scholarly journals The Effect of Chemical Structure of OEG Ligand Shells with Quaternary Ammonium Moiety on the Colloidal Stabilization, Cellular Uptake and Photothermal Stability of Gold Nanorods

2021 ◽  
Vol Volume 16 ◽  
pp. 3407-3427
Author(s):  
Sarka Salajkova ◽  
Filip Havel ◽  
Michal Sramek ◽  
Filip Novotny ◽  
David Malinak ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Gold Nanorods ◽  
Quaternary Ammonium ◽  
Chemical Structure

Systematic Characterization of Different Quaternary Ammonium Salts to be Used in Organoclays

2012 ◽  
Vol 727-728 ◽  
pp. 1552-1556
Author(s):  
Renata Barbosa ◽  
Dayanne Diniz Souza ◽  
Edcleide Maria Araújo ◽  
Tomás Jefférson Alves de Mélo
Keyword(s):  
Thermal Stability ◽  
Quaternary Ammonium ◽  
Chemical Structure ◽  
Quaternary Ammonium Salts ◽  
Ammonium Salts ◽  
Degradation Mechanisms ◽  
Scanning Calorimetry ◽  
Higher Temperature ◽  
Thermal Stability Of

Studies of degradation have verified that the decomposition of some quaternary ammonium salts can begin to be significant at the temperature of about 180 ° C and like most thermoplastics are processed at least around this temperature, the thermal stability of the salt in clay should always be considered. Some salts are more stable than others, being necessary to study the degradation mechanisms of each case. In this work, four quaternary ammonium salts were characterized by differential scanning calorimetry (DSC) and thermogravimetry (TG). The results of DSC and TG showed that the salts based chloride (Cl-) anion begin to degrade at similar temperatures, while the salt based bromide (Br-) anion degrades at higher temperature. Subsequently, a quaternary ammonium salt was chosen to be used in organoclays, depending on its chemical structure and its thermal behavior.

Cellular Uptake and Cytotoxicity of Varying Aspect Ratios of Gold Nanorods in HeLa Cells

2020 ◽  
Vol 3 (3) ◽  
pp. 1374-1384 ◽  
Author(s):  
Deshani Fernando ◽  
Shoukath Sulthana ◽  
Yolanda Vasquez
Keyword(s):  
Cellular Uptake ◽  
Gold Nanorods ◽  
Hela Cells ◽  
Aspect Ratios

Surface modification of gold nanorods using layer-by-layer technique for cellular uptake

2007 ◽  
Vol 10 (1) ◽  
pp. 221-228 ◽  
Author(s):  
Hironobu Takahashi ◽  
Takuro Niidome ◽  
Takahito Kawano ◽  
Sunao Yamada ◽  
Yasuro Niidome
Keyword(s):  
Surface Modification ◽  
Cellular Uptake ◽  
Gold Nanorods ◽  
Layer By Layer ◽  
Layer Technique ◽  
Layer By Layer Technique

Cellular uptake of polyurethane nanocarriers mediated by gemini quaternary ammonium

Biomaterials ◽  
2011 ◽  
Vol 32 (35) ◽  
pp. 9515-9524 ◽  
Author(s):  
Mingming Ding ◽  
Xueling He ◽  
Zhigao Wang ◽  
Jiehua Li ◽  
Hong Tan ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Quaternary Ammonium

scholarly journals Azo-polysiloxane micelles charged with nifedipine

2013 ◽  
Vol 11 (9) ◽  
pp. 1431-1438 ◽  
Author(s):  
Anca-Irina Prisacaru ◽  
Silvia Grama ◽  
Ana Durdureanu-Angheluta ◽  
Mariana Pinteala ◽  
Nicolae Hurduc
Keyword(s):  
Drug Delivery ◽  
Quaternary Ammonium ◽  
Drug Delivery Systems ◽  
Chemical Structure ◽  
Research Study ◽  
Critical Concentration ◽  
Embedding Capacity ◽  
Photosensitive Polymers ◽  
Optimum Range ◽  
External Stimuli

AbstractAbstract One recent aspect of the research study on polymers is their capability to respond to external stimuli. Of importance are photosensitive polymers due to their application in drug delivery systems, sensors, therapeutic devices or optoelectronic switches. The present paper focuses on the azo-polysiloxane micelles capacity charged with hydrophobic drugs, such as nifedipine. Azo-polysiloxanes modified with quaternary ammonium groups and which are capable to generate photo-sensitive micelles were synthesized and characterized by 1H-NMR, UV-VIS and fluorescence spectroscopy. The critical concentration of the micellar aggregation (CCA) was evaluated as was the nifedipine embedding capacity. The CCA values were influenced only by the hydrophobic/hydrophilic balance and not by the chemical structure of the quaternary ammonium groups. The disaggregation capacity of the micelles under UV irradiation was investigated as well, and the best results were obtained for the samples with higher azobenzene content. The DLS measurements evidenced micelles diameters situated in the optimum range domain (70–130 nm). The capacity to incorporate nifedipine inside the micelles was demonstrated. The micelles proved to be stable in time, 21 days after preparation with the diameter having constant values. Graphical abstract

Synthesis of Gold Nanoparticles Coated with pH-Responsive Polymers and Evaluation of the Cellular Uptake

2012 ◽  
Vol 1416 ◽  
Author(s):  
Takeo Ito ◽  
Eriko Kusaka ◽  
Yu Isobe ◽  
Sei-ichi Nishimoto
Keyword(s):  
Cellular Uptake ◽  
Gold Nanorods ◽  
Near Infrared ◽  
A549 Cells ◽  
Endocytic Pathway ◽  
Human Lung Cancer ◽  
Ph Responsive ◽  
Absorption Bands ◽  
Responsive Polymers ◽  
Ph Responsive Polymers

ABSTRACTGold nanorods (AuNRs) show surface plasmon absorption bands in the near-infrared region. This characteristic property has stimulated utilization of gold nanorods as novel nanoprobes for noninvasive bioimaging, such as photoacoustic tomography. Herein, we discuss the synthesis of a series of gold nanorods coated with pH-responsive polymers to investigate the effect of the surface structure and zeta potential of nanoparticles on cellular uptake via a surface charge-mediated endocytic pathway. The surface of the gold nanorods was modified with polyethylene glycol (PEG@AuNR) and tertiary amine derivatives, specifically, diethylaminoethyl ester (1@AuNRs), its amide analog (2@AuNRs), and dimethylaminoethyl ester (3@AuNRs). It was found that the pH-sensitivity of1@AuNRs was relatively high and the surface was positively charged at lower pH. In contrast, the tertiary amino group of1@AuNRs was deprotonated to form an electrostatically neutral surface at higher pH. The pH-responsive gold nanorods were incubated with A549 cells (human lung cancer cells) to quantify the amount of cellular uptake using inductively coupled plasma mass spectrometry. The results indicate that1@AuNRs can be taken up efficiently in the cells, and thereafter, slowly flow out of the cells. Interestingly, only small amounts of the amide analog (2@AuNRs) were taken into the cells, suggesting minor structural changes may affect the interaction between the cell surface and AuNRs. This study highlights a potential application of pH-sensitive nanorods as a probe for bioimaging the acidic environment of tumors.

The influence of cellular uptake on gold nanorods photostability and photoacoustic conversion efficiency

2015 ◽  
Author(s):  
Lucia Cavigli ◽  
Fulvio Ratto ◽  
Francesca Tatini ◽  
Paolo Matteini ◽  
Alberto Cini ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Conversion Efficiency ◽  
Gold Nanorods

scholarly journals Interaction of Gold Nanorods with Human Dermal Fibroblasts: Cytotoxicity, Cellular Uptake, and Wound Healing

Nanomaterials ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. 1131
Author(s):  
Nouf N. Mahmoud ◽  
Lubna M. Al-Kharabsheh ◽  
Enam A. Khalil ◽  
Rana Abu-Dahab
Keyword(s):  
Wound Healing ◽  
Cellular Uptake ◽  
Gold Nanorods ◽  
Healing Rate ◽  
Scratch Test ◽  
Dermal Fibroblasts ◽  
Human Dermal Fibroblasts ◽  
Poly Ethylene ◽  
Wound Healing Rate

Herein, the cytotoxicity, cellular uptake and wound healing of human dermal fibroblasts were investigated upon treatment with gold nanorods (GNR) decorated with different ligands. Neutral and cationic poly ethylene glycol (PEG)-decorated GNR demonstrated the least cytotoxicity and cellular internalization, while anionic- and bovine serum albumin (BSA)-coated GNR revealed significant cytotoxicity and cellular uptake into human dermal fibroblasts. The cell scratch test demonstrated that neutral, cationic PEGylated GNR and anionic-decorated GNR have accelerated the wound healing rate in vitro after 24 h of incubation with scratched human dermal fibroblasts compared to control, while there was a drastic retardation of wound healing rate of scratched fibroblasts upon exposure to BSA-GNR accompanied with a significant release of the inflammatory cytokine; interlukin-1β (IL-1β). The cytotoxicity of GNR against the dermal cells and their ability to enhance the wound healing in vitro are greatly linked to their surface modifications.

Mechanism for the Cellular Uptake of Targeted Gold Nanorods of Defined Aspect Ratios

Small ◽  
2016 ◽  
Vol 12 (37) ◽  
pp. 5178-5189 ◽  
Author(s):  
Hongrong Yang ◽  
Zhong Chen ◽  
Lei Zhang ◽  
Wing-Yin Yung ◽  
Ken Cham-Fai Leung ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Gold Nanorods ◽  
Aspect Ratios
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