scholarly journals Systemic Delivery of Small Interfering RNA Therapeutics: Obstacles and Advances

2019 ◽  
Vol 7 (0) ◽  
pp. 10-28 ◽  
Author(s):  
Akash Chandela ◽  
Yoshihito Ueno
Keyword(s):  
Small Interfering Rna ◽  
Systemic Delivery ◽  
Interfering Rna

scholarly journals Nanomedical Devices and Cancer Theranostics

2020 ◽  
Vol 6 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Mohamed Moumaris ◽  
Jean-Michel Bretagne ◽  
Nisen Abuaf
Keyword(s):  
Quantum Dot ◽  
Small Interfering Rna ◽  
Target Genes ◽  
Malignant Tumors ◽  
Whole Body ◽  
Systemic Delivery ◽  
Non Invasive ◽  
Current Therapies ◽  
Cancer Theranostics ◽  
Interfering Rna

The current therapies against cancer showed limited success. Nanotechnology is a promising strategy for cancer tracking, diagnosis, and therapy. The hybrid nanotechnology assembled several materials in a multimodal system to develop multifunctional approaches to cancer treatment. The quantum dot and polymer are some of these hybrid nanoparticle platforms. The quantum dot hybrid system possesses photonic and magnetic properties, allowing photothermal therapy and live multimodal imaging of cancer. These quantum dots were used to convey medicines to cancer cells. Hybrid polymer nanoparticles were utilized for the systemic delivery of small interfering RNA to malignant tumors and metastasis. They allowed non-invasive imaging to track in real-time the biodistribution of small interfering RNA in the whole body. They offer an opportunity to treat cancers by specifically silencing target genes. This review highlights the major nanotechnology approaches to effectively treat cancer and metastasis.

scholarly journals Design, synthesis and evaluation of novel, branched trident small interfering RNA nanostructures for sequence-specific RNAi activity

RSC Advances ◽  
2019 ◽  
Vol 9 (59) ◽  
pp. 34166-34171
Author(s):  
Akash Chandela ◽  
Yoshihito Ueno
Keyword(s):  
Gene Silencing ◽  
Small Interfering Rna ◽  
Target Gene ◽  
Physical Characterization ◽  
Small Interfering Rnas ◽  
Systemic Delivery ◽  
Design Synthesis ◽  
Serum Stability ◽  
Interfering Rna ◽  
Rnai Activity

Branched small interfering RNAs (siRNAs) are potential candidates for on-target gene silencing with enhanced serum stability. Their physical characterization also presents them as a prospective drug for systemic delivery.

scholarly journals Noninvasive Imaging of Lipid Nanoparticle–Mediated Systemic Delivery of Small-Interfering RNA to the Liver

2010 ◽  
Vol 18 (9) ◽  
pp. 1657-1666 ◽  
Author(s):  
Weikang Tao ◽  
Joseph P Davide ◽  
Mingmei Cai ◽  
Guo-Jun Zhang ◽  
Victoria J South ◽  
...  
Keyword(s):  
Small Interfering Rna ◽  
Noninvasive Imaging ◽  
Systemic Delivery ◽  
Lipid Nanoparticle ◽  
Interfering Rna

scholarly journals Systemic Delivery of Small Interfering RNA by Use of Targeted Polycation Liposomes for Cancer Therapy

2013 ◽  
Vol 36 (2) ◽  
pp. 287-291 ◽  
Author(s):  
Eriya Kenjo ◽  
Tomohiro Asai ◽  
Norihito Yonenaga ◽  
Hidenori Ando ◽  
Takayuki Ishii ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Small Interfering Rna ◽  
Systemic Delivery ◽  
Interfering Rna

scholarly journals Targeting Melanoma Growth and Metastasis with Systemic Delivery of Liposome-Incorporated Protease-Activated Receptor-1 Small Interfering RNA

2008 ◽  
Vol 68 (21) ◽  
pp. 9078-9086 ◽  
Author(s):  
Gabriel J. Villares ◽  
Maya Zigler ◽  
Hua Wang ◽  
Vladislava O. Melnikova ◽  
Hong Wu ◽  
...  
Keyword(s):  
Small Interfering Rna ◽  
Systemic Delivery ◽  
Protease Activated Receptor 1 ◽  
Interfering Rna ◽  
Melanoma Growth
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