Effect of supplementation of nicotinamide and sodium butyrate on the growth performance, liver mitochondrial function and gut microbiota of broilers at high stocking density

2019 ◽  
Vol 10 (11) ◽  
pp. 7081-7090 ◽  
Author(s):  
Yuqin Wu ◽  
Youli Wang ◽  
Dafei Yin ◽  
Wei Wu ◽  
Xiaoying Sun ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Antioxidant Capacity ◽  
Growth Performance ◽  
Sodium Butyrate ◽  
Mitochondrial Function ◽  
Stocking Density

Dietary supplemental with nicotinamide and butyrate sodium improve mitochondrial function, antioxidant capacity, and gut microbiota.

scholarly journals Dietary Organic Acids Modulate Gut Microbiota and Improve Growth Performance of Nursery Pigs

2021 ◽  
Vol 9 (1) ◽  
pp. 110
Author(s):  
Xiaoyuan Wei ◽  
Kristopher A. Bottoms ◽  
Hans H. Stein ◽  
Laia Blavi ◽  
Casey L. Bradley ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Benzoic Acid ◽  
Organic Acids ◽  
Growth Performance ◽  
Sodium Butyrate ◽  
Feed Additives ◽  
Potential Health ◽  
Nursery Pigs ◽  
Microbiota Analysis ◽  
Weaning Pigs

Feed additives have been suggested to improve animal growth performance through modulating the gut microbiota. The hypothesis of this study was that the combination of two organic acids would exert synergistic effects on the growth performance and gut microbiota of weaning pigs. To test this hypothesis, we followed 398 weaning pigs from two university experiment stations (University of Illinois at Urbana-Champaign (UIUC) and University of Arkansas (UA)) to determine the effects of increasing levels (0%, 0.035%, 0.070%, and 0.105%) of sodium butyrate combined with 0.5% benzoic acid on the growth performance of nursery pigs. At the UA, an additional negative control diet was included and the gut microbiota analysis was carried out. At both universities, increasing levels of sodium butyrate in a diet containing 0.5% benzoic acid improved growth performance, which reached a plateau in the pigs fed 0.035% (SBA0.035) or 0.070% (SBA0.070) butyrate. Gut microbiota analysis revealed that pigs fed the SBA0.035 diet had more diverse microbiota and contained more potentially beneficial bacteria such as Oscillospira, Blautia, and Turicibacter and reduced levels of Veillonella and Sarcina. Results of the present study indicated that the inclusion of sodium butyrate at moderate levels in a diet containing 0.5% benzoic acid improved growth performance of weaning pigs and established potential health benefits on gut microbiota.

scholarly journals Effects of Clostridium butyricum, Sodium Butyrate, and Butyric Acid Glycerides on the Reproductive Performance, Egg Quality, Intestinal Health, and Offspring Performance of Yellow-Feathered Breeder Hens

2021 ◽  
Vol 12 ◽  
Author(s):  
Yibing Wang ◽  
Yang Wang ◽  
Xiajing Lin ◽  
Zhongyong Gou ◽  
Qiuli Fan ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Growth Performance ◽  
Butyric Acid ◽  
Sodium Butyrate ◽  
Reproductive Performance ◽  
Egg Quality ◽  
Intestinal Morphology ◽  
Intestinal Health ◽  
Offspring Performance ◽  
Breeder Hens

Butyrate has been reported to promote the performance and growth of chickens. The specific roles and efficacy of different sources of butyrate remained unclear. Thus, the present study aimed to investigate and compare the effects of Clostridium butyricum (CB), sodium butyrate (SB), and butyric acid glycerides (tributyrin, BAG) on the reproductive performance, egg quality, intestinal health, and offspring performance of yellow-feathered breeder hens. A total of 300 Lingnan yellow-feathered breeder hens were assigned to five treatment groups: control (CL), 1×108CFU/kg CB (CBL), 1×109CFU/kg CB (CBH), 500mg/kg SB, and 300mg/kg BAG. Results showed that the laying performance and egg quality were increased by CBL, CBH, and BAG. Both CB treatments increased the hatchability of fertilized eggs. Maternal supplementation with both levels of CB significantly elevated the growth performance of offspring. Treatment with CBL, CBH, SB, and BAG all improved the oviduct-related variables and reduced the plasmal antioxidant variables. The CBH, CBL, and BAG treatments also improved the intestinal morphology to different degrees. Jejunal contents of IL-6 were decreased by CBH and BAG, while those of IL-4, IL-6, IL-1β, and IgY were decreased by SB. Transcripts of nutrient transporters in jejunal mucosa were also upregulated by CBH, CBL, and SB treatments and expression of Bcl-2-associated X protein was decreased by CBL, CBH, and BAG. In cecal contents, CBL increased the abundance of Firmicutes and Bacillus, while CBH decreased the abundance of Proteobacteria. Also, the co-occurrence networks of intestinal microbes were regulated by CBH and BAG. In conclusion, dietary inclusion of CB and BAG improved the reproductive parameters, egg quality, and intestinal morphology of breeders. CB also influenced the hatching performance of breeders and growth performance of the offspring, while SB improved the oviduct-related variables. These beneficial effects may result from the regulation of cytokines, nutrient transporters, apoptosis, and gut microbiota; high-level CB had more obvious impact. Further study is needed to explore and understand the correlation between the altered gut microbiota induced by butyrate and the performance, egg quality, intestinal health, and also offspring performance.

scholarly journals Effects of Clostridium butyricum on Growth Performance, Gut Microbiota and Intestinal Barrier Function of Broilers

2021 ◽  
Vol 12 ◽  
Author(s):  
Wenjia Li ◽  
Bin Xu ◽  
Linyi Wang ◽  
Quanyou Sun ◽  
Wen Deng ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Growth Performance ◽  
Barrier Function ◽  
Stocking Density ◽  
Intestinal Barrier ◽  
Basal Diet ◽  
The Body ◽  
Clostridium Butyricum ◽  
Intestinal Barrier Function ◽  
Significant Difference

This study was conducted to evaluate the effects of Clostridium butyricum dietary supplementation on the growth, antioxidant, immune response, gut microbiota, and intestinal barrier function of broilers under high stocking density (HSD) stress. A total of 324 1-day-old Arbor Acres male broilers were randomly assigned to three treatments with six replicates, each replicate including 18 chickens (18 birds/m2). The experiment lasted 6 weeks. The three treatments were basal diet (control, CON), basal diet supplemented with 1 × 109 colony forming units (cfu)/kg C. butyricum (CB), and basal diet supplemented with 10 mg/kg virginiamycin (antibiotic, ANT). The results showed that the body weight (BW) and average daily gain (ADG) of broilers in the CB group were significantly higher than those in the CON group in three periods (p < 0.05). The total antioxidant capacity (T-AOC) and the superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity in serum of the CB group were significantly increased compared with those in the CON and ANT groups at 42 days (p < 0.05). At 42 days, the serum immunoglobulin M (IgM) and immunoglobulin G (IgG) levels of the CB group were significantly higher than those of the CON group. Compared with the CON group, interleukin-1β (IL-1β) in the CB group was significantly decreased in the starter and grower stages (p < 0.05), but there was no significant difference between the two treatment groups (p > 0.05). C. butyricum significantly decreased the high stocking density-induced expression levels of IL-1β and tumor necrosis factor-α (TNF-α) in the ileum of broilers at different stages. Additionally, C. butyricum could increase the expressions of claudin-1 and zonula occludens-1 (ZO-1) in intestinal tissue. Moreover, C. butyricum significantly increased the Sobs and Shannon indices in the CB group compared with the ANT group (p < 0.05), while the Ace index in the CB group was significantly higher than that of the CON group (p < 0.05). Furthermore, by using 16S rRNA gene sequencing, the proportion of Bacteroides in the CB group was increased compared to those in the CON and ANT groups at the genus level. In conclusion, C. butyricum supplemented into feed could improve the growth performance and feed utilization of broilers by promoting immune and intestinal barrier function and benefiting the cecal microflora.

scholarly journals PSVIII-7 Dietary L-arginine supplementation enhances growth performance, intestinal antioxidant capacity, immunity and modulate gut microbiota in yellow feathered chickens

2020 ◽  
Vol 98 (Supplement_4) ◽  
pp. 250-252
Author(s):  
Dong Ruan ◽  
A M Fouad ◽  
Qiuli Fan ◽  
Shouqun Jiang
Keyword(s):  
Gut Microbiota ◽  
Antioxidant Capacity ◽  
Growth Performance ◽  
Average Daily Gain ◽  
Immunoglobulin A ◽  
Sensu Stricto ◽  
Sequencing Data ◽  
Feed Conversion ◽  
Glutathione Peroxidase 1 ◽  
Total Antioxidant

Abstract This study investigated the effects of dietary Arginine (Arg) on performance, intestinal antioxidant capacity, immunity, and gut microbiota in Chinese yellow-feathered chickens. One thousand and two hundred 1-day-old female Qingyuan partridge chickens were randomly assigned to 5 groups with 6 replicates of 40 birds each. Chickens were fed diets with 5 total Arg levels (8.5, 9.7, 10.9, 12.1 and 13.3 g/kg) without antibiotics for 30 D. Average daily feed intake, average daily gain, and feed conversion ratio were improved with dietary Arg levels (P < 0.05). Dietary Arg level had a linear (P < 0.05) or quadratic (P < 0.05) effect on the gene expression of glutathione peroxidase 1, hame oxygenase 1, nuclear factor erythroid 2, linearly and quadraticly increased activities of GSH-Px and total antioxidant capacity in the jejunum and ileum. In addition, relative expression of interleukin-1β and toll-like receptor 4 decreased linearly (P < 0.05) and quadratically (P < 0.05) in the ileum with increasing dietary Arg levels; secretory immunoglobulin A contents were increased. In addition, sequencing data of 16S rRNA indicated that dietary Arg increased the abundances of Firmicutes phylum, Romboutsia and Candidatus Arthromitus genus, while decreased that of Clostridium sensu stricto 1. A diet containing 12.1 g Arg/kg could promote growth performance, intestinal antioxidation, innate immunity and modulate gut microbiota in yellow feathered chickens.

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