scholarly journals Advances in the Multi-Orthogonal Folding of Single Polymer Chains into Single-Chain Nanoparticles

Polymers ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 293
Author(s):  
Agustín Blazquez-Martín ◽  
Ester Verde-Sesto ◽  
Angel J. Moreno ◽  
Arantxa Arbe ◽  
Juan Colmenero ◽  
...  
Keyword(s):  
Computer Simulations ◽  
Chemical Species ◽  
Synthetic Polymers ◽  
Review Article ◽  
Polymer Chains ◽  
Single Chain ◽  
High Dilution ◽  
Covalent Bonds ◽  
Covalent Interactions ◽  
Individual Polymer

The folding of certain proteins (e.g., enzymes) into perfectly defined 3D conformations via multi-orthogonal interactions is critical to their function. Concerning synthetic polymers chains, the “folding” of individual polymer chains at high dilution via intra-chain interactions leads to so-called single-chain nanoparticles (SCNPs). This review article describes the advances carried out in recent years in the folding of single polymer chains into discrete SCNPs via multi-orthogonal interactions using different reactive chemical species where intra-chain bonding only occurs between groups of the same species. First, we summarize results from computer simulations of multi-orthogonally folded SCNPs. Next, we comprehensively review multi-orthogonally folded SCNPs synthesized via either non-covalent bonds or covalent interactions. Finally, we conclude by summarizing recent research about multi-orthogonally folded SCNPs prepared through both reversible (dynamic) and permanent bonds.

scholarly journals Advances in the Multi-Orthogonal Folding of Single Polymer Chains into Single-Chain Nanoparticles

2020 ◽  
Author(s):  
Agustín Blazquez-Martín ◽  
Ester Verde-Sesto ◽  
Angel J. Moreno ◽  
Arantxa Arbe ◽  
Juan Colmenero ◽  
...  
Keyword(s):  
Computer Simulations ◽  
Chemical Species ◽  
Synthetic Polymers ◽  
Review Article ◽  
Polymer Chains ◽  
Single Chain ◽  
High Dilution ◽  
Covalent Bonds ◽  
Covalent Interactions ◽  
Individual Polymer

The folding of certain proteins (e.g., enzymes) into perfectly defined 3D conformations via multi-orthogonal interactions is critical to their function. Concerning synthetic polymers chains, the “folding” of individual polymer chains at high dilution via intra-chain interactions leads to so-called single-chain nanoparticles (SCNPs). This review article describes the advances carried out in recent years in the folding of single polymer chains into discrete SCNPs via multi-orthogonal interactions using different reactive chemical species where intra-chain bonding only occurs between groups of the same species. First, we summarize results from computer simulations of multi-orthogonally folded SCNPs. Next, we comprehensively review multi-orthogonally folded SCNPs synthesized via either non-covalent bonds or covalent interactions. Finally, we conclude by summarizing recent research about multi-orthogonally folded SCNPs prepared through both reversible (dynamic) and permanent bonds.

scholarly journals Advances in Single-Chain Nanoparticles for Catalysis Applications

2017 ◽  
Author(s):  
Jon Rubio-Cervilla ◽  
Edurne González ◽  
José A. Pomposo
Keyword(s):  
Chemical Compounds ◽  
Inorganic Nanoparticles ◽  
Polymer Chains ◽  
Carbon Nanodots ◽  
Aqueous Environment ◽  
High Catalytic Activity ◽  
Artificial Enzyme ◽  
Single Chain ◽  
Capture And Release ◽  
Individual Polymer

Enzymes are the most efficient catalysts known working in an aqueous environment near room temperature. The folding of individual polymer chains to functional single-chain nanoparticles (SCNPs) offers many opportunities for the development of artificial enzyme-mimic catalysts showing both high catalytic activity and specificity. In this review, we highlight recent results obtained in the use of SCNPs as bioinspired, highly-efficient nanoreactors (3–30 nm) for the synthesis of a variety of nanomaterials (inorganic nanoparticles, quantum dots, carbon nanodots), polymers and chemical compounds, as well as nanocontainers for CO2 capture and release.

scholarly journals Multi-orthogonal folding of single polymer chains into soft nanoparticles

Soft Matter ◽  
2014 ◽  
Vol 10 (27) ◽  
pp. 4813-4821 ◽  
Author(s):  
Federica Lo Verso ◽  
José A. Pomposo ◽  
J. Colmenero ◽  
Angel J. Moreno
Keyword(s):  
Chemical Species ◽  
Polymer Chains ◽  
Single Chain ◽  
Chain Polymer ◽  
Polymer Precursors ◽  
The Cross ◽  
Dark Blue ◽  
Soft Nanoparticles

Typical topologies of cross-linked nanoparticles are obtained by orthogonal folding of single chain polymer precursors. The number of different chemical species of the cross-linkers is 4 (top) and 6 (bottom). Dark blue beads correspond to inactive monomers. Beads of other colours correspond to the reactive linkers (a different colour for each chemical species, note the pairs of bonded linkers).

scholarly journals Light-fueled dynamic covalent crosslinking of single polymer chains in non-equilibrium states

2021 ◽  
Author(s):  
Daniel Kodura ◽  
Hannes A. Houck ◽  
Fabian R. Bloesser ◽  
Anja S. Goldmann ◽  
Filip E. Du Prez ◽  
...  
Keyword(s):  
Green Light ◽  
Synthetic Polymers ◽  
Equilibrium States ◽  
Polymer Chains ◽  
Single Chain ◽  
Covalent Crosslinking ◽  
Non Equilibrium

Synthetic polymers consume green light as fuel for intramolecular crosslinking, yielding non-equilibrium single chain nanoparticles that can be light-stabilised, kinetically and chemically trapped, or else unfold in the absence of light fuel.

SuFExable Polymers with Helical Structures Derived from Thionyl Tetrafluoride (SOF4)

2019 ◽  
Author(s):  
Suhua Li ◽  
Gencheng Li ◽  
Bing Gao ◽  
Sidharam P. Pujari ◽  
Xiaoyan Chen ◽  
...  
Keyword(s):  
Functional Polymers ◽  
Polymer Chains ◽  
New Materials ◽  
Helical Structures ◽  
Polymer Backbone ◽  
Silyl Ethers ◽  
Helical Polymer ◽  
Key Characteristics ◽  
Post Modification ◽  
Individual Polymer

The first SuFEx click chemistry synthesis of SOF<sub>4</sub>-derived copolymers based upon the polymerization of bis(iminosulfur oxydifluorides) and bis(aryl silyl ethers) is described. This novel class of SuFEx polymer presents two key characteristics: First, the newly created [-N=S(=O)F-O-] polymer backbone linkages are themselves SuFExable and primed to undergo further high-yielding and precise SuFEx-based post-modification with phenols or amines to yield branched functional polymers. Second, studies of individual polymer chains of several of these new materials indicate the presence of helical polymer structures, which itself suggests a preferential approach of new monomers onto the growing polymer chain upon the formation of the stereogenic linking moiety.

Chemiluminescent self-reported unfolding of single-chain nanoparticles

2021 ◽  
Author(s):  
Fabian R. Bloesser ◽  
Sarah L. Walden ◽  
Ishrath M. Irshadeen ◽  
Lewis C. Chambers ◽  
Christopher Barner-Kowollik
Keyword(s):  
Polymer Chains ◽  
Linear Polymer ◽  
Single Chain

We demonstrate the light-induced, crosslinker mediated collapse of linear polymer chains into single-chain nanoparticles (SCNPs) capable of self-reporting their unfolding.

scholarly journals On the Proton-Bound Noble Gas Dimers (Ng-H-Ng)+ and (Ng-H-Ng')+ (Ng, Ng'= He-Xe): Relationships betweenStructure, Stability, and Bonding Character

Molecules ◽  
2021 ◽  
Vol 26 (5) ◽  
pp. 1305
Author(s):  
Stefano Borocci ◽  
Felice Grandinetti ◽  
Nico Sanna
Keyword(s):  
Theoretical Calculations ◽  
Noble Gas ◽  
Structure Stability ◽  
Covalent Bonds ◽  
Dissociation Energies ◽  
Non Covalent Interactions ◽  
The Difference ◽  
Noble Gas Dimers ◽  
Covalent Interactions ◽  
Cluster Level

The structure, stability, and bonding character of fifteen (Ng-H-Ng)+ and (Ng-H-Ng')+ (Ng, Ng' = He-Xe) compounds were explored by theoretical calculations performed at the coupled cluster level of theory. The nature of the stabilizing interactions was, in particular, assayed using a method recently proposed by the authors to classify the chemical bonds involving the noble-gas atoms. The bond distances and dissociation energies of the investigated ions fall in rather large intervals, and follow regular periodic trends, clearly referable to the difference between the proton affinity (PA) of the various Ng and Ng'. These variations are nicely correlated with the bonding situation of the (Ng-H-Ng)+ and (Ng-H-Ng')+. The Ng-H and Ng'-H contacts range, in fact, between strong covalent bonds to weak, non-covalent interactions, and their regular variability clearly illustrates the peculiar capability of the noble gases to undergo interactions covering the entire spectrum of the chemical bond.

Delineating synchronized control of dynamic covalent and non-covalent interactions for polymer chain collapse towards cargo localization and delivery

2021 ◽  
Author(s):  
Jojo P Joseph ◽  
Chirag Miglani ◽  
Aashish Bhatt ◽  
Debes Ray ◽  
Ashmeet Singh ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polymer Chain ◽  
Structural Control ◽  
Synthetic Polymers ◽  
Folding Process ◽  
Non Covalent Interactions ◽  
Covalent Interactions ◽  
Synchronized Control

Chain collapse in synthetic polymers is an excellent approach to mimick natural self-folding process that imparts structural control leading to attractive compartmental applications e.g. drug delivery. In this regard, water...

scholarly journals Enzymatic and Chemical Cross-Linking of Bacterial Cellulose/Fish Collagen Composites—A Comparative Study

2021 ◽  
Vol 22 (7) ◽  
pp. 3346
Author(s):  
Agata Sommer ◽  
Paulina Dederko-Kantowicz ◽  
Hanna Staroszczyk ◽  
Sławomir Sommer ◽  
Marek Michalec
Keyword(s):  
Thermal Stability ◽  
Bacterial Cellulose ◽  
Secondary Alcohol ◽  
Water Vapor Permeability ◽  
Polymer Chains ◽  
Cross Linking ◽  
Vapor Permeability ◽  
Covalent Bonds ◽  
Fish Collagen ◽  
Chemical Cross Linking

This article compares the properties of bacterial cellulose/fish collagen composites (BC/Col) after enzymatic and chemical cross-linking. In our methodology, two transglutaminases are used for enzymatic cross-linking—one recommended for the meat and the other proposed for the fish industry—and pre-oxidated BC (oxBC) is used for chemical cross-linking. The structure of the obtained composites is characterized by scanning electron microscopy, thermogravimetric analysis, X-ray diffraction, and Fourier transform infrared spectroscopy, and their functional properties by mechanical and water barrier tests. While polymer chains in uncross-linked BC/Col are intertwined by H-bonds, new covalent bonds in enzymatically cross-linked ones are formed—resulting in increased thermal stability and crystallinity of the material. The C2–C3 bonds cleavage in D-glucose units, due to BC oxidation, cause secondary alcohol groups to vanish in favor of the carbonyl groups’ formation, thus reducing the number of H-bonded OHs. Thermal stability and crystallinity of oxBC/Col remain lower than those of BC/Col. The BC/Col formation did not affect tensile strength and water vapor permeability of BC, but enzymatic cross-linking with TGGS improved them significantly.

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