scholarly journals Antihypertensive Effect and Safety of Dietary .ALPHA.-Linolenic Acid in Subjects with High-Normal Blood Pressure and Mild Hypertension

2007 ◽  
Vol 56 (7) ◽  
pp. 347-360 ◽  
Author(s):  
Hiroyuki Takeuchi ◽  
Chika Sakurai ◽  
Ryuuji Noda ◽  
Seiji Sekine ◽  
Yoshihiro Murano ◽  
...  
2005 ◽  
Vol 94 (1) ◽  
pp. 84-91 ◽  
Author(s):  
Seiichi Mizuno ◽  
Keiichi Matsuura ◽  
Takanobu Gotou ◽  
Shingo Nishimura ◽  
Osami Kajimoto ◽  
...  

We describe a clinical trial to study the efficacy of a casein hydrolysate, prepared using an Aspergillus oryzae protease, containing the major angiotensin-I-converting enzyme inhibitory peptides Val-Pro-Pro (VPP) and Ile-Pro-Pro (IPP) in a single-blind, placebo-controlled study. A total of 131 volunteers with high-normal blood pressure and mild hypertension were randomly divided into four groups (n 32 or 33 in each group). Each volunteer was given two tablets containing four different dosages of VPP and IPP (VPP+IPP: 0, 1·8, 2·5 and 3·6 mg), daily for 6 weeks. A significant decrease in systolic blood pressure was observed at 6 weeks in the active group receiving 1·8 mg (P<0·01) VPP and IPP; in the active groups receiving either 2·5 mg or 3·6 mg, systolic blood pressure was decreased at both 3 weeks (P<0·05 and P<0·05) and 6 weeks (P<0·001 and P<0·0001) compared with systolic blood pressure measured before treatment. Changes in the systolic blood pressure after 6 weeks of treatment in the four groups were −1·7, −6·3, −6·7 and −10·1 mmHg, and these effects were dose dependent. In addition, a significant difference in systolic blood pressure between the placebo group and the VPP and IPP group receiving 3·6 mg was observed (P<0·001) by two-way ANOVA. The antihypertensive effect was greater in mildly hypertensive subjects (n 20 or 21 in each group) than in any of the other subjects. No significant change of diastolic blood pressure was observed for all the test groups, and no differences in diastolic blood pressure in the test sample groups compared with the placebo group were observed during the test period.


2018 ◽  
Vol 36 ◽  
pp. e136-e137
Author(s):  
Yutaro Ogawa ◽  
Naohisa Shobako ◽  
Etsuko Kobayashi ◽  
Makoto Suwa ◽  
Motonobu Matsumoto ◽  
...  

2003 ◽  
Vol 56 (2) ◽  
pp. 97-102 ◽  
Author(s):  
Takashi Tsuchida ◽  
Kento Mashiko ◽  
Katsuhiko Yamada ◽  
Hideo Hiratsuka ◽  
Takao Shimada ◽  
...  

2005 ◽  
Vol 24 (4) ◽  
pp. 257-265 ◽  
Author(s):  
Kotaro Aihara ◽  
Osami Kajimoto ◽  
Hiroshi Hirata ◽  
Rei Takahashi ◽  
Yasunori Nakamura

2013 ◽  
Vol 77 (4) ◽  
pp. 691-696 ◽  
Author(s):  
Tomomi KOUGUCHI ◽  
Takashi OHMORI ◽  
Muneshige SHIMIZU ◽  
Yoshihisa TAKAHATA ◽  
Yoshiaki MAEYAMA ◽  
...  

2006 ◽  
Vol 195 (6) ◽  
pp. S159
Author(s):  
Bassam Haddad ◽  
Stéphanie Deis ◽  
Christophe Masson ◽  
Gilles Kayem ◽  
Baha Sibai

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