Pharmacokinetics and brain distribution studies of ginsenoside Rd in rats via intranasal administration by LC-MS/MS

2015 ◽  
Vol 7 (20) ◽  
pp. 8809-8816 ◽  
Author(s):  
Sali Cao ◽  
Xingbin Yin ◽  
Jing Fu ◽  
Chunjing Yang ◽  
Dan Xue ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Intranasal Administration ◽  
Protective Effects ◽  
Brain Distribution ◽  
Ginsenoside Rd ◽  
Distribution Studies

Ginsenoside Rd was shown to have protective effects against several injuries and efficient for the treatment of acute ischemic stroke.

Ginsenoside Rd Is Efficacious Against Acute Ischemic Stroke by Suppressing Microglial Proteasome-Mediated Inflammation

2015 ◽  
Vol 53 (4) ◽  
pp. 2529-2540 ◽  
Author(s):  
Guangyun Zhang ◽  
Feng Xia ◽  
Yunxia Zhang ◽  
Xiao Zhang ◽  
Yuhong Cao ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Ginsenoside Rd

scholarly journals High-Density Lipoprotein Therapy in Stroke: Evaluation of Endothelial SR-BI-Dependent Neuroprotective Effects

2020 ◽  
Vol 22 (1) ◽  
pp. 106
Author(s):  
Alexy Tran-Dinh ◽  
Angélique Levoye ◽  
David Couret ◽  
Lauriane Galle-Treger ◽  
Martine Moreau ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Infarct Volume ◽  
High Density ◽  
High Density Lipoproteins ◽  
Protective Effects ◽  
Neuroprotective Effects

High-density lipoproteins (HDLs) display endothelial protective effects. We tested the role of SR-BI, an HDL receptor expressed by endothelial cells, in the neuroprotective effects of HDLs using an experimental model of acute ischemic stroke. After transient intraluminal middle cerebral artery occlusion (tMCAO), control and endothelial SR-BI deficient mice were intravenously injected by HDLs or saline. Infarct volume and blood-brain barrier (BBB) breakdown were assessed 24 h post tMCAO. The potential of HDLs and the role of SR-BI to maintain the BBB integrity was assessed by using a human cellular model of BBB (hCMEC/D3 cell line) subjected to oxygen-glucose deprivation (OGD). HDL therapy limited the infarct volume and the BBB leakage in control mice relative to saline injection. Interestingly, these neuroprotective effects were thwarted by the deletion of SR-BI in endothelial cells and preserved in mice deficient for SR-BI in myeloid cells. In vitro studies revealed that HDLs can preserve the integrity of the BBB in OGD conditions, and that this effect was reduced by the SR-BI inhibitor, BLT-1. The protection of BBB integrity plays a pivotal role in HDL therapy of acute ischemic stroke. Our results show that this effect is partially mediated by the HDL receptor, SR-BI expressed by endothelial cells.

scholarly journals Dengzhanxixin Injection Ameliorates Cognitive Impairment Through a Neuroprotective Mechanism Based on Mitochondrial Preservation in Patients With Acute Ischemic Stroke

2021 ◽  
Vol 12 ◽  
Author(s):  
Haiting An ◽  
Wuhai Tao ◽  
Ying Liang ◽  
Peng Li ◽  
Min Li ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Cognitive Impairment ◽  
Acute Ischemic Stroke ◽  
Neuropsychological Tests ◽  
Grey Matter ◽  
Infarct Volume ◽  
Cognitive Impairments ◽  
Mitochondrial Respiratory Chain ◽  
Chain Process ◽  
Protective Effects

Acute ischemic stroke (AIS) is a global health burden and cognitive impairment is one of its most serious complication. Adequate interventions for AIS may have the potential to improve cognitive outcomes. In the present study, we selected Erigeron breviscapus (Vaniot) Hand.-Mazz. injection (Dengzhanxixin injection, DZXI), a widely used Chinese herbal injection, in contrast to edaravone as the positive control drug to test its potential to ameliorates neurological and cognitive impairments caused by AIS. We performed a 2-week randomized trial with these two drugs in AIS patients presenting mild to moderate cognitive impairments. Neuropsychological tests and MRI examinations showed that DZXI attenuated the neurological and cognitive impairments of patients and protected the grey matter in specific regions from ischemic damage. Notably, DZXI exerted better effects than edaravone in some neuropsychological tests, probably due to the protective effect of DZXI on grey matter. To explore the therapeutic mechanisms, we carried out an experiment with a middle cerebral artery occlusion rat model. We found that DZXI decreased the infarct volume and increased the survival of neuronal cells in the ischemic penumbra; furthermore, DZXI modulated the mitochondrial respiratory chain process and preserved the mitochondrial structure in the brain tissue. Overall, our data suggested that the administration of DZXI is effective at ameliorating neurological and cognitive impairments in AIS, and the underlying mechanisms are related to the protective effects of DZXI on cerebral neurons and neuronal mitochondria.

Ginsenoside Rd for acute ischemic stroke: translating from bench to bedside

2013 ◽  
Vol 13 (6) ◽  
pp. 603-613 ◽  
Author(s):  
Ruidong Ye ◽  
Gang Zhao ◽  
Xinfeng Liu
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Ginsenoside Rd
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