scholarly journals Activity of rifapentine and its metabolite 25-O-desacetylrifapentine compared with rifampicin and rifabutin against Mycobacterium tuberculosis, Mycobacterium africanum, Mycobacterium bovis and M. bovis BCG

2000 ◽  
Vol 46 (4) ◽  
pp. 565-570 ◽  
Author(s):  
N. Rastogi ◽  
K. S. Goh ◽  
M. Berchel ◽  
A. Bryskier
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Mycobacterium Bovis ◽  
Mycobacterium Africanum

scholarly journals Revised Interpretation of the Hain Lifescience GenoType MTBC To Differentiate Mycobacterium canettii and Members of the Mycobacterium tuberculosis Complex

2019 ◽  
Vol 63 (6) ◽  
Author(s):  
Chloé Loiseau ◽  
Daniela Brites ◽  
Irmgard Moser ◽  
Francesc Coll ◽  
Christine Pourcel ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Mycobacterium Bovis ◽  
In Silico ◽  
Mycobacterium Tuberculosis Complex ◽  
Tuberculosis Complex ◽  
Content Type ◽  
Causative Agents ◽  
Mycobacterium Africanum

ABSTRACT Using 894 phylogenetically diverse genomes of the Mycobacterium tuberculosis complex (MTBC), we simulated in silico the ability of the Hain Lifescience GenoType MTBC assay to differentiate the causative agents of tuberculosis. Here, we propose a revised interpretation of this assay to reflect its strengths (e.g., it can distinguish some strains of Mycobacterium canettii and variants of Mycobacterium bovis that are not intrinsically resistant to pyrazinamide) and limitations (e.g., Mycobacterium orygis cannot be differentiated from Mycobacterium africanum).

scholarly journals Mycobacterial Etiology of Pulmonary Tuberculosis and Association with HIV Infection and Multidrug Resistance in Northern Nigeria

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Gambo Aliyu ◽  
Samer S. El-Kamary ◽  
Alash'le Abimiku ◽  
Nicholas Ezati ◽  
Iwakun Mosunmola ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Mycobacterium Tuberculosis ◽  
Multidrug Resistance ◽  
Pulmonary Tuberculosis ◽  
Hiv Infection ◽  
Mycobacterium Bovis ◽  
Northern Nigeria ◽  
Tb Treatment ◽  
Mycobacterium Africanum

Objective. Data on pulmonary tuberculosis (TB) caused byMycobacterium tuberculosis (MTB) complexin Nigeria are limited. We investigated species ofMTB complexin TB cases from northern Nigeria.Methods. New TB suspects were enrolled, screened for HIV and their sputum samples were cultured after routine microscopy. Genotypes MTBC and MTBDRpluswere used to characterize theMTB complexspecies and their resistance to isoniazid and rifampicin.Results. Of the 1,603 patients enrolled, 375 (23%) hadMTB complexinfection: 354 (94.4%) hadMycobacterium tuberculosis; 20 (5.3%) hadMycobacterium africanum; and one hadMycobacterium bovis(0.3%). Cases were more likely to be male (AOR = 1.87, 95% CI : 1.42–2.46;P≤0.001), young (AOR = 2.03, 95% CI : 1.56–2.65;P≤0.001) and have HIV (AOR = 1.43, 95% CI : 1.06–1.92;P=0.032). In 23 patients (6.1%), the mycobacterium was resistant to at least one drug, and these cases were more likely to have HIV and prior TB treatment (AOR = 3.62, 95% CI : 1.51–8.84;P=0.004; AOR : 4.43; 95% CI : 1.71–11.45P=0.002resp.), compared to cases without any resistance.Conclusion.Mycobacterium tuberculosisremained the predominant specie in TB in this setting followed byMycobacterium africanumwhileMycobacterium boviswas rare. The association of TB drug resistance with HIV has implications for TB treatment.

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