scholarly journals Multi-orthogonal folding of single polymer chains into soft nanoparticles

Soft Matter ◽  
2014 ◽  
Vol 10 (27) ◽  
pp. 4813-4821 ◽  
Author(s):  
Federica Lo Verso ◽  
José A. Pomposo ◽  
J. Colmenero ◽  
Angel J. Moreno
Keyword(s):  
Chemical Species ◽  
Polymer Chains ◽  
Single Chain ◽  
Chain Polymer ◽  
Polymer Precursors ◽  
The Cross ◽  
Dark Blue ◽  
Soft Nanoparticles

Typical topologies of cross-linked nanoparticles are obtained by orthogonal folding of single chain polymer precursors. The number of different chemical species of the cross-linkers is 4 (top) and 6 (bottom). Dark blue beads correspond to inactive monomers. Beads of other colours correspond to the reactive linkers (a different colour for each chemical species, note the pairs of bonded linkers).

scholarly journals Advances in the Multi-Orthogonal Folding of Single Polymer Chains into Single-Chain Nanoparticles

Polymers ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 293
Author(s):  
Agustín Blazquez-Martín ◽  
Ester Verde-Sesto ◽  
Angel J. Moreno ◽  
Arantxa Arbe ◽  
Juan Colmenero ◽  
...  
Keyword(s):  
Computer Simulations ◽  
Chemical Species ◽  
Synthetic Polymers ◽  
Review Article ◽  
Polymer Chains ◽  
Single Chain ◽  
High Dilution ◽  
Covalent Bonds ◽  
Covalent Interactions ◽  
Individual Polymer

The folding of certain proteins (e.g., enzymes) into perfectly defined 3D conformations via multi-orthogonal interactions is critical to their function. Concerning synthetic polymers chains, the “folding” of individual polymer chains at high dilution via intra-chain interactions leads to so-called single-chain nanoparticles (SCNPs). This review article describes the advances carried out in recent years in the folding of single polymer chains into discrete SCNPs via multi-orthogonal interactions using different reactive chemical species where intra-chain bonding only occurs between groups of the same species. First, we summarize results from computer simulations of multi-orthogonally folded SCNPs. Next, we comprehensively review multi-orthogonally folded SCNPs synthesized via either non-covalent bonds or covalent interactions. Finally, we conclude by summarizing recent research about multi-orthogonally folded SCNPs prepared through both reversible (dynamic) and permanent bonds.

scholarly journals Advances in the Multi-Orthogonal Folding of Single Polymer Chains into Single-Chain Nanoparticles

2020 ◽  
Author(s):  
Agustín Blazquez-Martín ◽  
Ester Verde-Sesto ◽  
Angel J. Moreno ◽  
Arantxa Arbe ◽  
Juan Colmenero ◽  
...  
Keyword(s):  
Computer Simulations ◽  
Chemical Species ◽  
Synthetic Polymers ◽  
Review Article ◽  
Polymer Chains ◽  
Single Chain ◽  
High Dilution ◽  
Covalent Bonds ◽  
Covalent Interactions ◽  
Individual Polymer

The folding of certain proteins (e.g., enzymes) into perfectly defined 3D conformations via multi-orthogonal interactions is critical to their function. Concerning synthetic polymers chains, the “folding” of individual polymer chains at high dilution via intra-chain interactions leads to so-called single-chain nanoparticles (SCNPs). This review article describes the advances carried out in recent years in the folding of single polymer chains into discrete SCNPs via multi-orthogonal interactions using different reactive chemical species where intra-chain bonding only occurs between groups of the same species. First, we summarize results from computer simulations of multi-orthogonally folded SCNPs. Next, we comprehensively review multi-orthogonally folded SCNPs synthesized via either non-covalent bonds or covalent interactions. Finally, we conclude by summarizing recent research about multi-orthogonally folded SCNPs prepared through both reversible (dynamic) and permanent bonds.

pH-responsive single-chain polymer nanoparticles utilising dynamic covalent enamine bonds

2014 ◽  
Vol 50 (15) ◽  
pp. 1871-1874 ◽  
Author(s):  
Ana Sanchez-Sanchez ◽  
David A. Fulton ◽  
José A. Pomposo
Keyword(s):  
Polymer Chains ◽  
Polymer Nanoparticles ◽  
Linear Polymer ◽  
Ph Responsive ◽  
Single Chain ◽  
Chain Polymer ◽  
Cross Links

Dynamic covalent enamine cross-links facilitate the reversible structural interconversion of dynamic single-chain polymer nanoparticles into linear polymer chains using pH as a trigger.

Responsive single-chain polymer nanoparticles with host–guest features

2015 ◽  
Vol 6 (26) ◽  
pp. 4828-4834 ◽  
Author(s):  
Cunfeng Song ◽  
Longyu Li ◽  
Lizong Dai ◽  
S. Thayumanavan
Keyword(s):  
Random Copolymer ◽  
Polymer Chains ◽  
Polymer Nanoparticles ◽  
Single Chain ◽  
Chain Polymer ◽  
Copolymer Poly

We report a facile approach to form ultra-fine single-chain polymer nanoparticles (SCPNs)viadisulfide-based intrachain crosslinking of single polymer chains of a random copolymer poly(HEMA-co-PDSEMA).

scholarly journals Efficient Synthesis of Single-Chain Polymer NanoparticlesviaAmide Formation

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Ana Sanchez-Sanchez ◽  
José A. Pomposo
Keyword(s):  
Polymer Chains ◽  
Size Exclusion ◽  
Proton Nuclear Magnetic Resonance ◽  
Efficient Synthesis ◽  
Single Chain ◽  
Chain Polymer ◽  
H Nmr ◽  
Exclusion Chromatography ◽  
Methylene Groups

Single-chain technology (SCT) allows the transformation of individual polymer chains to folded/collapsed unimolecular soft nanoparticles. In this work we contribute to the enlargement of the SCT toolbox by demonstrating the efficient synthesis of single-chain polymer nanoparticles (SCNPs)viaintrachain amide formation. In particular, we exploit cross-linking between active methylene groups and isocyanate moieties as powerful “click” chemistry driving force for SCNP construction. By employing poly(methyl methacrylate)- (PMMA-) based copolymers bearingβ-ketoester units distributed randomly along the copolymer chains and bifunctional isocyanate cross-linkers, SCNPs were successfully synthesized at r.t. under appropriate reaction conditions. Characterization of the resulting SCNPs was carried out by means of a combination of techniques including size exclusion chromatography (SEC), infrared (IR) spectroscopy, proton nuclear magnetic resonance (1H NMR) spectroscopy, dynamic light scattering (DLS), and elemental analysis (EA).

Folding polymer chains with visible light

2018 ◽  
Vol 54 (28) ◽  
pp. 3476-3479 ◽  
Author(s):  
Carolin Heiler ◽  
Simon Bastian ◽  
Paul Lederhose ◽  
James P. Blinco ◽  
Eva Blasco ◽  
...  
Keyword(s):  
Visible Light ◽  
Polymer Chains ◽  
Polymer Nanoparticles ◽  
Single Chain ◽  
Chain Polymer ◽  
Versatile Tool

A simple and versatile tool for generating fluorescent single chain polymer nanoparticles with visible light.

Chemiluminescent self-reported unfolding of single-chain nanoparticles

2021 ◽  
Author(s):  
Fabian R. Bloesser ◽  
Sarah L. Walden ◽  
Ishrath M. Irshadeen ◽  
Lewis C. Chambers ◽  
Christopher Barner-Kowollik
Keyword(s):  
Polymer Chains ◽  
Linear Polymer ◽  
Single Chain

We demonstrate the light-induced, crosslinker mediated collapse of linear polymer chains into single-chain nanoparticles (SCNPs) capable of self-reporting their unfolding.

scholarly journals [4+4] anthracene photodimerization for controlled folding of single chain polymer nanoparticles

2020 ◽  
Author(s):  
Dagmar D'hooge ◽  
Christopher Barner-Kowollik ◽  
Anastasia Kislyak ◽  
Francisco Arraez ◽  
Daniel Kodura ◽  
...  
Keyword(s):  
Polymer Nanoparticles ◽  
Single Chain ◽  
Chain Polymer

Single-Chain Polymer Nanoparticles for Application in Nanomedicine

2020 ◽  
pp. 23-46
Author(s):  
Ibon Odriozola ◽  
Miren Karmele Aiertza ◽  
Germán Cabañero ◽  
Hans-Jürgen Grande ◽  
Iraida Loinaz
Keyword(s):  
Polymer Nanoparticles ◽  
Single Chain ◽  
Chain Polymer
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