Effect of an Excess Intake of Casein Hydrolysate Containing Val-Pro-Pro and Ile-Pro-Pro in Subjects with Normal Blood Pressure, High-Normal Blood Pressure, or Mild Hypertension

2011 ◽  
Vol 75 (3) ◽  
pp. 427-433 ◽  
Author(s):  
Yu ISHIDA ◽  
Yusuke SHIBATA ◽  
Ikuo FUKUHARA ◽  
Yuki YANO ◽  
Isao TAKEHARA ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Mild Hypertension ◽  
Casein Hydrolysate ◽  
Normal Blood ◽  
Normal Blood Pressure

scholarly journals Antihypertensive effect of casein hydrolysate in a placebo-controlled study in subjects with high-normal blood pressure and mild hypertension

2005 ◽  
Vol 94 (1) ◽  
pp. 84-91 ◽  
Author(s):  
Seiichi Mizuno ◽  
Keiichi Matsuura ◽  
Takanobu Gotou ◽  
Shingo Nishimura ◽  
Osami Kajimoto ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Placebo Group ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Antihypertensive Effect ◽  
Mild Hypertension ◽  
Casein Hydrolysate ◽  
Normal Blood ◽  
Controlled Study ◽  
Normal Blood Pressure

We describe a clinical trial to study the efficacy of a casein hydrolysate, prepared using an Aspergillus oryzae protease, containing the major angiotensin-I-converting enzyme inhibitory peptides Val-Pro-Pro (VPP) and Ile-Pro-Pro (IPP) in a single-blind, placebo-controlled study. A total of 131 volunteers with high-normal blood pressure and mild hypertension were randomly divided into four groups (n 32 or 33 in each group). Each volunteer was given two tablets containing four different dosages of VPP and IPP (VPP+IPP: 0, 1·8, 2·5 and 3·6 mg), daily for 6 weeks. A significant decrease in systolic blood pressure was observed at 6 weeks in the active group receiving 1·8 mg (P<0·01) VPP and IPP; in the active groups receiving either 2·5 mg or 3·6 mg, systolic blood pressure was decreased at both 3 weeks (P<0·05 and P<0·05) and 6 weeks (P<0·001 and P<0·0001) compared with systolic blood pressure measured before treatment. Changes in the systolic blood pressure after 6 weeks of treatment in the four groups were −1·7, −6·3, −6·7 and −10·1 mmHg, and these effects were dose dependent. In addition, a significant difference in systolic blood pressure between the placebo group and the VPP and IPP group receiving 3·6 mg was observed (P<0·001) by two-way ANOVA. The antihypertensive effect was greater in mildly hypertensive subjects (n 20 or 21 in each group) than in any of the other subjects. No significant change of diastolic blood pressure was observed for all the test groups, and no differences in diastolic blood pressure in the test sample groups compared with the placebo group were observed during the test period.

A2691 Anti-hypertensive effect of thermolysin-digested rice bran on high normal blood pressure and mild hypertension

2018 ◽  
Vol 36 ◽  
pp. e136-e137
Author(s):  
Yutaro Ogawa ◽  
Naohisa Shobako ◽  
Etsuko Kobayashi ◽  
Makoto Suwa ◽  
Motonobu Matsumoto ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Rice Bran ◽  
Mild Hypertension ◽  
Normal Blood ◽  
Normal Blood Pressure

scholarly journals Clinical Study of .GAMMA.-Aminobutyric Acid-rich Chlorella for Subjects with High-normal Blood Pressure and Mild Hypertension

2003 ◽  
Vol 56 (2) ◽  
pp. 97-102 ◽  
Author(s):  
Takashi Tsuchida ◽  
Kento Mashiko ◽  
Katsuhiko Yamada ◽  
Hideo Hiratsuka ◽  
Takao Shimada ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Clinical Study ◽  
Mild Hypertension ◽  
Aminobutyric Acid ◽  
Normal Blood ◽  
Gamma Aminobutyric Acid ◽  
Normal Blood Pressure

Effect of Powdered Fermented Milk withLactobacillus helveticuson Subjects with High-Normal Blood Pressure or Mild Hypertension

2005 ◽  
Vol 24 (4) ◽  
pp. 257-265 ◽  
Author(s):  
Kotaro Aihara ◽  
Osami Kajimoto ◽  
Hiroshi Hirata ◽  
Rei Takahashi ◽  
Yasunori Nakamura
Keyword(s):  
Blood Pressure ◽  
Mild Hypertension ◽  
Fermented Milk ◽  
Normal Blood ◽  
Normal Blood Pressure

Effects of a Chicken Collagen Hydrolysate on the Circulation System in Subjects with Mild Hypertension or High-Normal Blood Pressure

2013 ◽  
Vol 77 (4) ◽  
pp. 691-696 ◽  
Author(s):  
Tomomi KOUGUCHI ◽  
Takashi OHMORI ◽  
Muneshige SHIMIZU ◽  
Yoshihisa TAKAHATA ◽  
Yoshiaki MAEYAMA ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Mild Hypertension ◽  
Normal Blood ◽  
Circulation System ◽  
Normal Blood Pressure ◽  
Collagen Hydrolysate

scholarly journals Antihypertensive Effect and Safety of Dietary .ALPHA.-Linolenic Acid in Subjects with High-Normal Blood Pressure and Mild Hypertension

2007 ◽  
Vol 56 (7) ◽  
pp. 347-360 ◽  
Author(s):  
Hiroyuki Takeuchi ◽  
Chika Sakurai ◽  
Ryuuji Noda ◽  
Seiji Sekine ◽  
Yoshihiro Murano ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Linolenic Acid ◽  
Antihypertensive Effect ◽  
Mild Hypertension ◽  
Normal Blood ◽  
Normal Blood Pressure ◽  
Alpha Linolenic Acid

Are perinatal outcomes different in women with mild hypertension from those with normal blood pressure?

2006 ◽  
Vol 195 (6) ◽  
pp. S159
Author(s):  
Bassam Haddad ◽  
Stéphanie Deis ◽  
Christophe Masson ◽  
Gilles Kayem ◽  
Baha Sibai
Keyword(s):  
Blood Pressure ◽  
Mild Hypertension ◽  
Perinatal Outcomes ◽  
Normal Blood ◽  
Normal Blood Pressure

Influence of melatonin on blood pressure indicators with different severity of desynchronosis

2020 ◽  
pp. 30-40
Author(s):  
M. G. Melnik
Keyword(s):  
Blood Pressure ◽  
Circadian Rhythms ◽  
Antihypertensive Drugs ◽  
Blood Pressure Monitoring ◽  
Home Monitoring ◽  
Normal Blood ◽  
Normal Blood Pressure ◽  
Pronounced Decrease ◽  
The Third ◽  
Pressure Indicators

Purpose. To study the dynamics of blood pressure (BP) indicators under the influence of exogenously administered melatonin (Melatonin-SZ, Severnaya Zvezda, Russia) with various manifestations of desynchronosis of circadian BP rhythms (arterial hypertension – AH, high normal blood pressure) to determine the scheme of their effective compensation. Material and methods. The study included 101 patients with desynchronosis of circadian rhythms of blood pressure – 52 patients with hypertension, constituting the first and second groups, and 49 individuals with high normal blood pressure, representing the third and fourth groups. Patients of the second and fourth groups received conservative therapy, patients of the first and third groups combined it with melatonin. All patients underwent measurements of office blood pressure, home monitoring of blood pressure (ABPM), electrocardiography, 24-hour blood pressure monitoring (ABPM). Results and discussion. In patients of the first and third groups, compared with the traditional treatment groups, by the end of the observation period, a significantly (p < 0.05) decrease in office systolic blood pressure (SBP) / diastolic blood pressure (DBP) was established: in the first group compared with the second – 1.11 / 1.13 times, in the third group compared to the fourth – 1.43 / 1.58 times; significantly more (p < 0.05) pronounced decrease in SBP / DBP during DMAD – by 1.08 / 1.17 and 1.58 / 1.62 times, respectively, Significantly (p < 0.05) more pronounced decrease in average daily, average daily and average nighttime SBP / DBP during ABPM – by 1.13 / 1.20, 1.11 / 1.20, 1.23 / 1.25 and 1.47 / 1.31, 1.42 / 1.19, 1.54 / 1.41 times, respectively; reliably (p < 0.05) more frequent registration of the dipper rhythm type SBP / DBP – 1.6 / 1.4 and 1.6 / 1.4 times, respectively. In addition, the dynamics of patients in the first and third groups showed a significant (p < 0.05) decrease in the mean daily and mean nighttime SBP / DBP variability (SBP in the first group by 27.3 and 41.3 %, respectively; DBP in the first group by 20.1 and 26.3 %, respectively; SBP in the third group by 13.5 and 25.2 %, respectively; DBP in the third group by 12.2 and 28.2 %, respectively). Conclusions. With various manifestations of desynchronosis of circadian rhythms of blood pressure (AH, high normal blood pressure), the prescription of melatonin (Melatonin-SZ, Severnaya Zvezda, Russia) at a dose of 3 mg per day 30–40 minutes before bedtime for a month against the background of non-drug therapy and antihypertensive drugs led to a significantly more effective decrease in blood pressure at its office measurement, DMAD, ABPM with an improvement in the circadian rhythm of blood pressure and normalization of blood pressure variability.

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