scholarly journals Polyphenol-Rich Strawberry Extract Protects Human Dermal Fibroblasts against Hydrogen Peroxide Oxidative Damage and Improves Mitochondrial Functionality

Molecules ◽  
2014 ◽  
Vol 19 (6) ◽  
pp. 7798-7816 ◽  
Author(s):  
Francesca Giampieri ◽  
José Alvarez-Suarez ◽  
Luca Mazzoni ◽  
Tamara Forbes-Hernandez ◽  
Massimiliano Gasparrini ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Oxidative Damage ◽  
Dermal Fibroblasts ◽  
Human Dermal Fibroblasts

Hydrogen peroxide enhanced Ca2+-activated BK currents and promoted cell injury in human dermal fibroblasts

Life Sciences ◽  
2012 ◽  
Vol 90 (11-12) ◽  
pp. 424-431 ◽  
Author(s):  
Bing Feng ◽  
Wen-Lei Ye ◽  
Lai-ji Ma ◽  
Yun Fang ◽  
Yan-Ai Mei ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Cell Injury ◽  
Dermal Fibroblasts ◽  
Human Dermal Fibroblasts

scholarly journals The protective effect of acerola (Malpighia emarginata) against oxidative damage in human dermal fibroblasts through the improvement of antioxidant enzyme activity and mitochondrial functionality

2017 ◽  
Vol 8 (9) ◽  
pp. 3250-3258 ◽  
Author(s):  
José M. Alvarez-Suarez ◽  
Francesca Giampieri ◽  
Massimiliano Gasparrini ◽  
Luca Mazzoni ◽  
Celestino Santos-Buelga ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Oxidative Damage ◽  
Protective Effect ◽  
Antioxidant Enzyme ◽  
Bioactive Compounds ◽  
Antioxidant Enzyme Activity ◽  
Dermal Fibroblasts ◽  
Natural Source ◽  
Human Dermal Fibroblasts ◽  
Malpighia Emarginata

Acerola fruits are shown as an important natural source of bioactive compounds with beneficial properties for health.

scholarly journals Prevention of UVA-Induced Oxidative Damage in Human Dermal Fibroblasts by New UV Filters, Assessed Using a Novel In Vitro Experimental System

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e83401 ◽  
Author(s):  
Francesca Brugè ◽  
Luca Tiano ◽  
Paola Astolfi ◽  
Monica Emanuelli ◽  
Elisabetta Damiani
Keyword(s):  
Oxidative Damage ◽  
Experimental System ◽  
Dermal Fibroblasts ◽  
Human Dermal Fibroblasts ◽  
Uv Filters

scholarly journals Pechiche (Vitex cymosa Berteo ex Speng), a Nontraditional Fruit from Ecuador, is a Dietary Source of Phenolic Acids and Nutrient Minerals, in Addition to Efficiently Counteracting the Oxidative-Induced Damage in Human Dermal Fibroblasts

Antioxidants ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 109
Author(s):  
Mabel Guevara ◽  
Luis A. Valdés-Silverio ◽  
María G. Granda-Albuja ◽  
Gabriel Iturralde ◽  
Tatiana Jaramillo-Vivanco ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Enzymes ◽  
Oxidative Damage ◽  
Phenolic Acids ◽  
Glutathione Transferase ◽  
Dermal Fibroblasts ◽  
Human Dermal Fibroblasts ◽  
Atp Levels ◽  
Intracellular Ros ◽  
Phosphorus And Potassium

Pechiche fruits (Vitex cymosa Berteo ex Speng) from Ecuador were studied to determine their phenolic acid profile, nutrient minerals and capacity to protect primary human dermal fibroblasts (HDFa) against oxidative-induced damage. Up to five phenolic acids were identified, with homovanillic acid as the main one. Vitamin C, β-carotene and lutein were also determined. Phosphorus and potassium were the main macrominerals, while iron was the principal micromineral. HDFa were preincubated with a crude pechiche extract (PCext) and then subjected to oxidative stress. The activity of five antioxidant enzymes, intracellular reactive oxygen species (ROS) and ATP levels and lipid peroxidation and protein oxidation were used as markers of oxidative damage. Preincubation with PCext for 24 h allowed for the significant reduction of intracellular ROS levels, improved the intracellular ATP levels and protected lipids and proteins against oxidative damage (p < 0.05). Additionally, preincubation with PCext was also able to significantly (p < 0.05) improve the activity of the antioxidant enzymes catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase and glutathione transferase, compared to the stressed group without pretreatment. The results obtained in this study suggest the potential of pechiche as a source of bioactive compounds, as well as its beneficial effect against oxidative stress.

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