The influence of cellular uptake on gold nanorods photostability and photoacoustic conversion efficiency

2015 ◽  
Author(s):  
Lucia Cavigli ◽  
Fulvio Ratto ◽  
Francesca Tatini ◽  
Paolo Matteini ◽  
Alberto Cini ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Conversion Efficiency ◽  
Gold Nanorods

Cellular Uptake and Cytotoxicity of Varying Aspect Ratios of Gold Nanorods in HeLa Cells

2020 ◽  
Vol 3 (3) ◽  
pp. 1374-1384 ◽  
Author(s):  
Deshani Fernando ◽  
Shoukath Sulthana ◽  
Yolanda Vasquez
Keyword(s):  
Cellular Uptake ◽  
Gold Nanorods ◽  
Hela Cells ◽  
Aspect Ratios

Surface modification of gold nanorods using layer-by-layer technique for cellular uptake

2007 ◽  
Vol 10 (1) ◽  
pp. 221-228 ◽  
Author(s):  
Hironobu Takahashi ◽  
Takuro Niidome ◽  
Takahito Kawano ◽  
Sunao Yamada ◽  
Yasuro Niidome
Keyword(s):  
Surface Modification ◽  
Cellular Uptake ◽  
Gold Nanorods ◽  
Layer By Layer ◽  
Layer Technique ◽  
Layer By Layer Technique

Synthesis of Gold Nanoparticles Coated with pH-Responsive Polymers and Evaluation of the Cellular Uptake

2012 ◽  
Vol 1416 ◽  
Author(s):  
Takeo Ito ◽  
Eriko Kusaka ◽  
Yu Isobe ◽  
Sei-ichi Nishimoto
Keyword(s):  
Cellular Uptake ◽  
Gold Nanorods ◽  
Near Infrared ◽  
A549 Cells ◽  
Endocytic Pathway ◽  
Human Lung Cancer ◽  
Ph Responsive ◽  
Absorption Bands ◽  
Responsive Polymers ◽  
Ph Responsive Polymers

ABSTRACTGold nanorods (AuNRs) show surface plasmon absorption bands in the near-infrared region. This characteristic property has stimulated utilization of gold nanorods as novel nanoprobes for noninvasive bioimaging, such as photoacoustic tomography. Herein, we discuss the synthesis of a series of gold nanorods coated with pH-responsive polymers to investigate the effect of the surface structure and zeta potential of nanoparticles on cellular uptake via a surface charge-mediated endocytic pathway. The surface of the gold nanorods was modified with polyethylene glycol (PEG@AuNR) and tertiary amine derivatives, specifically, diethylaminoethyl ester (1@AuNRs), its amide analog (2@AuNRs), and dimethylaminoethyl ester (3@AuNRs). It was found that the pH-sensitivity of1@AuNRs was relatively high and the surface was positively charged at lower pH. In contrast, the tertiary amino group of1@AuNRs was deprotonated to form an electrostatically neutral surface at higher pH. The pH-responsive gold nanorods were incubated with A549 cells (human lung cancer cells) to quantify the amount of cellular uptake using inductively coupled plasma mass spectrometry. The results indicate that1@AuNRs can be taken up efficiently in the cells, and thereafter, slowly flow out of the cells. Interestingly, only small amounts of the amide analog (2@AuNRs) were taken into the cells, suggesting minor structural changes may affect the interaction between the cell surface and AuNRs. This study highlights a potential application of pH-sensitive nanorods as a probe for bioimaging the acidic environment of tumors.

scholarly journals Interaction of Gold Nanorods with Human Dermal Fibroblasts: Cytotoxicity, Cellular Uptake, and Wound Healing

Nanomaterials ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. 1131
Author(s):  
Nouf N. Mahmoud ◽  
Lubna M. Al-Kharabsheh ◽  
Enam A. Khalil ◽  
Rana Abu-Dahab
Keyword(s):  
Wound Healing ◽  
Cellular Uptake ◽  
Gold Nanorods ◽  
Healing Rate ◽  
Scratch Test ◽  
Dermal Fibroblasts ◽  
Human Dermal Fibroblasts ◽  
Poly Ethylene ◽  
Wound Healing Rate

Herein, the cytotoxicity, cellular uptake and wound healing of human dermal fibroblasts were investigated upon treatment with gold nanorods (GNR) decorated with different ligands. Neutral and cationic poly ethylene glycol (PEG)-decorated GNR demonstrated the least cytotoxicity and cellular internalization, while anionic- and bovine serum albumin (BSA)-coated GNR revealed significant cytotoxicity and cellular uptake into human dermal fibroblasts. The cell scratch test demonstrated that neutral, cationic PEGylated GNR and anionic-decorated GNR have accelerated the wound healing rate in vitro after 24 h of incubation with scratched human dermal fibroblasts compared to control, while there was a drastic retardation of wound healing rate of scratched fibroblasts upon exposure to BSA-GNR accompanied with a significant release of the inflammatory cytokine; interlukin-1β (IL-1β). The cytotoxicity of GNR against the dermal cells and their ability to enhance the wound healing in vitro are greatly linked to their surface modifications.

Mechanism for the Cellular Uptake of Targeted Gold Nanorods of Defined Aspect Ratios

Small ◽  
2016 ◽  
Vol 12 (37) ◽  
pp. 5178-5189 ◽  
Author(s):  
Hongrong Yang ◽  
Zhong Chen ◽  
Lei Zhang ◽  
Wing-Yin Yung ◽  
Ken Cham-Fai Leung ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Gold Nanorods ◽  
Aspect Ratios

scholarly journals Toxicity and Cellular Uptake of Gold Nanorods in Vascular Endothelium and Smooth Muscles of Isolated Rat Blood Vessel: Importance of Surface Modification

Small ◽  
2012 ◽  
Vol 8 (8) ◽  
pp. 1270-1278 ◽  
Author(s):  
Alaaldin M. Alkilany ◽  
Alia Shatanawi ◽  
Timothy Kurtz ◽  
Ruth B. Caldwell ◽  
R. William Caldwell
Keyword(s):  
Surface Modification ◽  
Blood Vessel ◽  
Cellular Uptake ◽  
Gold Nanorods ◽  
Vascular Endothelium ◽  
Smooth Muscles ◽  
Rat Blood ◽  
Isolated Rat

Time evolution and dynamic cellular uptake of PEGYlated gold nanorods

RSC Advances ◽  
2016 ◽  
Vol 6 (10) ◽  
pp. 8089-8092 ◽  
Author(s):  
Hongyuan Song ◽  
Qingqiang Xu ◽  
Hongwei Di ◽  
Ting Guo ◽  
Zhongtian Qi ◽  
...  
Keyword(s):  
Time Evolution ◽  
Cellular Uptake ◽  
Gold Nanorods ◽  
Protein Corona

The protein corona formed and evolved of PEGYlated GNRs which alter GNRs characteristics significantly leading to dynamic cellular uptake pathways.

Gold nanoparticles impair autophagy flux through shape-dependent endocytosis and lysosomal dysfunction

2018 ◽  
Vol 6 (48) ◽  
pp. 8127-8136 ◽  
Author(s):  
Hualu Zhou ◽  
Xuanqing Gong ◽  
Hongyu Lin ◽  
Hongming Chen ◽  
Dengtong Huang ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Cellular Uptake ◽  
Gold Nanorods ◽  
Gold Nanospheres ◽  
Autophagy Flux ◽  
Lysosomal Dysfunction

Gold nanospheres stimulate more autophagosome accumulation than gold nanorods due to their higher efficiency of cellular uptake.

Cellular Uptake and Intra-Organ Biodistribution of Functionalized Silica-Coated Gold Nanorods

2016 ◽  
Vol 18 (5) ◽  
pp. 667-676 ◽  
Author(s):  
Bin Gao ◽  
Jun Xu ◽  
ke-wu He ◽  
Lei Shen ◽  
Hao Chen ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Gold Nanorods ◽  
Functionalized Silica
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