scholarly journals Antihypertensive effect of casein hydrolysate in a placebo-controlled study in subjects with high-normal blood pressure and mild hypertension

2005 ◽  
Vol 94 (1) ◽  
pp. 84-91 ◽  
Author(s):  
Seiichi Mizuno ◽  
Keiichi Matsuura ◽  
Takanobu Gotou ◽  
Shingo Nishimura ◽  
Osami Kajimoto ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Placebo Group ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Antihypertensive Effect ◽  
Mild Hypertension ◽  
Casein Hydrolysate ◽  
Normal Blood ◽  
Controlled Study ◽  
Normal Blood Pressure

We describe a clinical trial to study the efficacy of a casein hydrolysate, prepared using an Aspergillus oryzae protease, containing the major angiotensin-I-converting enzyme inhibitory peptides Val-Pro-Pro (VPP) and Ile-Pro-Pro (IPP) in a single-blind, placebo-controlled study. A total of 131 volunteers with high-normal blood pressure and mild hypertension were randomly divided into four groups (n 32 or 33 in each group). Each volunteer was given two tablets containing four different dosages of VPP and IPP (VPP+IPP: 0, 1·8, 2·5 and 3·6 mg), daily for 6 weeks. A significant decrease in systolic blood pressure was observed at 6 weeks in the active group receiving 1·8 mg (P<0·01) VPP and IPP; in the active groups receiving either 2·5 mg or 3·6 mg, systolic blood pressure was decreased at both 3 weeks (P<0·05 and P<0·05) and 6 weeks (P<0·001 and P<0·0001) compared with systolic blood pressure measured before treatment. Changes in the systolic blood pressure after 6 weeks of treatment in the four groups were −1·7, −6·3, −6·7 and −10·1 mmHg, and these effects were dose dependent. In addition, a significant difference in systolic blood pressure between the placebo group and the VPP and IPP group receiving 3·6 mg was observed (P<0·001) by two-way ANOVA. The antihypertensive effect was greater in mildly hypertensive subjects (n 20 or 21 in each group) than in any of the other subjects. No significant change of diastolic blood pressure was observed for all the test groups, and no differences in diastolic blood pressure in the test sample groups compared with the placebo group were observed during the test period.

scholarly journals Rice Bran Supplement Containing A Functional Substance, the Novel Peptide Leu-Arg-Ala, has Anti-Hypertensive Effects: A Double-Blind, Randomized, Placebo-Controlled Study

Nutrients ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 726
Author(s):  
Ogawa ◽  
Shobako ◽  
Fukuhara ◽  
Satoh ◽  
Kobayashi ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Placebo Group ◽  
Adverse Events ◽  
Rice Bran ◽  
Test Group ◽  
Normal Blood ◽  
Controlled Study ◽  
The Novel ◽  
Normal Blood Pressure ◽  
Double Blind

The anti-hypertensive effect of processed rice bran (PRB) was recently reported, for which the novel peptide Leu-Arg-Ala (LRA) was identified as the functional substance. The purpose of this study was to assess the anti-hypertensive effects of a rice bran supplement containing PRB in individuals with high-normal blood pressure (systolic blood pressure (SBP): 130–139 mmHg and/or diastolic blood pressure (DBP): 85–89 mmHg) or grade 1 hypertension (SBP: 140–159 mmHg and/or DBP: 90–99 mmHg). One hundred individuals with high-normal blood pressure or grade 1 hypertension were recruited to participate in this double-blind, randomized, placebo-controlled study. Participants were randomly allocated to the placebo group (n = 50) or the test group (n = 50). Each group took four test tablets (43 μg LRA/day) or four placebo tablets daily. The decrease in blood pressure in the test group compared with the placebo group was the primary outcome. Adverse events were recorded and hematological/urinary parameters measured to determine the safety of the supplement, which was the secondary outcome. In total, 87 participants completed the study. The SBP of the test group at 12 weeks was significantly lower than that of the placebo group (p = 0.0497). No serious adverse events were observed. Daily consumption of a rice bran supplement containing PRB can safely improve mildly elevated blood pressure.

scholarly journals TERAPI TERTAWA DAN PERUBAHAN TEKANAN DARAH PADA MAHASISWA DI UNIVERSITAS ADVENT INDONESIA

2016 ◽  
Vol 2 (2) ◽  
pp. 187
Author(s):  
Tawarina Surbakti ◽  
Gilny Aileen Joan ◽  
Denny Ricky
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Normal Blood ◽  
Test Design ◽  
Normal Blood Pressure ◽  
Purposive Sampling ◽  
Average Value ◽  
Before And After ◽  
Post Test

ABSTRAK Penelitian ini dilatarbelakangi hasil penelitian Ramdhani (2013) yang menunjukan adanya perubahan penurunan tekanan darah yaitu setelah dilakukan terapi tertawa selama dua minggu sebanyak enam kali pemberian. Maka peneliti merasa perlu dilakukan uji ulang pemberian terapi tertawa pada tekanan darah normal dengan satu kali pemberian. Tujuan penelitian untuk menganalisis perbedaan tekanan darah sebelum dan sesudah pemberian terapi tertawa pada mahasiswa di Universitas Advent Indonesia. Desain penelitian yang digunakan dalam penelitian ini adalah penelitian eksperimen yang menggunakan One Group Pre-Test and Post-Test Design dengan melibatkan satu kelompok subjek. Intervensi dalam penelitian yang dilakukan ini adalah pemberian terapi tertawa selama 20 menit. Subjek penelitian ini berjumlah 30 orang mahasiswi di Universitas Advent Indonesia. Pengambilan sampel dilakukan dengan teknik purposive sampling. Hasil penelitian ini menunjukan bahwa nilai rata-rata tekanan darah pada mahasiswi di Universitas Advent Indonesia sebelum pemberian terapi tertawa yaitu dengan nilai tekanan darah sistolik adalah  115.6 mmHg dan nilai tekanan darah diastolik 75.0 mmHg. Nilai rata-rata tekanan darah sistolik sesudah pemberian terapi tertawa adalah  110.8 mmHg dan tekanan darah diastolik 73.8  mmHg. Nilai tekanan darah sebelum dan sesudah pemberian terapi tertawa mempunyai nilai yang signifikan pada nilai uji-t pada tekanan sistolik. Tekanan diastolik tidak terjadi perubahan yang signifikan.   Kata kunci: Tekanan darah normal, Terapi tertawa   ABSTRACT This research is based on the writing of Ramdhani (2013) showing that there is a change in blood pressure after given six times laughter therapy for two weeks. Researchers find it necessary to repeat the laugh therapy on person with normal blood pressure with one provision. The purpose of this research is to identify changes in blood pressure before and after given laugh therapy. The research design used in this study is One Group Pre-Test and Post-Test Design experimental research that uses. Intervention conducted in this research is laughing therapy for 20 minutes. Subjects of this research were 30 students of Adventist University of Indonesia. That were by purposive sampling technique. The results of this research showed that the average value of blood pressure in students of Universitas Advent Indonesia before given laugh therapy with a systolic blood pressure value of 115.6 mm Hg and diastolic blood pressure value of 75.0 mmHg. The average value of systolic blood pressure after the administration of laughter therapy was 110.8 mmHg and a diastolic blood pressure value of 73.8 mmHg. Systolic blood pressure values before and after administration of laughter therapy has a significant change but not with the diastolic. Keywords: Normal blood pressure value, Laugh therapy

scholarly journals Antihypertensive Effect and Safety of Dietary .ALPHA.-Linolenic Acid in Subjects with High-Normal Blood Pressure and Mild Hypertension

2007 ◽  
Vol 56 (7) ◽  
pp. 347-360 ◽  
Author(s):  
Hiroyuki Takeuchi ◽  
Chika Sakurai ◽  
Ryuuji Noda ◽  
Seiji Sekine ◽  
Yoshihiro Murano ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Linolenic Acid ◽  
Antihypertensive Effect ◽  
Mild Hypertension ◽  
Normal Blood ◽  
Normal Blood Pressure ◽  
Alpha Linolenic Acid

The Evaluation of the Changes In Blood Pressure and the Heart Rate in the Course of Applying Pearl Bath at Persons With the Normal Blood Pressure and Heart Rate

2020 ◽  
Vol 62 (3) ◽  
pp. 159-165
Author(s):  
Wiesław J. Kochański ◽  
Maciej Kochański ◽  
Adrianna Frankowska
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Systolic Blood Pressure ◽  
Cardiovascular System ◽  
Diastolic Blood Pressure ◽  
Normal Blood ◽  
Normal Blood Pressure ◽  
Male And Female ◽  
Basic Parameters ◽  
Pre Treatment

Aim: The aim of this study was to investigate the effect of pearl bath on basic parameters of the cardiovascular system in patients without hypertension Material and Methods: This study recruited 40 patients without hypertension (20 male and 20 female). All patients had their blood pressure and heart rate measured immediately before and during the procedure. Results: During the pearl bath HR increased by an average of 2.6 bpm (p=0,018355), and from the measurement before surgery by 5.5 bpm (p=0,000404). SBP decreased during the bath by 8.7 mmHg (p=0.000001), DBP by 4.8 mmHg (p=0,000727). SBP, DBP values for pre-treatment measurements decreased by 14.4 mmHg (p=0,000000) and 9.7 mmHg (p=0,000005), respectively. Conclusions: Pearl baths decreases blood pressure and increase pulse. The dynamics of changes in systolic blood pressure, diastolic blood pressure and heart rate do not differ significantly between male and female.

EFFECT OF SUBMAXIMAL EXERCISE ON SYSTOLIC AND DIASTOLIC BLOOD PRESSURE IN YOUNG SEDENTARY NORMOTENSIVE NEPALESE MEDICAL STUDENTS

2003 ◽  
Vol 42 (149) ◽  
pp. 315-6
Author(s):  
Arijit Ghosh ◽  
T Pramanik
Keyword(s):  
Blood Pressure ◽  
Medical Students ◽  
Diastolic Blood Pressure ◽  
Submaximal Exercise ◽  
Muscular Exercise ◽  
Normal Blood ◽  
Normal Blood Pressure ◽  
Standing Posture ◽  
Normal Range ◽  
Exercise Blood Pressure

Higher exercise blood pressure represents low cardiorespiratory status of an individual and vice versa. Thechanges in systolic and diastolic blood pressure in response to rhythmic isotonic muscular exercise in sedentaryyoung normotensive Nepalese students were assessed. Normal blood pressure in standing posture in maleand female subjects are about 115 / 75 mm of Hg. and 106 / 71 mm of Hg. respectively. Just after the exercisesystolic blood pressure increases moderately in both the sexes, whereas diastolic blood pressure remainsunchanged in most of the females. Diastolic blood pressure is found to be decreased slightly in the males,just after exercise. The present study indicates the cardiorespiratory status of the Napalese medical studentsis within normal range.

A2691 Anti-hypertensive effect of thermolysin-digested rice bran on high normal blood pressure and mild hypertension

2018 ◽  
Vol 36 ◽  
pp. e136-e137
Author(s):  
Yutaro Ogawa ◽  
Naohisa Shobako ◽  
Etsuko Kobayashi ◽  
Makoto Suwa ◽  
Motonobu Matsumoto ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Rice Bran ◽  
Mild Hypertension ◽  
Normal Blood ◽  
Normal Blood Pressure

scholarly journals Effects of the consumption of proanthocyanidins derived from acacia bark on blood pressure in healthy Japanese adults: A randomized, double-blind, placebo-controlled, parallel-group comparison study

2021 ◽  
Vol 11 (7) ◽  
pp. 310
Author(s):  
Asami Baba ◽  
Tomohiro Hoshino ◽  
Sosuke Ogawa ◽  
Tsuyoshi Takara
Keyword(s):  
Blood Pressure ◽  
Placebo Group ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Bark Extract ◽  
Comparison Study ◽  
Japanese Adult ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Japanese Adults

Objective: The aim of this study is to verify the effects of consuming proanthocyanidins derived from acacia bark on improving blood pressure and blood circulation in healthy Japanese adult subjects. Methods: This was a randomized, double-blind, placebo-controlled, parallel-comparison study involving 66 healthy Japanese adults. Subjects were allocated into either acacia or placebo group (n = 33 each) using a random number generator. Subjects consumed six tablets/day of either acacia bark extract tablets or placebo for 12 weeks. The primary outcome was the measured value of sitting systolic blood pressure at 12 weeks, whereas the secondary outcomes were sitting systolic and diastolic blood pressures, superoxide dismutase activity in blood, and blood flow.Results: The number of subjects analyzed as full analysis set was 33 (20 men and 13 women) in the Acacia group and 31 (23 men and 8 women) in the placebo group. Compared with the placebo group, the measured values and changes from baseline at 4, 8, and 12 weeks of the sitting systolic blood pressure were significantly lower in the Acacia group. Furthermore, “the ratio of the number of subjects whose sitting systolic blood pressure <130 mmHg and diastolic blood pressure ≤89 mmHg at 12 weeks” of the Acacia group was significantly higher than that of the placebo group. No adverse event was observed. Conclusions: Proanthocyanidins derived from acacia bark showed a hypotensive effect. Trial registration: UMIN-CTR: UMIN000039416. Foundation: Acacia-No-Ki Co., Ltd. Keywords: Acacia bark extract, Proanthocyanidins, Systolic blood pressure, Diastolic blood pressure

scholarly journals Clinical Study of .GAMMA.-Aminobutyric Acid-rich Chlorella for Subjects with High-normal Blood Pressure and Mild Hypertension

2003 ◽  
Vol 56 (2) ◽  
pp. 97-102 ◽  
Author(s):  
Takashi Tsuchida ◽  
Kento Mashiko ◽  
Katsuhiko Yamada ◽  
Hideo Hiratsuka ◽  
Takao Shimada ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Clinical Study ◽  
Mild Hypertension ◽  
Aminobutyric Acid ◽  
Normal Blood ◽  
Gamma Aminobutyric Acid ◽  
Normal Blood Pressure
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