scholarly journals Clinical Study of .GAMMA.-Aminobutyric Acid-rich Chlorella for Subjects with High-normal Blood Pressure and Mild Hypertension

2003 ◽  
Vol 56 (2) ◽  
pp. 97-102 ◽  
Author(s):  
Takashi Tsuchida ◽  
Kento Mashiko ◽  
Katsuhiko Yamada ◽  
Hideo Hiratsuka ◽  
Takao Shimada ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Clinical Study ◽  
Mild Hypertension ◽  
Aminobutyric Acid ◽  
Normal Blood ◽  
Gamma Aminobutyric Acid ◽  
Normal Blood Pressure

scholarly journals Hypotensive Effect of Fermented Milk Containing .GAMMA.-Aminobutyric Acid (GABA) in Subjects with High Normal Blood Pressure

2004 ◽  
Vol 51 (2) ◽  
pp. 79-86 ◽  
Author(s):  
Osami Kajimoto ◽  
Hiroshi Hirata ◽  
Satoshi Nakagawa ◽  
Yoshitaka Kajimoto ◽  
Kazuhito Hayakawa ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Hypotensive Effect ◽  
Fermented Milk ◽  
Aminobutyric Acid ◽  
Normal Blood ◽  
Gamma Aminobutyric Acid ◽  
Normal Blood Pressure

A2691 Anti-hypertensive effect of thermolysin-digested rice bran on high normal blood pressure and mild hypertension

2018 ◽  
Vol 36 ◽  
pp. e136-e137
Author(s):  
Yutaro Ogawa ◽  
Naohisa Shobako ◽  
Etsuko Kobayashi ◽  
Makoto Suwa ◽  
Motonobu Matsumoto ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Rice Bran ◽  
Mild Hypertension ◽  
Normal Blood ◽  
Normal Blood Pressure

Effect of Powdered Fermented Milk withLactobacillus helveticuson Subjects with High-Normal Blood Pressure or Mild Hypertension

2005 ◽  
Vol 24 (4) ◽  
pp. 257-265 ◽  
Author(s):  
Kotaro Aihara ◽  
Osami Kajimoto ◽  
Hiroshi Hirata ◽  
Rei Takahashi ◽  
Yasunori Nakamura
Keyword(s):  
Blood Pressure ◽  
Mild Hypertension ◽  
Fermented Milk ◽  
Normal Blood ◽  
Normal Blood Pressure

scholarly journals Antihypertensive effect of casein hydrolysate in a placebo-controlled study in subjects with high-normal blood pressure and mild hypertension

2005 ◽  
Vol 94 (1) ◽  
pp. 84-91 ◽  
Author(s):  
Seiichi Mizuno ◽  
Keiichi Matsuura ◽  
Takanobu Gotou ◽  
Shingo Nishimura ◽  
Osami Kajimoto ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Placebo Group ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Antihypertensive Effect ◽  
Mild Hypertension ◽  
Casein Hydrolysate ◽  
Normal Blood ◽  
Controlled Study ◽  
Normal Blood Pressure

We describe a clinical trial to study the efficacy of a casein hydrolysate, prepared using an Aspergillus oryzae protease, containing the major angiotensin-I-converting enzyme inhibitory peptides Val-Pro-Pro (VPP) and Ile-Pro-Pro (IPP) in a single-blind, placebo-controlled study. A total of 131 volunteers with high-normal blood pressure and mild hypertension were randomly divided into four groups (n 32 or 33 in each group). Each volunteer was given two tablets containing four different dosages of VPP and IPP (VPP+IPP: 0, 1·8, 2·5 and 3·6 mg), daily for 6 weeks. A significant decrease in systolic blood pressure was observed at 6 weeks in the active group receiving 1·8 mg (P<0·01) VPP and IPP; in the active groups receiving either 2·5 mg or 3·6 mg, systolic blood pressure was decreased at both 3 weeks (P<0·05 and P<0·05) and 6 weeks (P<0·001 and P<0·0001) compared with systolic blood pressure measured before treatment. Changes in the systolic blood pressure after 6 weeks of treatment in the four groups were −1·7, −6·3, −6·7 and −10·1 mmHg, and these effects were dose dependent. In addition, a significant difference in systolic blood pressure between the placebo group and the VPP and IPP group receiving 3·6 mg was observed (P<0·001) by two-way ANOVA. The antihypertensive effect was greater in mildly hypertensive subjects (n 20 or 21 in each group) than in any of the other subjects. No significant change of diastolic blood pressure was observed for all the test groups, and no differences in diastolic blood pressure in the test sample groups compared with the placebo group were observed during the test period.

Effects of a Chicken Collagen Hydrolysate on the Circulation System in Subjects with Mild Hypertension or High-Normal Blood Pressure

2013 ◽  
Vol 77 (4) ◽  
pp. 691-696 ◽  
Author(s):  
Tomomi KOUGUCHI ◽  
Takashi OHMORI ◽  
Muneshige SHIMIZU ◽  
Yoshihisa TAKAHATA ◽  
Yoshiaki MAEYAMA ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Mild Hypertension ◽  
Normal Blood ◽  
Circulation System ◽  
Normal Blood Pressure ◽  
Collagen Hydrolysate

scholarly journals Antihypertensive Effect and Safety of Dietary .ALPHA.-Linolenic Acid in Subjects with High-Normal Blood Pressure and Mild Hypertension

2007 ◽  
Vol 56 (7) ◽  
pp. 347-360 ◽  
Author(s):  
Hiroyuki Takeuchi ◽  
Chika Sakurai ◽  
Ryuuji Noda ◽  
Seiji Sekine ◽  
Yoshihiro Murano ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Linolenic Acid ◽  
Antihypertensive Effect ◽  
Mild Hypertension ◽  
Normal Blood ◽  
Normal Blood Pressure ◽  
Alpha Linolenic Acid
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