scholarly journals Dietary Organic Acids Modulate Gut Microbiota and Improve Growth Performance of Nursery Pigs

2021 ◽  
Vol 9 (1) ◽  
pp. 110
Author(s):  
Xiaoyuan Wei ◽  
Kristopher A. Bottoms ◽  
Hans H. Stein ◽  
Laia Blavi ◽  
Casey L. Bradley ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Benzoic Acid ◽  
Organic Acids ◽  
Growth Performance ◽  
Sodium Butyrate ◽  
Feed Additives ◽  
Potential Health ◽  
Nursery Pigs ◽  
Microbiota Analysis ◽  
Weaning Pigs

Feed additives have been suggested to improve animal growth performance through modulating the gut microbiota. The hypothesis of this study was that the combination of two organic acids would exert synergistic effects on the growth performance and gut microbiota of weaning pigs. To test this hypothesis, we followed 398 weaning pigs from two university experiment stations (University of Illinois at Urbana-Champaign (UIUC) and University of Arkansas (UA)) to determine the effects of increasing levels (0%, 0.035%, 0.070%, and 0.105%) of sodium butyrate combined with 0.5% benzoic acid on the growth performance of nursery pigs. At the UA, an additional negative control diet was included and the gut microbiota analysis was carried out. At both universities, increasing levels of sodium butyrate in a diet containing 0.5% benzoic acid improved growth performance, which reached a plateau in the pigs fed 0.035% (SBA0.035) or 0.070% (SBA0.070) butyrate. Gut microbiota analysis revealed that pigs fed the SBA0.035 diet had more diverse microbiota and contained more potentially beneficial bacteria such as Oscillospira, Blautia, and Turicibacter and reduced levels of Veillonella and Sarcina. Results of the present study indicated that the inclusion of sodium butyrate at moderate levels in a diet containing 0.5% benzoic acid improved growth performance of weaning pigs and established potential health benefits on gut microbiota.

scholarly journals Weaning Induced Gut Dysfunction and Nutritional Interventions in Nursery Pigs: A Partial Review

Animals ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1279
Author(s):  
Xiaoyuan Wei ◽  
Tsungcheng Tsai ◽  
Samantha Howe ◽  
Jiangchao Zhao
Keyword(s):  
Gut Microbiota ◽  
Growth Performance ◽  
Stressful Events ◽  
Poor Growth ◽  
Nutritional Interventions ◽  
Nursery Pigs ◽  
Gut Dysfunction ◽  
Complex Ecosystem ◽  
Weaning Pigs ◽  
Gut Microbiota Dysbiosis

Weaning is one of the most stressful events in the life of a pig. Unsuccessful weaning often leads to intestinal and immune system dysfunctions, resulting in poor growth performance as well as increased morbidity and mortality. The gut microbiota community is a complex ecosystem and is considered an “organ,” producing various metabolites with many beneficial functions. In this review, we briefly introduce weaning-associated gut microbiota dysbiosis. Then, we explain the importance of maintaining a balanced gut microbiota. Finally, we discuss dietary supplements and their abilities to restore intestinal balance and improve the growth performance of weaning pigs.

scholarly journals Coix seed improves growth performance and productivity in post-weaning pigs by reducing gut pH and modulating gut microbiota

AMB Express ◽  
2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Zhaolong Li ◽  
Zhongning Lin ◽  
Zheng Lu ◽  
Zhihua Feng ◽  
Qi Chen ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Growth Performance ◽  
Coix Seed ◽  
Weaning Pigs ◽  
Gut Ph

scholarly journals PSVIII-16 The effects of adding two organic acid blends with or without high levels of zinc or copper, on post-weaning pig performance

2020 ◽  
Vol 98 (Supplement_3) ◽  
pp. 209-210
Author(s):  
Casey L Bradley ◽  
Jon Bergstrom ◽  
Jeremiah Nemechek ◽  
J D Hahn
Keyword(s):  
Phosphoric Acid ◽  
Benzoic Acid ◽  
Organic Acids ◽  
Organic Acid ◽  
Factorial Design ◽  
Sodium Butyrate ◽  
Weaned Pigs ◽  
Weaning Pig ◽  
Pig Performance ◽  
Dietary Treatments

Abstract A subset of 720 weaned pigs (6.44 ± 0.1 kg, PIC genetics, approximately 21-d of age) were used in a 42-d trial with a 2x3 factorial design evaluating the effects of adding organic acid (OA) blends [factor 1 = no organic acid (NO), Acid Pak 1 (AP1), Acid Pak 2 (AP2)] to diets with or without higher levels of Zn or Cu [factor 2 = +/-PZC] on pig performance. Pigs were allotted 10 pigs/pen to 12 weight blocks and randomly assigned the six dietary treatments. The +PZC diets contained 3000 ppm Zn (d 0-7), 2000 ppm Zn (d 8-21), and 250 ppm Cu (d 21-42) and -PZC diets contained 95 ppm Zn and 20 ppm Cu (d 0-42). The AP1 and AP2 diets used 0.9% of 2 acid premixes (d 0-21), and 0.45% of the premixes (day 22-42). AP1 provided 0.5% benzoic acid, 0.07% sodium butyrate, and 0.025% phosphoric acid (day 0-21) and half those levels (day 22-42). AP2 included the same acids as AP1 but at half the rate and combined with 7 other organic acids and carvacrol. From d 0-21, ADG, ADFI, and G:F were improved (P< 0.01) by +PZC compared to -PZC and by AP1 or AP2 compared to NO (P< 0.02). Overall (d 0-42), ADG and G:F were improved (P< 0.01) by +PZC compared to -PZC and by AP1 or AP2 compared to NO (P< .010). Data from this trial indicate that performance was improved by the addition of both OA and PZC. However, pigs fed OA and -PZC performed similarly to those fed NO and +PZC in the post-weaning period. In summary, regardless of the acid combination, organic acid supplementation has the potential to improve growth performance in weaned pigs.

Effect of supplementation of nicotinamide and sodium butyrate on the growth performance, liver mitochondrial function and gut microbiota of broilers at high stocking density

2019 ◽  
Vol 10 (11) ◽  
pp. 7081-7090 ◽  
Author(s):  
Yuqin Wu ◽  
Youli Wang ◽  
Dafei Yin ◽  
Wei Wu ◽  
Xiaoying Sun ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Antioxidant Capacity ◽  
Growth Performance ◽  
Sodium Butyrate ◽  
Mitochondrial Function ◽  
Stocking Density

Dietary supplemental with nicotinamide and butyrate sodium improve mitochondrial function, antioxidant capacity, and gut microbiota.

scholarly journals Butyric and Citric Acids and Their Salts in Poultry Nutrition: Effects on Gut Health and Intestinal Microbiota

2021 ◽  
Vol 22 (19) ◽  
pp. 10392
Author(s):  
Mebratu Melaku ◽  
Ruqing Zhong ◽  
Hui Han ◽  
Fan Wan ◽  
Bao Yi ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Organic Acids ◽  
Growth Performance ◽  
Pathogenic Bacteria ◽  
Intestinal Inflammation ◽  
Farm Animals ◽  
Gut Health ◽  
Intestinal Health ◽  
Poultry Products ◽  
Poultry Nutrition

Intestinal dysfunction of farm animals, such as intestinal inflammation and altered gut microbiota, is the critical problem affecting animal welfare, performance and farm profitability. China has prohibited the use of antibiotics to improve feed efficiency and growth performance for farm animals, including poultry, in 2020. With the advantages of maintaining gut homeostasis, enhancing digestion, and absorption and modulating gut microbiota, organic acids are regarded as promising antibiotic alternatives. Butyric and citric acids as presentative organic acids positively impact growth performance, welfare, and intestinal health of livestock mainly by reducing pathogenic bacteria and maintaining the gastrointestinal tract (GIT) pH. This review summarizes the discovery of butyric acid (BA), citric acid (CA) and their salt forms, molecular structure and properties, metabolism, biological functions and their applications in poultry nutrition. The research findings about BA, CA and their salts on rats, pigs and humans are also briefly reviewed. Therefore, this review will fill the knowledge gaps of the scientific community and may be of great interest for poultry nutritionists, researchers and feed manufacturers about these two weak organic acids and their effects on intestinal health and gut microbiota community, with the hope of providing safe, healthy and nutrient-rich poultry products to consumers.

scholarly journals Evaluation of diet complexity and benzoic acid on growth performance of nursery pigs

2013 ◽  
pp. 35-41 ◽  
Author(s):  
J E Nemechek ◽  
Michael D Tokach ◽  
Steven S Dritz ◽  
Robert D Goodband ◽  
Joel M DeRouchey ◽  
...  
Keyword(s):  
Benzoic Acid ◽  
Growth Performance ◽  
Nursery Pigs

scholarly journals Effect of Lactylate and Bacillus subtilis on Growth Performance, Peripheral Blood Cell Profile, and Gut Microbiota of Nursery Pigs

2021 ◽  
Vol 9 (4) ◽  
pp. 803
Author(s):  
Xiaofan Wang ◽  
Tsungcheng Tsai ◽  
Xiaoyuan Wei ◽  
Bin Zuo ◽  
Ellen Davis ◽  
...  
Keyword(s):  
Bacillus Subtilis ◽  
Gut Microbiota ◽  
Blood Cell ◽  
Growth Performance ◽  
Cell Count ◽  
Phase 1 ◽  
Feed Ratio ◽  
Blood Cell Count ◽  
Nursery Pigs ◽  
E Coli

To evaluate the effects of lactylate and Bacillus subtilis on growth performance, complete blood cell count, and microbial changes, 264 weaning pigs were assigned to four treatments (1) control (Con) basal diets that met the nutrient requirement for each phase, (2) 0.2% lactylate (LA), (3) 0.05% Bacillus subtilis strains mixtures (BM), or (4) the combination of LA and BM (LA+BM) added to the control basal diet at their respective inclusion rates in each of the three phases. Dietary lactylate tended to increase weight gain, significantly increased feed intake, and reduced fecal total E. coli and enterotoxigenic E. coli counts during Phase 1. Pigs fed Bacillus subtilis had a greater gain to feed ratio (G:F) during Phases 1 and 2. Pigs fed lactylate had an increased peripheral absolute neutrophil count on D14 but a decreased eosinophil percentage. Pigs fed Bacillus subtilis had an elevated peripheral total white blood cell count at study completion. The addition of lactylate increased microbiota richness, reduced E. coli, and increased Prevotella, Christensenellaceae, and Succinivibrio. Bacillus subtilis supplementation-enriched f_Ruminococcaceae_unclassified and S24-7_ unclassified had positive relationships with feed efficiency. Collectively, these findings suggested that lactylate can be added to diets to balance gut microbiota and improve growth performance during the early postweaning period. The combination of lactylate and Bacillus subtilis strains exerted a synergic effect on the growth performance of nursery pigs.

384 Effects of dietary supplementation of natural feed additives on growth performance of nursery pigs

2017 ◽  
Vol 95 (suppl_4) ◽  
pp. 190-190
Author(s):  
S. M. Mendoza ◽  
G. R. Murugesan ◽  
E. G. Hendel ◽  
E. Kadas-Toth ◽  
A. Kovacs
Keyword(s):  
Growth Performance ◽  
Dietary Supplementation ◽  
Feed Additives ◽  
Nursery Pigs
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