scholarly journals 20(R)-ginsenoside Rg3, a product of high-efficiency thermal deglycosylation of ginsenoside Rd, exerts protective effects against scrotal heat-induced spermatogenic damage in mice

BIOCELL ◽  
2020 ◽  
Vol 44 (4) ◽  
pp. 655-669
Author(s):  
WEI LIU ◽  
ZI WANG ◽  
JING LENG ◽  
HENG WEI ◽  
SHEN REN ◽  
...  
Keyword(s):  
High Efficiency ◽  
Protective Effects ◽  
Ginsenoside Rg3 ◽  
Ginsenoside Rd

Protective effects of ginsenoside Rg3 against cyclophosphamide-induced DNA damage and cell apoptosis in mice

2007 ◽  
Vol 82 (2) ◽  
pp. 117-123 ◽  
Author(s):  
Qiu Hua Zhang ◽  
Chun Fu Wu ◽  
Lian Duan ◽  
Jing Yu Yang
Keyword(s):  
Dna Damage ◽  
Cell Apoptosis ◽  
Protective Effects ◽  
Ginsenoside Rg3

scholarly journals Protective effects of the flavonoid fraction obtained from pomelo fruitlets through ultrasonic-associated microwave extraction against AAPH-induced erythrocyte hemolysis

RSC Advances ◽  
2019 ◽  
Vol 9 (28) ◽  
pp. 16007-16017 ◽  
Author(s):  
Qin Wang ◽  
Jieying Luo ◽  
Huifan Liu ◽  
Charles Stephen Brennan ◽  
Jianliang Liu ◽  
...  
Keyword(s):  
High Efficiency ◽  
Side Product ◽  
Protective Effects ◽  
Microwave Extraction ◽  
Erythrocyte Hemolysis ◽  
Flavonoid Compounds ◽  
Flavonoid Fraction

Pomelo fruitlet is a side-product of pomelo, and this study aimed to extract the antioxidative flavonoid compounds from pomelo fruitlets with high efficiency through ultrasonic-associated microwave methods.

scholarly journals Ginsenoside Rg3 Attenuates TNF-α-Induced Damage in Chondrocytes through Regulating SIRT1-Mediated Anti-Apoptotic and Anti-Inflammatory Mechanisms

Antioxidants ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 1972
Author(s):  
Ching-Hou Ma ◽  
Wan-Ching Chou ◽  
Chin-Hsien Wu ◽  
I-Ming Jou ◽  
Yuan-Kun Tu ◽  
...  
Keyword(s):  
P38 Mapk ◽  
Cartilage Degradation ◽  
Protective Effects ◽  
Cyclophilin D ◽  
Ginsenoside Rg3 ◽  
Necrosis Factor Alpha ◽  
Mitochondrial Ros ◽  
Bioactive Component ◽  
Tnf Α ◽  
Matrix Metallopeptidase

The upregulation of tumor necrosis factor-alpha (TNF-α) is a common event in arthritis, and the subsequent signaling cascade that leads to tissue damage has become the research focus. To explore a potential therapeutic strategy to prevent cartilage degradation, we tested the effect of ginsenoside Rg3, a bioactive component of Panax ginseng, on TNF-α-stimulated chondrocytes.TC28a2 Human Chondrocytes were treated with TNF-α to induce damage of chondrocytes. SIRT1 and PGC-1a expression levels were investigated by Western blotting assay. Mitochondrial SIRT3 and acetylated Cyclophilin D (CypD) were investigated using mitochondrial isolation. The mitochondrial mass number and mitochondrial DNA copy were studied for mitochondrial biogenesis. MitoSOX and JC-1 were used for the investigation of mitochondrial ROS and membrane potential. Apoptotic markers, pro-inflammatory events were also tested to prove the protective effects of Rg3. We showed Rg3 reversed the TNF-α-inhibited SIRT1 expression. Moreover, the activation of the SIRT1/PGC-1α/SIRT3 pathway by Rg3 suppressed the TNF-α-induced acetylation of CypD, resulting in less mitochondrial dysfunction and accumulation of reactive oxygen species (ROS). Additionally, we demonstrated that the reduction of ROS ameliorated the TNF-α-elicited apoptosis. Furthermore, the Rg3-reverted SIRT1/PGC-1α/SIRT3 activation mediated the repression of p38 MAPK, which downregulated the NF-κB translocation in the TNF-α-treated cells. Our results revealed that administration of Rg3 diminished the production of interleukin 8 (IL-8) and matrix metallopeptidase 9 (MMP-9) in chondrocytes via SIRT1/PGC-1α/SIRT3/p38 MAPK/NF-κB signaling in response to TNF-α stimulation. Taken together, we showed that Rg3 may serve as an adjunct therapy for patients with arthritis.

scholarly journals Protective Effects of Ginsenoside Rg3

2009 ◽  
Vol 33 (4) ◽  
pp. 294-304 ◽  
Author(s):  
Jong-Hoon Kim
Keyword(s):  
Protective Effects ◽  
Ginsenoside Rg3

Protective effects of ginsenoside Rg3 on human osteoarthritic chondrocytes

2013 ◽  
Vol 23 (1) ◽  
pp. 104-111 ◽  
Author(s):  
Min Wook So ◽  
Eun-Ju Lee ◽  
Han Sang Lee ◽  
Bon San Koo ◽  
Yong-Gil Kim ◽  
...  
Keyword(s):  
Protective Effects ◽  
Ginsenoside Rg3 ◽  
Osteoarthritic Chondrocytes

Protective effects of ginsenoside Rd against okadaic acid-induced neurotoxicity in vivo and in vitro

2011 ◽  
Vol 138 (1) ◽  
pp. 135-141 ◽  
Author(s):  
Ling Li ◽  
Juanfang Liu ◽  
Xiaodong Yan ◽  
Kefeng Qin ◽  
Ming Shi ◽  
...  
Keyword(s):  
Okadaic Acid ◽  
Protective Effects ◽  
Ginsenoside Rd

scholarly journals Protective effects of ginsenoside Rg3 on TNF-α-induced human nucleus pulposus cells through inhibiting NF-κB signaling pathway

Life Sciences ◽  
2019 ◽  
Vol 216 ◽  
pp. 1-9 ◽  
Author(s):  
Jiang Chen ◽  
Gen-Zhe Liu ◽  
Qi Sun ◽  
Fan Zhang ◽  
Chu-yin Liu ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Nucleus Pulposus ◽  
Protective Effects ◽  
Ginsenoside Rg3 ◽  
Nucleus Pulposus Cells ◽  
Tnf Α

Highly efficient biotransformation of ginsenoside Rb1 and Rg3 using β-galactosidase from Aspergillus sp.

RSC Advances ◽  
2015 ◽  
Vol 5 (96) ◽  
pp. 78874-78879 ◽  
Author(s):  
Hui-da Wan ◽  
Dan Li
Keyword(s):  
Ginsenoside Rb1 ◽  
Ginsenoside Rh2 ◽  
Ginsenoside Rg3 ◽  
Ginsenoside Rd ◽  
Highly Efficient ◽  
Rare Ginsenoside ◽  
Aspergillus Sp

β-Galactosidase from Aspergillus sp. can transform major ginsenoside Rb1 to rare ginsenoside F2 via ginsenoside Rd. Ginsenoside Rg3 can be selectively hydrolyzed with this β-galactosidase and only ginsenoside Rh2 was obtained as well.

scholarly journals Protective Effects of Ginsenoside Rd on PC12 Cells against Hydrogen Peroxide

2008 ◽  
Vol 31 (10) ◽  
pp. 1923-1927 ◽  
Author(s):  
Ruidong Ye ◽  
Junliang Han ◽  
Xiangwei Kong ◽  
Lingzhou Zhao ◽  
Rong Cao ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Pc12 Cells ◽  
Protective Effects ◽  
Ginsenoside Rd

Pharmacokinetics and brain distribution studies of ginsenoside Rd in rats via intranasal administration by LC-MS/MS

2015 ◽  
Vol 7 (20) ◽  
pp. 8809-8816 ◽  
Author(s):  
Sali Cao ◽  
Xingbin Yin ◽  
Jing Fu ◽  
Chunjing Yang ◽  
Dan Xue ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Intranasal Administration ◽  
Protective Effects ◽  
Brain Distribution ◽  
Ginsenoside Rd ◽  
Distribution Studies

Ginsenoside Rd was shown to have protective effects against several injuries and efficient for the treatment of acute ischemic stroke.

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