Synthesis of Mesoporous CuO Hollow Sphere Nanozyme for Paper-Based Hydrogen Peroxide Sensor

Point-of-care monitoring of hydrogen peroxide is important due to its wide usage in biomedicine, the household and industry. Herein, a paper sensor is developed for sensitive, visual and selective detection of H2O2 using a mesoporous metal oxide hollow sphere as a nanozyme. The mesoporous CuO hollow sphere is synthesized by direct decomposition of copper–polyphenol colloidal spheres. The obtained mesoporous CuO hollow sphere shows a large specific surface area (58.77 m2/g), pore volume (0.56 cm3/g), accessible mesopores (5.8 nm), a hollow structure and a uniform diameter (~100 nm). Furthermore, they are proven to show excellent peroxidase-like activities with Km and Vmax values of 120 mM and 1.396 × 10−5 M·s−1, respectively. Such mesoporous CuO hollow spheres are then loaded on the low-cost and disposable filter paper test strip. The obtained paper sensor can be effectively used for detection of H2O2 in the range of 2.4–150 μM. This work provides a new kind of paper sensor fabricated from a mesoporous metal oxide hollow sphere nanozyme. These sensors could be potentially used in bioanalysis, food security and environmental protection.

A comparative electrochemical study of non-enzymatic glucose, ascorbic acid, and albumin detection by using a ternary mesoporous metal oxide (ZrO2, SiO2 and In2O3) modified graphene composite based biosensor

In this study, we present an electrochemical investigation of a ternary mesoporous metal oxide (ZrO2, SiO2 and In2O3) modified graphene composite for non-enzymatic glucose, ascorbic acid, and albumin detection in urine at physiological pH.

Robotic Catalysis: A High-Throughput Method for Miniature Screening of Mesoporous Metal Oxides

A high-throughput method for the screening of miniature mesoporous metal oxide oxidation catalysts were developed. This was achieved by using multiple robotic techniques including 3D printing. The catalysts (Co₃O₄, Au/Co₃O₄, Pd/Co₃O₄ and Co/Mn mesoporous metal oxides) were screened for their activity towards the oxidation of morin.