scholarly journals Weaning Induced Gut Dysfunction and Nutritional Interventions in Nursery Pigs: A Partial Review

Animals ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1279
Author(s):  
Xiaoyuan Wei ◽  
Tsungcheng Tsai ◽  
Samantha Howe ◽  
Jiangchao Zhao
Keyword(s):  
Gut Microbiota ◽  
Growth Performance ◽  
Stressful Events ◽  
Poor Growth ◽  
Nutritional Interventions ◽  
Nursery Pigs ◽  
Gut Dysfunction ◽  
Complex Ecosystem ◽  
Weaning Pigs ◽  
Gut Microbiota Dysbiosis

Weaning is one of the most stressful events in the life of a pig. Unsuccessful weaning often leads to intestinal and immune system dysfunctions, resulting in poor growth performance as well as increased morbidity and mortality. The gut microbiota community is a complex ecosystem and is considered an “organ,” producing various metabolites with many beneficial functions. In this review, we briefly introduce weaning-associated gut microbiota dysbiosis. Then, we explain the importance of maintaining a balanced gut microbiota. Finally, we discuss dietary supplements and their abilities to restore intestinal balance and improve the growth performance of weaning pigs.

scholarly journals Dietary Organic Acids Modulate Gut Microbiota and Improve Growth Performance of Nursery Pigs

2021 ◽  
Vol 9 (1) ◽  
pp. 110
Author(s):  
Xiaoyuan Wei ◽  
Kristopher A. Bottoms ◽  
Hans H. Stein ◽  
Laia Blavi ◽  
Casey L. Bradley ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Benzoic Acid ◽  
Organic Acids ◽  
Growth Performance ◽  
Sodium Butyrate ◽  
Feed Additives ◽  
Potential Health ◽  
Nursery Pigs ◽  
Microbiota Analysis ◽  
Weaning Pigs

Feed additives have been suggested to improve animal growth performance through modulating the gut microbiota. The hypothesis of this study was that the combination of two organic acids would exert synergistic effects on the growth performance and gut microbiota of weaning pigs. To test this hypothesis, we followed 398 weaning pigs from two university experiment stations (University of Illinois at Urbana-Champaign (UIUC) and University of Arkansas (UA)) to determine the effects of increasing levels (0%, 0.035%, 0.070%, and 0.105%) of sodium butyrate combined with 0.5% benzoic acid on the growth performance of nursery pigs. At the UA, an additional negative control diet was included and the gut microbiota analysis was carried out. At both universities, increasing levels of sodium butyrate in a diet containing 0.5% benzoic acid improved growth performance, which reached a plateau in the pigs fed 0.035% (SBA0.035) or 0.070% (SBA0.070) butyrate. Gut microbiota analysis revealed that pigs fed the SBA0.035 diet had more diverse microbiota and contained more potentially beneficial bacteria such as Oscillospira, Blautia, and Turicibacter and reduced levels of Veillonella and Sarcina. Results of the present study indicated that the inclusion of sodium butyrate at moderate levels in a diet containing 0.5% benzoic acid improved growth performance of weaning pigs and established potential health benefits on gut microbiota.

scholarly journals Coix seed improves growth performance and productivity in post-weaning pigs by reducing gut pH and modulating gut microbiota

AMB Express ◽  
2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Zhaolong Li ◽  
Zhongning Lin ◽  
Zheng Lu ◽  
Zhihua Feng ◽  
Qi Chen ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Growth Performance ◽  
Coix Seed ◽  
Weaning Pigs ◽  
Gut Ph

PSIV-19 Flavors and Sweeteners in Nursery Pig Diets Increased Intake and Reduced Soft Feces in the First Weeks After Weaning

2021 ◽  
Vol 99 (Supplement_1) ◽  
pp. 179-180
Author(s):  
Jorge Y Perez-Palencia ◽  
Xixi Chen ◽  
Jirong Lv ◽  
Maíra Resende ◽  
Rhuan F Chaves ◽  
...  
Keyword(s):  
Growth Performance ◽  
Feed Intake ◽  
Block Design ◽  
Phase 1 ◽  
Poor Performance ◽  
Stressful Events ◽  
Gut Health ◽  
Nursery Pigs ◽  
Feeding Program ◽  
Dietary Treatments

Abstract The stressful events associated with weaning predispose piglets to reduced feed intake, which in concert with immature digestive and immune systems, results in increased incidences of diarrhea and poor performance. Flavors and sweeteners can be used in diets for young pigs as a means of attracting them to dry feed and increase their feed intake and performance after weaning. The objective of this study was to evaluate the effects of dietary inclusion of flavors and sweeteners and their combination on growth performance and post-weaning gut health of nursery pigs. A total of 1,144 weaned pigs (initial BW 6.61 ± 0.2 kg) were used in a randomized complete block design and assigned to one of four dietary treatments, with 11 replicates (pens) of 26 piglets per pen. Dietary treatments were 1) Control: standard 4-phase nursery feeding program; 2) Sweetener: control plus sweetener (0.015%); 3) Flavor: control plus flavoring (0.05%); 4) Combination: control plus sweetener and flavoring. Experimental diets were provided at a budget of 0.9, 3.4, 4.5, and 24 kg/pig in Phase 1, 2, 3, and 4, respectively. A common phase 5 diet was provided ad libitum until d56 after weaning. Feed disappearance and body weight were measured every other week. A pen fecal score assessment was performed at d4, 7, 10, and 14 after weaning. Overall, there were no differences among dietary treatments for growth performance. However, during the first two weeks post-weaning pigs fed diets containing flavors and sweeteners had a greater (P = 0.097) ADFI than control pigs. On d14, pigs fed diets containing flavors and sweeteners had less incidence of soft and watery feces (χ2 < 0.05) compared to control pigs. This study provides evidence that dietary inclusion of flavors and sweeteners has important benefits to the overall health of nursery pigs likely related to feed intake in the period immediately after weaning.

scholarly journals Effect of Lactylate and Bacillus subtilis on Growth Performance, Peripheral Blood Cell Profile, and Gut Microbiota of Nursery Pigs

2021 ◽  
Vol 9 (4) ◽  
pp. 803
Author(s):  
Xiaofan Wang ◽  
Tsungcheng Tsai ◽  
Xiaoyuan Wei ◽  
Bin Zuo ◽  
Ellen Davis ◽  
...  
Keyword(s):  
Bacillus Subtilis ◽  
Gut Microbiota ◽  
Blood Cell ◽  
Growth Performance ◽  
Cell Count ◽  
Phase 1 ◽  
Feed Ratio ◽  
Blood Cell Count ◽  
Nursery Pigs ◽  
E Coli

To evaluate the effects of lactylate and Bacillus subtilis on growth performance, complete blood cell count, and microbial changes, 264 weaning pigs were assigned to four treatments (1) control (Con) basal diets that met the nutrient requirement for each phase, (2) 0.2% lactylate (LA), (3) 0.05% Bacillus subtilis strains mixtures (BM), or (4) the combination of LA and BM (LA+BM) added to the control basal diet at their respective inclusion rates in each of the three phases. Dietary lactylate tended to increase weight gain, significantly increased feed intake, and reduced fecal total E. coli and enterotoxigenic E. coli counts during Phase 1. Pigs fed Bacillus subtilis had a greater gain to feed ratio (G:F) during Phases 1 and 2. Pigs fed lactylate had an increased peripheral absolute neutrophil count on D14 but a decreased eosinophil percentage. Pigs fed Bacillus subtilis had an elevated peripheral total white blood cell count at study completion. The addition of lactylate increased microbiota richness, reduced E. coli, and increased Prevotella, Christensenellaceae, and Succinivibrio. Bacillus subtilis supplementation-enriched f_Ruminococcaceae_unclassified and S24-7_ unclassified had positive relationships with feed efficiency. Collectively, these findings suggested that lactylate can be added to diets to balance gut microbiota and improve growth performance during the early postweaning period. The combination of lactylate and Bacillus subtilis strains exerted a synergic effect on the growth performance of nursery pigs.

scholarly journals 176 Evaluation of a novel threonine source for nursery pig diets

2020 ◽  
Vol 98 (Supplement_3) ◽  
pp. 85-86
Author(s):  
Dalton Humphrey ◽  
Spenser Becker ◽  
Jason Lee ◽  
Keith Haydon ◽  
Laura L Greiner
Keyword(s):  
Growth Performance ◽  
Positive Control ◽  
Negative Control ◽  
Experimental Unit ◽  
Nursery Pigs ◽  
Nursery Pig ◽  
Weaning Pigs ◽  
Dietary Treatments ◽  
Similar Growth ◽  
Source Test

Abstract Four hundred and eighty (PIC 337 X 1050, PIC Genus, Hendersonville, TN) pigs were used to evaluate a novel threonine source (ThrPro, CJ America-Bio, Fort Dodge, IA) for nursery pigs from approximately 7 kg to 20 kg. At weaning, pigs were sorted by gender and fed a common diet for one week. Upon completion of the first week, pigs were sorted into randomized complete blocks, equalized by weight, within 16 replications. Pigs were allocated to one of three dietary treatments: positive control (POS)-SID LYS:THR 0.60, negative control (NEG)-SID LYS:THR ≤0.46 and alternative threonine source (TEST)-SID LYS:THR 0.60. All other nutrients met or exceeded the NRC (2012) recommendations. Growth and intake data were analyzed using PROC MIXED procedure in SAS. The experimental unit was the pen. During the first 14 days, pigs fed TEST had similar ADG (0.417 vs. 0.414 kg/d, P=0.81) and G:F (0.977 vs. 1.030, P=0.18) compared to POS, and increased ADG (0.417 vs. 0.387 kg/d, P=0.01) and G:F (0.977 vs. 0.898, P=0.05) compared to NEG. Over days 14-28, pigs fed TEST had similar ADG (0.523 vs. 0.532 kg/d, P=0.49) and G:F (0.712 vs. 0.707, P=0.71) compared to POS, and increased ADG (0.523 vs. 0.479 kg/d, P=0.002) and G:F (0.712 vs. 0.627, P< 0.0001) compared to NEG. Overall (d 0 to 28), pigs fed TEST had similar ADG (0.466 vs. 0.474 kg/d, P=0.48) and G:F (0.808 vs. 0.816, P=0.55) compared to POS, and increased ADG (0.466 vs. 0.433 kg/d, P=0.002) and G:F (0.808 vs. 0.725, P< 0.0001) compared to NEG. ADFI was not significantly different across treatments for the entirety of the study. In conclusion, the replacement of L-threonine with a novel threonine source resulted in similar growth performance in nursery pigs from approximately 7 kg to 20 kg.

94 The Effects of Dietary Crude Protein, Acidifier, and Pharmacological Levels of Zinc on Growth Performance of Nursery Pigs

2021 ◽  
Vol 99 (Supplement_1) ◽  
pp. 47-48
Author(s):  
Wade M Hutchens ◽  
Mike D Tokach ◽  
Jason C Woodworth ◽  
Joel M DeRouchey ◽  
Robert D Goodband ◽  
...  
Keyword(s):  
Growth Performance ◽  
Crude Protein ◽  
Dry Matter ◽  
Phase 1 ◽  
Nursery Pigs ◽  
Dietary Crude Protein ◽  
Nursery Pig ◽  
Weaning Pigs ◽  
Pig Performance ◽  
Main Effects

Abstract Weanling pigs (n = 360, DNA 200 × 400, initially 5.90 kg) were used to evaluate pharmacological levels of Zn (ZnO), diet acidification (sodium diformate; Addcon, Bitterfeld-Wolfen, Germany), and crude protein (18 or 21% CP) on pig performance. At weaning, pigs were assigned to treatments with 5 pigs/pen and 9 pens/treatment. Treatments were arranged in a 2×2×2 factorial with main effects of Zn (110 mg/kg from d 0 to 21 or 3,000 mg/kg from d 0 to 7, and 2,000 mg/kg from d 7 to 21), diet acidification (without or with 1.2% sodium diformate), and dietary CP (21 or 18%). The 21% CP diets were formulated to 1.40 and 1.35% SID Lys in phase 1 and 2, respectively, and 18% CP diets were formulated to 1.20% SID Lys. Experimental diets were fed from d 0 to 21 with a common diet from d 21 to 42. Fecal samples were collected weekly to determine fecal dry matter (DM). Data were analyzed using R Studio as a RCBD. From d 0 to 21, ADG and G:F increased (P < 0.05) for pigs fed pharmacological Zn, and sodium diformate. Overall, ADG tended (P ≤ 0.069) to increase for pigs fed added Zn or sodium diformate. Pigs fed 21% CP had increased (P < 0.05) ADG and G:F from d 0 to 21 and overall G:F compared with those fed 18% CP. Feeding 18% CP diets increased fecal dry matter on d 7 when pharmacological Zn and sodium diformate were not in the diet (Zn×acidifier×CP interaction, P < 0.05). From d 21 to 42, there was no evidence of difference in growth performance. In conclusion, reducing CP without acidification increased fecal DM when pharmacological Zn were not in the diet, but had little effect when it was in the diet. Adding sodium diformate and pharmacological Zn independently improved nursery pig growth performance.

scholarly journals ZnO Modulates Swine Gut Microbiota and Improves Growth Performance of Nursery Pigs When Combined with Peptide Cocktail

2020 ◽  
Vol 8 (2) ◽  
pp. 146 ◽  
Author(s):  
Xiaoyuan Wei ◽  
Tsungcheng Tsai ◽  
Joshua Knapp ◽  
Kristopher Bottoms ◽  
Feilong Deng ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Growth Performance ◽  
Rectal Swab ◽  
Average Daily Gain ◽  
Swine Production ◽  
Deficient Diet ◽  
Nursery Pigs ◽  
High Zinc ◽  
Daily Gain ◽  
Different Levels

Zinc has been very efficacious in reducing post-weaning diarrhea, whereas animal-derived peptides are suggested to improve the growth performance of weaned piglets. However, the combined effect of zinc and peptides on swine production and swine gut microbiota is still largely unknown. In this study, we followed 288 nursery pigs from the age of d30 to d60 to evaluate the growth performance and gut microbiota of weanling pigs subjected to different levels of a fish-porcine-microbial peptide cocktail (0.05%, 0.25%, and 0.5%) with or without the pharmaceutical level of zinc oxide (ZnO) (2500 ppm) supplementation in a nutrient-deficient diet. Rectal swab samples were collected from pigs with body weight (BW) approach average at each pen on d30, d42, and d60 to determine gut microbiota. Average daily gain (ADG) and BW in piglets fed high zinc (HZ) increased with increasing levels of peptide. The microbiota of the HZ group also diverged from those of the standard zinc (SZ) group from d30 to d60. Adding peptide did not alter community structure regardless of zinc supplementation. Collectively, these findings demonstrated that the pharmaceutical level of zinc as ZnO conditioned the gut community to the point where peptide could effectively restore growth performance in nursery pigs fed nutrient-deficient diets.

Severe Gut Microbiota Dysbiosis Is Associated With Poor Growth in Patients With Short Bowel Syndrome

2016 ◽  
Vol 41 (7) ◽  
pp. 1202-1212 ◽  
Author(s):  
Hannah G. Piper ◽  
Di Fan ◽  
Laura A. Coughlin ◽  
Evi X. Ho ◽  
Margaret M. McDaniel ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Short Bowel Syndrome ◽  
Poor Growth ◽  
Short Bowel ◽  
Gut Microbiota Dysbiosis
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