scholarly journals Protective Effects of Ginsenoside Rd on PC12 Cells against Hydrogen Peroxide

2008 ◽  
Vol 31 (10) ◽  
pp. 1923-1927 ◽  
Author(s):  
Ruidong Ye ◽  
Junliang Han ◽  
Xiangwei Kong ◽  
Lingzhou Zhao ◽  
Rong Cao ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Pc12 Cells ◽  
Protective Effects ◽  
Ginsenoside Rd

Antioxidant properties and protective effects of a standardized extract of Hypericum perforatum on hydrogen peroxide-induced oxidative damage in PC12 cells

Life Sciences ◽  
2004 ◽  
Vol 75 (10) ◽  
pp. 1263-1276 ◽  
Author(s):  
Juana Benedı́ ◽  
Rocio Arroyo ◽  
Carmen Romero ◽  
Sagrario Martı́n-Aragón ◽  
Angel M Villar
Keyword(s):  
Hydrogen Peroxide ◽  
Oxidative Damage ◽  
Pc12 Cells ◽  
Hypericum Perforatum ◽  
Antioxidant Properties ◽  
Protective Effects

Synthesis of cystine C60 derivative and its protective effects on hydrogen peroxide-induced apoptosis in PC12 cells

2007 ◽  
Vol 18 (2) ◽  
pp. 145-148 ◽  
Author(s):  
Zhen Hu ◽  
Hai Ping Xing ◽  
Zhou Zhu ◽  
Wei Wang ◽  
Wen Chao Guan
Keyword(s):  
Hydrogen Peroxide ◽  
Pc12 Cells ◽  
Protective Effects ◽  
Induced Apoptosis

Protective effects of the citrus flavanones to PC12 cells against cytotoxicity induced by hydrogen peroxide

2010 ◽  
Vol 484 (1) ◽  
pp. 6-11 ◽  
Author(s):  
Yan-hua Lu ◽  
Ming-yuan Su ◽  
Hai-ya Huang ◽  
Lin-Li ◽  
Cai-gen Yuan
Keyword(s):  
Hydrogen Peroxide ◽  
Pc12 Cells ◽  
Protective Effects

scholarly journals Protective Effects and Mechanism of Hyperoside in PC12 Cells Against Oxidative Stress Injury Induced by Hydrogen Peroxide

2021 ◽  
Vol 16 (5) ◽  
pp. 1934578X2110151
Author(s):  
Yan Feng ◽  
Dongxu Wang ◽  
Qi Wang ◽  
Zhifeng Li ◽  
Shi-Lin Yang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Neurodegenerative Diseases ◽  
Pc12 Cells ◽  
Neuronal Damage ◽  
Neuroprotective Effect ◽  
Natural Antioxidants ◽  
Protective Effects ◽  
Stress Injury ◽  
Stress Damage

As the aging phenomenon continues to increase, the incidence of neurodegenerative diseases continues to increase annually. As one of the significant contributive factors of neurodegenerative diseases, oxidative stress damage has received extensive attention in recent years. Oxidative stress plays an important role in neuronal damage through various apoptotic mechanisms related to neurodegenerative diseases. The use of natural antioxidants to combat oxidative stress may be a useful approach in delaying disease progression. In this study, we explored the neuroprotective effect of hyperoside on rat pheochromoma (PC12) cells. Specifically, the antioxidant effect and mechanism of hyperoside in hydrogen peroxide (H2O2)-induced cellular cytotoxicity were investigated. Our results showed that hyperoside could significantly increase the survival rate of rat PC12 cells when exposed to H2O2. In addition, hyperoside regulated the expression of genes and proteins in the corresponding pathways by up-regulating the phosphatidylinositol-3-kinase (PI3K), protein kinase B (Akt), and light chain 3β (LC3B) pathways and down-regulating the nuclear factor-ᴋ-gene binding (NF-κB), Bcl2-associated X (Bax), cysteinyl aspartate specific proteinase 3 (Caspase 3), and P62 pathways, thereby inhibiting cell apoptosis. Therefore, hyperoside can effectively inhibit H2O2-induced oxidative stress damage by regulating inflammation, autophagy, and apoptosis-related pathways.

Potential mechanisms mediating the protective effects of a peptide from walnut (Juglans mandshuricaMaxim.) against hydrogen peroxide induced neurotoxicity in PC12 cells

2019 ◽  
Vol 10 (6) ◽  
pp. 3491-3501 ◽  
Author(s):  
Chunlei Liu ◽  
Yong Guo ◽  
Fanrui Zhao ◽  
Hanxiong Qin ◽  
Hongyan Lu ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Pc12 Cells ◽  
Protein Hydrolysates ◽  
Protective Effects

A novel neuroprotective peptide EVSGPGLSPN, which was identified from walnut protein hydrolysates, protected PC12 cells by blocking the NF-κB/caspase pathways.

The protective effects of oxyresveratrol imine derivative against hydrogen peroxide-induced cell death in PC12 cells

2013 ◽  
Vol 47 (3) ◽  
pp. 212-218 ◽  
Author(s):  
J. Hur ◽  
S. Kim ◽  
P. Lee ◽  
Y. M. Lee ◽  
S. Y. Choi
Keyword(s):  
Hydrogen Peroxide ◽  
Cell Death ◽  
Pc12 Cells ◽  
Protective Effects
Sign in / Sign up

Export Citation Format

Share Document