae ◽  
Phenylacetic Acid ◽  
Higher Plants ◽  
Chlorella Pyrenoidosa ◽  
Homogentisic Acid ◽  
Side Chain ◽  
Methyl Groups ◽  
Blue Green Algae ◽  
Hydroxyphenylacetic Acid ◽  
Tracer Experiments

1. By means of 14C tracer experiments and isotope competition experiments the roles of d-tyrosine, p-hydroxyphenylpyruvic acid, p-hydroxyphenylacetic acid, phenylacetic acid, homogentisic acid and homoarbutin (2-methylquinol 4-β-d-glucoside) in the biosynthesis of plastoquinones, tocopherols and α-tocopherolquinone by maize shoots was investigated. It was established that d-tyrosine, p-hydroxyphenylpyruvic acid and homogentisic acid can all be utilized for this purpose, whereas p-hydroxyphenylacetic acid, phenylacetic acid and homoarbutin cannot. Studies on the mode of incorporation of d-tyrosine, p-hydroxyphenylpyruvic acid and homogentisic acid showed that their nuclear carbon atoms and the side-chain carbon atom adjacent to the nucleus give rise (as a C6-C1 unit) to the p-benzoquinone rings and nuclear methyl groups (one in each case) of plastoquinone-9 and α-tocopherolquinone and the aromatic nuclei and nuclear methyl groups (one in each case) of γ-tocopherol and α-tocopherol. 2. By using [14C]-homogentisic acid it has been shown that homogentisic acid is also a precursor of plastoquinone, tocopherols and α-tocopherolquinone in the higher plants Lactuca sativa and Rumex sanguineus, the green algae Chlorella pyrenoidosa and Euglena gracilis and the blue–green alga Anacystis nidulans.

scholarly journals Autotoxicity in Some Ornamentals with the Means to Overcome It

HortScience ◽  
2007 ◽  
Vol 42 (6) ◽  
pp. 1346-1350 ◽  
Author(s):  
Toshiki Asao ◽  
Hiroaki Kitazawa ◽  
Kazuyori Ushio ◽  
Yukio Sueda ◽  
Takuya Ban ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Benzoic Acid ◽  
Nutrient Solution ◽  
Root Exudates ◽  
Hydroxybenzoic Acid ◽  
Growth Inhibitors ◽  
Hydroxyphenylacetic Acid ◽  
Prairie Gentian ◽  
Pot Marigold ◽  
Sweet Pea

Autotoxicity in some ornamentals was investigated. The plants were grown by hydroponics with or without the addition of activated charcoal (AC) to the nutrient solution. The AC was used to trap the exuded organics from roots. Among the 37 plants under study, growth of lily, prairie gentian, corn poppy, farewell-to-spring, rocket larkspur, and carnation was drastically reduced in the absence of AC compared with those in the presence of AC in the nutrient solution. Root exudates of some plants were analyzed and several organic compounds were detected. The strong growth inhibitors such as lactic acid in pot marigold, benzoic and p-hydroxybenzoic acid in lily, o-hydroxyphenylacetic acid in rocket larkspur, benzoic and p-hydroxybenzoic acid in sweet pea, and maleic and benzoic acid in prairie gentian were detected in the root exudates. The reduced growth of prairie gentian after prolonged cultivation in a field might be avoided by amending the soil with AC at a rate of 60 kg·10a−1.

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