preparative route
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Molecules ◽  
2020 ◽  
Vol 25 (5) ◽  
pp. 1223 ◽  
Author(s):  
Lucia Tamborini ◽  
Clelia Previtali ◽  
Francesca Annunziata ◽  
Teodora Bavaro ◽  
Marco Terreni ◽  
...  

The bi-enzymatic synthesis of the antiviral drug vidarabine (arabinosyladenine, ara-A), catalyzed by uridine phosphorylase from Clostridium perfringens (CpUP) and a purine nucleoside phosphorylase from Aeromonas hydrophila (AhPNP), was re-designed under continuous-flow conditions. Glyoxyl–agarose and EziGTM1 (Opal) were used as immobilization carriers for carrying out this preparative biotransformation. Upon setting-up reaction parameters (substrate concentration and molar ratio, temperature, pressure, residence time), 1 g of vidarabine was obtained in 55% isolated yield and >99% purity by simply running the flow reactor for 1 week and then collecting (by filtration) the nucleoside precipitated out of the exiting flow. Taking into account the substrate specificity of CpUP and AhPNP, the results obtained pave the way to the use of the CpUP/AhPNP-based bioreactor for the preparation of other purine nucleosides.


2018 ◽  
Vol 28 (39) ◽  
pp. 1803801 ◽  
Author(s):  
Hyo Joong Lee ◽  
Kyung Taek Cho ◽  
Sanghyun Paek ◽  
Yonghui Lee ◽  
Aron J. Huckaba ◽  
...  

2017 ◽  
Vol 9 (4) ◽  
pp. 431-447 ◽  
Author(s):  
F. Begum ◽  
S. A. Jahan ◽  
M. Y. A. Mollah ◽  
M. M. Rahman ◽  
M. A. B. H. Susan

Water in oil (W/O) microemulsions are simple preparative route for nanoparticles where water droplets dispersed in oil stabilized by surfactant or surfactant and cosurfactant monolayer act as nanoreactors to carry out chemical reactions. In this work, silver nanoparticles (AgNPs) were prepared in W/O microemulsions of cetyltrimethylammonium bromide (CTAB) and triton X-100 (TX-100) by using AgNO3 and NaBH4 as a precursor salt and reducing agent, respectively. To prepare microemulsions, CTAB or TX-100, 1-pentanol, cyclohexane and water were mixed with different molar ratio. AgNPs were prepared with different [AgNO3] in microemulsions of CTAB with fixed water to surfactant ratio (Wo). Average particle sizes were determined from dynamic light scattering (DLS) measurements. AgNPs prepared from microemulsions of CTAB were unstable while from TX-100, NPs were stable. Aggregation kinetics was investigated by measuring the absorbance at definite time intervals at the absorption maximum, ?max of AgNPs in different media under pseudo-first-order conditions. The aggregation behavior was studied at different [AgNO3]:[NaBH4] and Wo and the parameters were optimized to ensure formation of stable AgNPs without aggregation in microemulsions. This would help tuning the size, stability, and aggregation kinetics of AgNPs by controlling the nature of the surfactant and composition of the microemulsions.


2017 ◽  
Vol 46 (5) ◽  
pp. 1357-1367 ◽  
Author(s):  
Tristram Chivers ◽  
Risto S. Laitinen

The cyclocondensation reaction of primary amines with pnictogen and chalcogen halides is a major preparative route for the generation of inorganic heterocycles involving a Group 15 or 16 element linked to nitrogen.


Langmuir ◽  
2015 ◽  
Vol 31 (33) ◽  
pp. 9260-9260
Author(s):  
Junhyung Kim ◽  
Kesta Lema ◽  
Macmillan Ukaigwe ◽  
Dongil Lee

Tetrahedron ◽  
2011 ◽  
Vol 67 (31) ◽  
pp. 5656-5662 ◽  
Author(s):  
Conrad Fischer ◽  
Guisheng Lin ◽  
Wilhelm Seichter ◽  
Edwin Weber

2010 ◽  
Vol 98 (1) ◽  
pp. 77-82 ◽  
Author(s):  
D. Badía ◽  
E. Domínguez ◽  
J. Galarza ◽  
E. Lete ◽  
E. Martínez De Marigorta ◽  
...  
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