Early disseminated Mycobacterium Abscessus Complex Infection in an Infant with Coexisting Cystic Fibrosis and Progressive Familial Intrahepatic Cholestasis

Mycobacterium abscessus complex (MABSC) is a rapidly growing mycobacterium and may rarely cause disseminated infections in immunocompromised patients. In patients with Cystic Fibrosis (CF), it peaks between the ages of 11 and 15 years. We present a 5 months old infant with coexisting CF and Progressive Familial Intrahepatic Cholestasis (PFIC) who had pulmonary and cutaneous dissemination of MABSC infection. The management of this disseminated infection in an infant with two coexisting chronic diseases was challenging which resulted in a rapid deterioration of lung disease and the progression of PFIC to liver cirrhosis with a fatal outcome. Keywords: Cystic Fibrosis; Atypical Mycobacterium; Mycobacterium abscessus complex; Progressive Familial Intrahepatic Cholestasis

Port site infection by Mycobacterium fortuitum after laparoscopic hysterectomy and its management– A case report

In the department of gynaecology vaginal hysterectomy and laparoscopic hysterectomy are popular methods of surgery. They involve less amount of blood loss, with short hospital stay. In recent times, laparoscopic hysterectomy is done commonly. Forty-two-year female was admitted in surgery ward, Tagore Medical College and Hospital, with pain in abdomen at the laparoscopic site and lower abdomen. Pus discharge through the port site, left loin for the last 3 months. The microbiological examination of the pus showed the presence of Mycobacterium fortuitum. After identification of atypical mycobacterium, the patient was administrated with amikacin injection for 3 months and clarithromycin and ofloxacin tablet for one year. Patient was discharged and was advised to come for periodical review.

Mycobacterium Kansasii Infection Overlying Tattoo Pigment in an Immunocompromised Patient

The incidence of atypical mycobacterial infections has steadily grown over the past decades, and it is well-known that the risk of progressive disease increases with immunodeficiency. While rare, tattoo pigment can serve as a nidus for atypical mycobacterium infection in immunocompromised individuals. Here, we present a case of a 41-year-old immunocompromised female who presented with verrucous plaques overlying long-standing tattoos in multiple locations. The patient’s lesions were biopsied and sent for board-range polymerase chain reaction revealing infection with Mycobacterium kansasii, a slow-growing atypical mycobacterium that rarely causes cutaneous disease without systemic symptoms. Early recognition and treatment of cutaneous M. kansasii is important to prevent progression of disease.

Atypical mycobacterium infection of sternoclavicular joint: A unique case

We report a rare case of atypical Mycobacterium intracellulare infection encountered in a left sternoclavicular joint of an immunocompetent patient. The 34-year-old female patient presented with a one-year history of left sternoclavicular joint pain and swelling. The patient had multiple radiological investigations, which were suspicious for an infective cause. The patient had a biopsy of the joint, which returned showing acid-fast bacilli. The patient consequently received a prolonged course of medical treatment for M. intracellulare.

PULMONARY TALCOSIS: A Foreign body granulomatous lung disease

Pulmonary Talcosis is a rare foreign body granulomatous disease that occurs as a result of exposure to talc either by inhalation of talc particles or via intravascular injection of talc containing medications. Pulmonary Talcosis is often misdiagnosed as pulmonary tuberculosis, atypical mycobacterium infection or sarcoidosis as many of their clinical and radiological findings overlap. We report a case of talcosis mimicking mycobacterial disease which was eventually diagnosed via lung biopsy. A detailed history and high index of suspicion is required for timely diagnosis and appropriate management.