scholarly journals ATENÇÃO FARMACÊUTICA NO TRATAMENTO DE TUBERCULOSE

2021 ◽  
Vol 7 (8) ◽  
pp. 296-309
Author(s):  
Monique Teixeira Giacometti
Keyword(s):  
Mycobacterium Bovis ◽  
Tubercle Bacillus ◽  
Mycobacterium Africanum

A Tuberculose (TB) Peste branca ou como é popularmente conhecida, a tuberculose surgiu no continente africano há pelo menos 70.000 anos, acompanhou humanos na evolução e processo de expansão pelo planeta, mesmo hoje em dia considerada uma ameaça para à saúde. A TB é uma doença infecciosa crônica granulomatosa causada por bactérias do grupo das microbactérias. É importante ressaltar que existem microbactérias que podem causar tuberculose e outras que não podem. As principais causadoras são, da mais importante para a menos: tubercle bacillus, Mycobacterium bovis e Mycobacterium africanum. É considerada a doença mais infecciosa e mortal do mundo, responsável por mais de 04 mil mortes diárias no mundo todo, de acordo com a Organização Mundial da Saúde (OMS). Embora afete outros órgãos e / ou sistemas, é uma doença infecciosa e contagiosa que atinge principalmente os pulmões. As formas extrapulmonares que afetam outros órgãos além dos pulmões são mais comuns entre as pessoas com HIV, especialmente aquelas com sistema imunológico enfraquecido. No Brasil, a doença é um grave problema de saúde pública com profundas raízes sociais. A epidemia de HIV e a existência de bacilos resistentes a medicamentos complicaram a situação. Todos os anos, são notificados cerca de 70.000 novos casos e cerca de 4.500 mortes por tuberculose.

scholarly journals Incidence and nature of human tuberculosis due to Mycobacterium africanum in South-East England: 1977–87

1989 ◽  
Vol 103 (1) ◽  
pp. 127-132 ◽  
Author(s):  
J. M. Grange ◽  
M. D. Yates
Keyword(s):  
Indian Subcontinent ◽  
Ethnic Origin ◽  
Tubercle Bacillus ◽  
Highly Pathogenic ◽  
Atypical Mycobacterium ◽  
European Origin ◽  
South East England ◽  
Urinary Tuberculosis ◽  
Mycobacterium Africanum ◽  
Clinical Awareness

SUMMARYA total of 210 new cases of tuberculosis due to Mycobacterium africanum were registered at the South-East Regional Centre for Tuberculosis Bacteriology, Dulwich, between 1977 and 1987 inclusive. This represented 1·25% of bacteriologically-confirmed cases of tuberculosis in South-East England, an incidence slightly higher than that of disease due to M. bovis. Two variants were identified: 150 strains were typed as African I (a type associated with East Africa) and 60 as African II (a type more prevalent in West Africa). Over half the patients infected with African I strains were of Indian subcontinent ethnic origin; patients of African ethnic origin predominated in the African II group while about a fifth of patients infected with either type were of European origin. The European patients with tuberculosis due to M. africanum were notably younger than those in the same region with disease due to other tubercle bacilli. The distribution of lesions due to M. africanum was similar to that due to other tubercle bacilli in the various ethnic groups, except that genito-urinary tuberculosis was uncommon. The importance of a clinical awareness that M. africanum is a highly pathogenic and transmissible tubercle bacillus rather than an opportunist or ‘atypical’ mycobacterium is stressed.

scholarly journals Revised Interpretation of the Hain Lifescience GenoType MTBC To Differentiate Mycobacterium canettii and Members of the Mycobacterium tuberculosis Complex

2019 ◽  
Vol 63 (6) ◽  
Author(s):  
Chloé Loiseau ◽  
Daniela Brites ◽  
Irmgard Moser ◽  
Francesc Coll ◽  
Christine Pourcel ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Mycobacterium Bovis ◽  
In Silico ◽  
Mycobacterium Tuberculosis Complex ◽  
Tuberculosis Complex ◽  
Content Type ◽  
Causative Agents ◽  
Mycobacterium Africanum

ABSTRACT Using 894 phylogenetically diverse genomes of the Mycobacterium tuberculosis complex (MTBC), we simulated in silico the ability of the Hain Lifescience GenoType MTBC assay to differentiate the causative agents of tuberculosis. Here, we propose a revised interpretation of this assay to reflect its strengths (e.g., it can distinguish some strains of Mycobacterium canettii and variants of Mycobacterium bovis that are not intrinsically resistant to pyrazinamide) and limitations (e.g., Mycobacterium orygis cannot be differentiated from Mycobacterium africanum).

scholarly journals Mycobacterial Etiology of Pulmonary Tuberculosis and Association with HIV Infection and Multidrug Resistance in Northern Nigeria

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Gambo Aliyu ◽  
Samer S. El-Kamary ◽  
Alash'le Abimiku ◽  
Nicholas Ezati ◽  
Iwakun Mosunmola ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Mycobacterium Tuberculosis ◽  
Multidrug Resistance ◽  
Pulmonary Tuberculosis ◽  
Hiv Infection ◽  
Mycobacterium Bovis ◽  
Northern Nigeria ◽  
Tb Treatment ◽  
Mycobacterium Africanum

Objective. Data on pulmonary tuberculosis (TB) caused byMycobacterium tuberculosis (MTB) complexin Nigeria are limited. We investigated species ofMTB complexin TB cases from northern Nigeria.Methods. New TB suspects were enrolled, screened for HIV and their sputum samples were cultured after routine microscopy. Genotypes MTBC and MTBDRpluswere used to characterize theMTB complexspecies and their resistance to isoniazid and rifampicin.Results. Of the 1,603 patients enrolled, 375 (23%) hadMTB complexinfection: 354 (94.4%) hadMycobacterium tuberculosis; 20 (5.3%) hadMycobacterium africanum; and one hadMycobacterium bovis(0.3%). Cases were more likely to be male (AOR = 1.87, 95% CI : 1.42–2.46;P≤0.001), young (AOR = 2.03, 95% CI : 1.56–2.65;P≤0.001) and have HIV (AOR = 1.43, 95% CI : 1.06–1.92;P=0.032). In 23 patients (6.1%), the mycobacterium was resistant to at least one drug, and these cases were more likely to have HIV and prior TB treatment (AOR = 3.62, 95% CI : 1.51–8.84;P=0.004; AOR : 4.43; 95% CI : 1.71–11.45P=0.002resp.), compared to cases without any resistance.Conclusion.Mycobacterium tuberculosisremained the predominant specie in TB in this setting followed byMycobacterium africanumwhileMycobacterium boviswas rare. The association of TB drug resistance with HIV has implications for TB treatment.

Sign in / Sign up

Export Citation Format

Share Document