Pre-CAD-Frication: Re-establishing Automotive Paradigms to a Manufactured Architecture

<p>Through the late Twentieth Century, leading vehicle manufacturers increasingly eschewed the drive from mass production and instead focused upon lean production, where output has been determined according to demand. Automotive manufacturers no longer stockpile parts, but vehicles are now made to order, and in doing so the automotive industry has attained flexibility within production; a factor that has historically been unattainable with the simplistic rationalities of mass-production. Automotive manufacturers are now guided with digital design tools, and have further addressed the complexities of flexible production and the modular composition of the 21st Century automobile. Through the utilisation of digital design tools, digital collaboration, organisational capabilities and product technologies the 21st century automobile has successfully shown the world that highly complex products can be produced both efficiently and effectively, with versatility and high craft. The building industry has not been so swift to exploit the opportunities offered by digital lean production; often still constructing in the same laborious manner it has done so for hundreds of years. Digital lean production offers strategies for exerting efficient, sustainable design within contemporary architecture. Through the design of a flexible dwelling, this thesis establishes how the principles of digital, lean production can be utilised within Building Information Modeling to address the issues of speed and precision within the design and manufacture of contemporary architecture.</p>

Pre-CAD-Frication: Re-establishing Automotive Paradigms to a Manufactured Architecture

<p>Through the late Twentieth Century, leading vehicle manufacturers increasingly eschewed the drive from mass production and instead focused upon lean production, where output has been determined according to demand. Automotive manufacturers no longer stockpile parts, but vehicles are now made to order, and in doing so the automotive industry has attained flexibility within production; a factor that has historically been unattainable with the simplistic rationalities of mass-production. Automotive manufacturers are now guided with digital design tools, and have further addressed the complexities of flexible production and the modular composition of the 21st Century automobile. Through the utilisation of digital design tools, digital collaboration, organisational capabilities and product technologies the 21st century automobile has successfully shown the world that highly complex products can be produced both efficiently and effectively, with versatility and high craft. The building industry has not been so swift to exploit the opportunities offered by digital lean production; often still constructing in the same laborious manner it has done so for hundreds of years. Digital lean production offers strategies for exerting efficient, sustainable design within contemporary architecture. Through the design of a flexible dwelling, this thesis establishes how the principles of digital, lean production can be utilised within Building Information Modeling to address the issues of speed and precision within the design and manufacture of contemporary architecture.</p>

A Transcriptome Community-and-Module Approach of the Human Mesoconnectome

Graph analysis allows exploring transcriptome compartments such as communities and modules for brain mesostructures. In this work, we proposed a bottom-up model of a gene regulatory network to brain-wise connectome workflow. We estimated the gene communities across all brain regions from the Allen Brain Atlas transcriptome database. We selected the communities method to yield the highest number of functional mesostructures in the network hierarchy organization, which allowed us to identify specific brain cell functions (e.g., neuroplasticity, axonogenesis and dendritogenesis communities). With these communities, we built brain-wise region modules that represent the connectome. Our findings match with previously described anatomical and functional brain circuits, such the default mode network and the default visual network, supporting the notion that the brain dynamics that carry out low- and higher-order functions originate from the modular composition of a GRN complex network

Rapid and High-Throughput Evaluation of Diverse Configurations of Engineered Lysins Using the VersaTile Technique

Bacteriophage-encoded lysins are an emerging class of antibacterial enzymes based on peptidoglycan degradation. The modular composition of lysins is a hallmark feature enabling optimization of antibacterial and pharmacological properties by engineering of lysin candidates based on lysin and non-lysin modules. In this regard, the recent introduction of the VersaTile technique allows the rapid construction of large modular lysin libraries based on a premade repository of building blocks. In this study, we perform a high-throughput construction and screening of five combinatorial lysin libraries with different configurations, targeting Klebsiella pneumoniae. An elaborate analysis of the activity distribution of 940 variants and sequencing data of 74 top hits inhibiting the growth of Klebsiella pneumoniae could be associated with specific design rules. Specific outer membrane permeabilizing peptides (OMPs) and enzymatically active domains (EADs) are significantly overrepresented among the top hits, while cell wall binding domains (CBDs) are equally represented. Especially libraries with the configuration (OMP–linker–CBD–EAD) and the inverse configuration (CBD–EAD–linker–OMP) yield the most active variants, with discernible clusters of variants that emerge above the remaining variants. The approach implemented here provides a blueprint for discovery campaigns of engineered lysins starting from libraries with different configurations and compositions.

ON ONE APPROACH TO IMPLEMENTATION OF INFORMATION INFRASTRUCTURE FOR RENEWABLE INFORMATION SEARCH

Major tasks in the field of information technology that business faces today one way or another relate to data processing and search for new information in it. The methods in use include statistical methods, machine learning models, and simpler methods and models. However, all solutions aimed at information search require an information infrastructure that would meet the basic requirements for systems of this kind. The purpose of the study was to describe the main functional and technical requirements to modern systems implementing renewable information search. The author meant to form fundamental architectural proposals for the design of the system as a whole and its key parts, as well as to identify the main components of the information system and approaches to solving key problems for solutions based on the message exchange mechanism. Materials and methods. The paper considers the modern statement of the problem of creating enterprise information systems for renewable information search. The author compares message brokers that are viewed as the most interesting in the framework of this statement. Results. The article substantiates the relevance of the problem of creating information systems for renewable information search and formulates the task to create a system of such kind. The author makes an overview of the architecture design of the solution at a high level of abstraction. The modular composition of the information system under consideration is discussed. Kafka is chosen and substantiated as the most suitable message broker. The nuances of technical solutions to eliminate duplicate records and filter the latest information search results are analyzed.

STUDY OF PROCESSING THE SHELLS AS EMBELLISHMENT MATERIAL WITH BEADING TECHNIQUES

There are 4 shell processing in the creative industry world is an innovation of surface embellishment design with the application of beading techniques. Utilization of each character shells good surface shape and color, further for processing shell clams that such kind of scallop and abalone, where both types of shells have significantly differenced and produce variations. This research methods using the comparative method by examining the results of exploration based on shell shape characters, modular composition, color characters and application techniques. The results of this study are information that these two types of shells are innovations of variations in material embellishment by means of processing, proper techniques and utilizing the character of each shell will provide more value as a surface design. It’s hoped to be beneficial to the creative industry worlds as a variety sustainable material.

The craniomandibular anatomy of the early archosauriform Euparkeria capensis and the dawn of the archosaur skull

Archosauria (birds, crocodilians and their extinct relatives) form a major part of terrestrial ecosystems today, with over 10 000 living species, and came to dominate the land for most of the Mesozoic (over 150 Myr) after radiating following the Permian–Triassic extinction. The archosaur skull has been essential to this diversification, itself diversified into myriad forms. The archosauriform Euparkeria capensis from the Middle Triassic (Anisian) of South Africa has been of great interest since its initial description in 1913, because its anatomy shed light on the origins and early evolution of crown Archosauria and potentially approached that of the archosaur common ancestor. Euparkeria has been widely used as an outgroup in phylogenetic analyses and when investigating patterns of trait evolution among archosaurs. Although described monographically in 1965, subsequent years have seen great advances in the understanding of early archosaurs and in imaging techniques. Here, the cranium and mandible of Euparkeria are fully redescribed and documented using all fossil material and computed tomographic data. Details previously unclear are fully described, including vomerine dentition, the epiptergoid, number of premaxillary teeth and palatal arrangement. A new diagnosis and cranial and braincase reconstruction is provided, and an anatomical network analysis is performed on the skull of Euparkeria and compared with other amniotes. The modular composition of the cranium suggests a flexible skull well adapted to feeding on agile food, but with a clear tendency towards more carnivorous behaviour, placing the taxon at the interface between ancestral diapsid and crown archosaur ecomorphology, corresponding to increases in brain size, visual sensitivity, upright locomotion and metabolism around this point in archosauriform evolution. The skull of Euparkeria epitomizes a major evolutionary transition, and places crown archosaur morphology in an evolutionary context.

Synthesis, Modular Composition, and Electrochemical Properties of Lamellar Iron SulfidesSynthesis, Modular Composition, and Electrochemical Properties of Lamellar Iron Sulfides

Transition metal chalcogenides with layered structures have emerged as promising materials for energy storage, catalysis, and electronics, among other areas. We have identified a new layered phase of iron sulfide containing interlayer solvated cations. We present an optimized synthesis for the Li+-containing material from an Fe(III) xanthate complex. Structure and composition data indicate the material consists of poorly-ordered iron sulfide layers separated by solvated cations. The lamellar spacing in these materials can be tuned by changing the identity of the cation. Furthermore, the lamellar spacing can also be reversibly tuned by the degree of solvation of the material. The material is electrically conductive and can serve as a pseudocapacitor with comparable performance to commercial materials such as MnO₂. Furthermore, these materials also show promise as lithium or sodium ion battery cathodes with good capacity and reversibility.