Chemiluminescent self-reported unfolding of single-chain nanoparticles

2021 ◽  
Author(s):  
Fabian R. Bloesser ◽  
Sarah L. Walden ◽  
Ishrath M. Irshadeen ◽  
Lewis C. Chambers ◽  
Christopher Barner-Kowollik
Keyword(s):  
Polymer Chains ◽  
Linear Polymer ◽  
Single Chain

We demonstrate the light-induced, crosslinker mediated collapse of linear polymer chains into single-chain nanoparticles (SCNPs) capable of self-reporting their unfolding.

pH-responsive single-chain polymer nanoparticles utilising dynamic covalent enamine bonds

2014 ◽  
Vol 50 (15) ◽  
pp. 1871-1874 ◽  
Author(s):  
Ana Sanchez-Sanchez ◽  
David A. Fulton ◽  
José A. Pomposo
Keyword(s):  
Polymer Chains ◽  
Polymer Nanoparticles ◽  
Linear Polymer ◽  
Ph Responsive ◽  
Single Chain ◽  
Chain Polymer ◽  
Cross Links

Dynamic covalent enamine cross-links facilitate the reversible structural interconversion of dynamic single-chain polymer nanoparticles into linear polymer chains using pH as a trigger.

scholarly journals Advances in the Multi-Orthogonal Folding of Single Polymer Chains into Single-Chain Nanoparticles

Polymers ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 293
Author(s):  
Agustín Blazquez-Martín ◽  
Ester Verde-Sesto ◽  
Angel J. Moreno ◽  
Arantxa Arbe ◽  
Juan Colmenero ◽  
...  
Keyword(s):  
Computer Simulations ◽  
Chemical Species ◽  
Synthetic Polymers ◽  
Review Article ◽  
Polymer Chains ◽  
Single Chain ◽  
High Dilution ◽  
Covalent Bonds ◽  
Covalent Interactions ◽  
Individual Polymer

The folding of certain proteins (e.g., enzymes) into perfectly defined 3D conformations via multi-orthogonal interactions is critical to their function. Concerning synthetic polymers chains, the “folding” of individual polymer chains at high dilution via intra-chain interactions leads to so-called single-chain nanoparticles (SCNPs). This review article describes the advances carried out in recent years in the folding of single polymer chains into discrete SCNPs via multi-orthogonal interactions using different reactive chemical species where intra-chain bonding only occurs between groups of the same species. First, we summarize results from computer simulations of multi-orthogonally folded SCNPs. Next, we comprehensively review multi-orthogonally folded SCNPs synthesized via either non-covalent bonds or covalent interactions. Finally, we conclude by summarizing recent research about multi-orthogonally folded SCNPs prepared through both reversible (dynamic) and permanent bonds.

Pulses of Fast Electrons as a Tool To Synthesize Poly(acrylic acid) Nanogels. Intramolecular Cross-Linking of Linear Polymer Chains in Additive-Free Aqueous Solution

2003 ◽  
Vol 36 (7) ◽  
pp. 2484-2492 ◽  
Author(s):  
Slawomir Kadlubowski ◽  
Jaroslaw Grobelny ◽  
Wielislaw Olejniczak ◽  
Michal Cichomski ◽  
Piotr Ulanski
Keyword(s):  
Aqueous Solution ◽  
Acrylic Acid ◽  
Polymer Chains ◽  
Linear Polymer ◽  
Cross Linking ◽  
Fast Electrons ◽  
Poly Acrylic Acid

Star/Linear Polymer Topology Transformation Facilitated by Mechanical Linking of Polymer Chains

2015 ◽  
Vol 54 (23) ◽  
pp. 6770-6774 ◽  
Author(s):  
Daisuke Aoki ◽  
Satoshi Uchida ◽  
Toshikazu Takata
Keyword(s):  
Polymer Chains ◽  
Linear Polymer ◽  
Polymer Topology

Structure of Polymer Chains Confined in Vycor

1996 ◽  
Vol 464 ◽  
Author(s):  
Jyotsana Lal ◽  
Sunil K. Sinha ◽  
Loic Auvray
Keyword(s):  
Porous Medium ◽  
Porous Media ◽  
Form Factor ◽  
Small Angle Neutron Scattering ◽  
Pore Diameter ◽  
Polymer Chains ◽  
Bulk Solution ◽  
Radius Of Gyration ◽  
Single Chain ◽  
Molecular Weights

ABSTRACTWe observe by Small Angle Neutron Scattering (SANS) the structure of polystyrene chains in semi-dilute solutions confined in model porous medium, Vycor. The size of the free polymer chains in solution is always larger than the pore diameter, 70 Å. The use of a suitable mixture of hydrogenated and deuterated solvents and polymers enables us to directly measure the form factor of one single chain among the others. The penetration of the chain in the porous media is almost complete for the concentration (Φ = 20%) and the range of molecular weights (35000 <M< 800000) used. The measured radius of gyration of confined chains is always smaller than the radius of gyration of free chains in the equivalent bulk solution.

A brief user's guide to single-chain nanoparticles

2015 ◽  
Vol 6 (2) ◽  
pp. 181-197 ◽  
Author(s):  
Christopher K. Lyon ◽  
Alka Prasher ◽  
Ashley M. Hanlon ◽  
Bryan T. Tuten ◽  
Christian A. Tooley ◽  
...  
Keyword(s):  
Polymer Chains ◽  
Single Chain ◽  
Potential Applications

In this review we outline the various methods that have been explored to synthesize architecturally defined nanoparticles from discrete polymer chains, summarize the methods of characterization that are required to prove their formation and probe their morphology, and introduce a number of potential applications.

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