Il concetto di “diagnosi fuzzy”: una applicazione alla malattia di Anderson-Fabry* / The concept of “fuzzy diagnosis”: an application to the Anderson-Fabry disease

2018 ◽  
Vol 67 (5) ◽  
pp. 507-524
Author(s):  
Elena Mancini ◽  
Roberta Martina Zagarella
Keyword(s):  
Fabry Disease ◽  
Fuzzy Set ◽  
Individual Variability ◽  
Point Of View ◽  
Diagnostic Reliability ◽  
Real Objects ◽  
Diagnostic Hypothesis ◽  
Ethical Criteria ◽  
Fuzzy Diagnosis

Per garantire un’elevata affidabilità diagnostica, la classificazione tradizionale delle malattie si basa su due criteri fondamentali: la presenza di caratteristiche peculiari che identificano una malattia distinguendola dalle altre e l’individuazione delle cause o della correlazione multifattoriale. Questa concezione si basa su regole che rimandano ai principi della logica classica, la quale, tuttavia, non può considerarsi uno strumento adeguato in medicina. Essa potrebbe rivelarsi uno strumento utile di fronte a quelle manifestazioni della malattia “prototipiche”, ma non per molte patologie che si presentano come fenomeni complessi e incoerenti, ovvero caratterizzati, sul piano eziologico, da un insieme interrelato di possibili cause e fattori scatenanti e, sul piano clinico, da una elevata variabilità individuale. La diagnosi di tali malattie richiede una logica tramite la quale sia possibile categorizzare il mondo degli oggetti reali. L’articolo prende in esame la logica fuzzy come strumento per il ragionamento diagnostico, e in particolar modo i concetti di “fuzzy set” e “diagnosi fuzzy”, anche al fine di verificarne il possibile impiego nella diagnosi di una patologia rara ad eziologia complessa: la malattia di Anderson-Fabry. L’analisi svolta porta a soffermarsi sulla finalità pratica (e non conoscitiva) della diagnosi, che le conferisce una valenza etica. Muovendo da questa prospettiva, l’articolo propone, nell’ultima parte, alcuni criteri etici di orientamento nel complesso bilanciamento che il clinico effettua tra il rischio inerente alla formulazione di una ipotesi diagnostica di “tipo fuzzy” e i benefici per il paziente di una diagnosi precoce, soprattutto in considerazione della disponibilità di trattamenti farmacologici innovativi. ---------- To ensure high diagnostic reliability, the traditional classification of the diseases is based on two fundamental criteria: the presence of peculiar characteristics that identify a disease distinguishing it from the others; and the detection of causes or multifactorial correlation. This idea is based on rules that refer to the principles of classical logic, which however cannot be considered an appropriate tool in medicine. It may prove to be a useful tool in case of “prototypical” manifestations of a disease, but not for a lot of pathologies that appear as complex and inconsistent cases, or characterized (on the etiological plane) by an interrelation between possible causes and trigger factors, and (on the clinical plane) by an high individual variability. The diagnosis of such diseases requires a logic through which it is possible to categorize the world of real objects. The article examines the fuzzy logic as a tool for the diagnostic reasoning, and particularly the “fuzzy set” and “fuzzy diagnosis” concepts, in order to verify its possible use in the diagnosis of a rare disease with complex etiology: the Anderson-Fabry disease. Our analysis underlines the practical (and not theoretical) purpose of the diagnosis, which gives it an ethical value. From this point of view, the article suggests, in the last part, some ethical criteria in the balance carried out by the clinician between the risk concerning the formulation of a “fuzzy” diagnostic hypothesis and the advantages of an early diagnosis for the patients, especially considering the availability of innovative pharmacological treatments.

RHYNCHOLITES AND THE PROBLEM OF NARROW AND BROAD CONCEPTION OF TAXONS

2018 ◽  
pp. 12-17 ◽  
Author(s):  
I. R. Khuzina ◽  
V. N. Komarov
Keyword(s):  
Sexual Dimorphism ◽  
Morphological Characteristics ◽  
Mass Scale ◽  
Individual Variability ◽  
Point Of View ◽  
The Other ◽  
New Taxon ◽  
Artificial System ◽  
Broad Understanding

The paper considers a point of view, based on the conception of the broad understanding of taxons. According to this point of view, rhyncholites of the subgenus Dentatobeccus and Microbeccus are accepted to be synonymous with the genus Rhynchoteuthis, and subgenus Romanovichella is considered to be synonymous with the genus Palaeoteuthis. The criteria, exercising influence on the different approaches to the classification of rhyncholites, have been analyzed (such as age and individual variability, sexual dimorphism, pathological and teratological features, degree of disintegration of material), underestimation of which can lead to inaccuracy. Divestment of the subgenuses Dentatobeccus, Microbeccus and Romanovichella, possessing very bright morphological characteristics, to have an independent status and denomination to their synonyms, has been noted to be unjustified. An artificial system (any suggested variant) with all its minuses is a single probable system for rhyncholites. The main criteria, minimizing its negative sides and proving the separation of the new taxon, is an available mass-scale material. The narrow understanding of the genus, used in sensible limits, has been underlined to simplify the problem of the passing the view about the genus to the other investigators and recognition of rhyncholites for the practical tasks.

LEGAL, MORAL AND ETHICAL SIDE OF THE OFFENSE, DISCREDITING HONOR EMPLOYEE THE PENAL SYSTEM

2020 ◽  
Vol 10 (2) ◽  
pp. 213-218
Author(s):  
OKSANA KOCHKINA ◽  
◽  
OLGA MARCHUK ◽  
Keyword(s):  
Point Of View ◽  
Professional Activity ◽  
Penal System ◽  
Moral Norms ◽  
Ethical Aspects ◽  
Self Assessment ◽  
Personal Qualities ◽  
Executive System ◽  
Correction System

The article examines the legal and moral and ethical aspects of a misdemeanor that discredits the honor of an employee of the criminal Executive system. The considered reason for dismissal has the main feature associated with the integration of legal and moral norms, which often raises a lot of questions about the attribution of a particular offense to this basis. Using the analysis of normative legal acts, the authors attempt to identify the signs that contribute to the separation of the studied grounds for dismissal from all their diversity. The classification of offenses that discredit the honor of an employee of the criminal Executive system is presented, which allows to systematize and organize the knowledge obtained about the considered grounds for dismissal. The analysis of a misdemeanor that defames the honor of an employee of the penal system from a moral and ethical position gives an understanding, first of all, that it does not have a clear regulation from the point of view of the law, but the consequences of committing such a misdemeanor are clearly legal. The concepts of “honor” and “dignity” are considered as ethical categories and are analyzed as personal qualities that are manifested in an employee of the penal correction system during the period of service. These categories in the behavior of a person or employee are manifested both externally (assessment from the outside) and internally (self-assessment). The article describes the value orientation of an employee of the criminal Executive system to ethical standards in professional activity, which is an integral part of the moral and ethical side of a misdemeanor that discredits the honor of an employee.

REFLECTION OF THE CURRENT STATE OF PUBLICISTIC JOURNALISM GENRES IN THE SLOVAK MEDIA ENVIRONMENT

2020 ◽  
Author(s):  
Zuzana Kvetanová
Keyword(s):  
Discourse Analysis ◽  
Point Of View ◽  
Media Theory ◽  
Logical Analysis ◽  
Periodical Press ◽  
Media Environment ◽  
Current State ◽  
Journalistic Practice ◽  
Opinion Journalism

The submitted study addresses the topic of the current state of the opinion journalism and its genres in the Slovak periodical press. The author draws attention to the question of classification of the opinion journalism of a rational and emotional type from the genre categorization point of view and, simultaneously, reflects on its application in the present journalistic practice. This brings a certain rate of confrontation between the defined theoretical premises and their subsequent practical (non-)implementation. The main objective of the study is to clarify the presence of genres of analytical and literary opinion journalism stated by media theory in the environment of the Slovak periodicals. Presentation of the basic terminological axis and the related explication of journalism genres included in the opinion journalism constitute the secondary objectives of the paper. For the purposes of achieving the set objectives, the author uses methods of logical analysis of text in combination with discourse analysis. Similarly, she predicts the evident presence of the phenomenon of hybridization in the Slovak journalistic practice.

Reductionism and holism in the philosophy of medicine

2020 ◽  
pp. 66-74
Author(s):  
E. Zakablukovskiy
Keyword(s):  
Philosophy Of Medicine ◽  
Point Of View ◽  
Social Model ◽  
Macro Level ◽  
New Classification

The article highlights certain aspects of the discussion on the topic of reductionism vs. holism in the philosophy of medicine. Classic radical reductionism is defeated by the concept of emergence. The s.c. bio-medical point of view on a malady, despite its relevance and clear benefit, is not recognized as universal as its adherents may claim, and it yields to an integral psycho-bio-social model. The author introduces a new classification of holism (vitalistic, social and individualistic) and makes appropriate recommendations to clinicians. It is social holism at the macro level that has proven effective in combating the spread of COVID-19.

To the Question of the Classification Patterns of Social Stratification in the Countries of the World (Brief Overview of Some Concepts and Author’s Comment)

2020 ◽  
pp. 65-75
Author(s):  
S. N. Smirnov
Keyword(s):  
Social Sciences ◽  
Social Stratification ◽  
Legal Status ◽  
Scientific Literature ◽  
Point Of View ◽  
The World

The author considers the problems of typification of society. Some concepts of typification of social stratification models in different countries formulated and justified in historical and legal, historical, sociological, and economic scientific literature are reviewed. The circumstances that make it difficult to formulate universal concepts designed for application in the complex of social Sciences are identified. These circumstances include insufficient consideration of legal factors, including the position of the legislator, the specifics of the corporate legal status, and the characteristics of the mechanism for changing individual legal status. The author offers a variant of classification of society types from the point of view of legal registration of their structure. The possibility of distinguishing types such as consolidated companies and segmented companies is justified.

scholarly journals Phylogenetic relationships among accessions in Citrus and related genera based on the insertion polymorphism of the CIRE1 retrotransposon

2020 ◽  
Vol 5 (1) ◽  
pp. 243-251
Author(s):  
Akira Horibata ◽  
Tsuneo Kato
Keyword(s):  
Phylogenetic Relationships ◽  
Sweet Orange ◽  
Point Of View ◽  
Insertion Polymorphism ◽  
Navel Orange ◽  
Citrus Germplasm ◽  
Outgroup Species ◽  
Blood Orange

AbstractA total of 145 accessions of the genus Citrus and related genera, maintained in the Conservation Garden for Citrus Germplasm at the Experimental Farm of Kindai University, Yuasa, Wakayama, Japan, were examined for their phylogenetic relationships. The present classification was conducted using an inter-retrotransposon amplified polymorphism (IRAP) method based on the insertion polymorphism of a retrotransposon, CIRE1, identified in C. sinensis. The objective of this study was to evaluate the applicability of the IRAP method for citrus classification. The constructed dendrogram showed that the 145 accessions and two outgroup species were successfully classified into five major clades. A large number of C. sinensis accessions were divided into three traditional groups, navel orange, sweet orange, and blood orange, almost corresponding to the sub-clades in the dendrogram. Several other accessions belonging to the same species, and also many hybrid cultivars from crossbreeding, were localized into the respective sub-clades or near positions in the dendrogram. Several unclassified accessions could also be located in the dendrogram, suggesting novel relationships with other accessions. It was concluded that the IRAP method based on CIRE1 insertion polymorphism was suitable for the classification of citrus from a molecular point of view.

A GALLERY OF CHUA ATTRACTORS PART VI

2007 ◽  
Vol 17 (06) ◽  
pp. 1801-1910 ◽  
Author(s):  
ELEONORA BILOTTA ◽  
GIANPIERO DI BLASI ◽  
FAUSTO STRANGES ◽  
PIETRO PANTANO
Keyword(s):  
Phase Space ◽  
Spatial Organization ◽  
Fractal Dimensions ◽  
Point Of View ◽  
Experimental Investigations ◽  
Technical Data ◽  
Future Studies ◽  
Small Set ◽  
Methodological Approaches

In this article, we conclude our series of papers on the analysis and visualization of Chua attractors and their generalizations. We present a gallery of 144 n-scroll, 15 hyperchaotic and 37 synchronized systems. Along with time series and FFT we provide 3D visualizations; for some attractors we also supply Lyapunov coefficients and fractal dimensions. The goal in constructing our Gallery has been to make the general public aware of the enormous variety of chaotic phenomena and to change the widespread impression that they are isolated rarities. The Gallery provides a valuable collection of images and technical data which can be used to analyze these phenomena and to reproduce them in future studies. From a scientific point of view, we have tried to identify new methodological approaches to the study of chaos, opening nontraditional perspectives on the complexity of this domain. In our papers, we have discussed a broad range of topics, ranging from techniques for visualizing Chua attractors to computational methods allowing us to make a statistical classification of attractors' positions in phase space and to describe the evolutionary processes through which their shapes change over time. We see these processes as analogous to population dynamics in artificial environments. Within these environments, we use experimental methods to identify the models which guide morphogenetic change and which organize genetic landscapes in parameter space. This paper is organized as follows. First, we provide formal descriptions of the attractors generated by n-scroll, hyperchaotic and synchronized systems. The next section describes a Gallery of Chua attractors, generated by gradually varying the parameters and analyzing the resulting bifurcation maps. We then describe software tools allowing us to perform statistical analyses on selected sets of attractors, to visualize them, to explore their organization in phase space, and to conduct experimental investigations of the morphogenetic processes through which a small set of base attractors can generate a broad range of different forms. In the last section, we describe the creation of a Virtual 3D Gallery displaying some of the attractors we have presented in our six papers. The attractors are organized by theme, as they might be in a museum. The environment allows users to explore the attractors, interact with shapes, listen to music and sounds generated by the attractors, change their spatial organization, and create new shapes. To complete the paper — and the series — we propose a number of general conclusions.

scholarly journals Events, Time and the Simple Form

2009 ◽  
Vol 17 (1) ◽  
pp. 85-105 ◽  
Author(s):  
Walter H. Hirtle
Keyword(s):  
Simple Form ◽  
Point Of View ◽  
Event Time ◽  
The Difference ◽  
Time Required ◽  
English Verb

Abstract This is an attempt to discern more clearly the underlying or POTENTIAL meaning of the simple form of the English verb, described in Hirtle 1967 as 'perfective'. Vendler's widely accepted classification of events into ACCOMPLISHMENTS, ACHIEVEMENTS, ACTIVITIES, and STATES is examined from the point of view of the time necessarily contained between the beginning and end of any event, i.e. EVENT TIME as represented by the simple form. This examination justifies the well known dynamic/stative dichotomy by showing that event time is evoked in two different ways, that, in fact, the simple form has two ACTUAL significates. Further reflection on the difference between the two types thus expressed—developmental or action-like events and non-developmental or state-like events—leads to the conclusion that the simple form provides a representation of the time required to situate all the impressions involved in the notional or lexical import of the verb.

Perbandingan Optimasi Feature Selection pada Naïve Bayes untuk Klasifikasi Kepuasan Airline Passenger

2021 ◽  
Vol 5 (3) ◽  
pp. 527-533
Author(s):  
Yoga Religia ◽  
Amali Amali
Keyword(s):  
Feature Selection ◽  
Customer Satisfaction ◽  
Naive Bayes ◽  
Naïve Bayes ◽  
Point Of View ◽  
Classification Model ◽  
Passenger Satisfaction ◽  
Airline Passenger ◽  
Bayes Algorithm

The quality of an airline's services cannot be measured from the company's point of view, but must be seen from the point of view of customer satisfaction. Data mining techniques make it possible to predict airline customer satisfaction with a classification model. The Naïve Bayes algorithm has demonstrated outstanding classification accuracy, but currently independent assumptions are rarely discussed. Some literature suggests the use of attribute weighting to reduce independent assumptions, which can be done using particle swarm optimization (PSO) and genetic algorithm (GA) through feature selection. This study conducted a comparison of PSO and GA optimization on Naïve Bayes for the classification of Airline Passenger Satisfaction data taken from www.kaggle.com. After testing, the best performance is obtained from the model formed, namely the classification of Airline Passenger Satisfaction data using the Naïve Bayes algorithm with PSO optimization, where the accuracy value is 86.13%, the precision value is 87.90%, the recall value is 87.29%, and the value is AUC of 0.923.

Recognising Psychiatric Symptoms

1993 ◽  
Vol 163 (3) ◽  
pp. 308-314 ◽  
Author(s):  
G. E. Berrios ◽  
E. Y. H. Chen
Keyword(s):  
Psychiatric Symptoms ◽  
Cognitive Styles ◽  
Point Of View ◽  
Stage Model ◽  
Diagnostic Systems ◽  
Contextual Cues ◽  
Additional Information ◽  
Neural Network Simulation ◽  
Symptom Recognition ◽  
Diagnostic Hypothesis

Current overemphasis on nosological diagnosis has led to a neglect of the process of symptom recognition. There is evidence, however, that the perception of the symptom alone does not guarantee symptom ascertainment since a decision-making component is also involved. To achieve the latter, additional information must be provided by the contextual cues implicit in the ongoing diagnostic hypothesis. Current diagnostic systems, however, still assume a two-stage model according to which symptom and disease recognition are independent cognitive events. This paper suggests that this model is inadequate and that descriptive psychopathology is nottransparent. It then describes a neural network simulation to make various aspects of the problem explicit. This takes into account the multidimensional and probabilistic aspects of symptom recognition and is, from this point of view, superior to traditional algorithmic models. It also has the capacity to represent the different cognitive styles involved in symptom recognition.

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