scholarly journals Metabolic Fate of Human Urinary Kallidinogenase(SK-827) (2): Distribution, Accumulation and Urinary or Biliary Excretion in Rats after Single or Repeated Intravenous Administration.

1994 ◽  
Vol 9 (1) ◽  
pp. 15-39
Author(s):  
Yukiharu NAKAYAMA ◽  
Yasutomi MITOH ◽  
Yoshiyuki FURUTA ◽  
Akihiro SOBUE ◽  
Tsuneaki INOUE ◽  
...  
Keyword(s):  
Intravenous Administration ◽  
Biliary Excretion ◽  
Metabolic Fate

Transhepatic absorption and biliary excretion of insulin

1987 ◽  
Vol 65 (9) ◽  
pp. 1982-1987 ◽  
Author(s):  
Walter Zingg ◽  
Aron M. Rappaport ◽  
Bernard S. Leibel
Keyword(s):  
Intravenous Administration ◽  
Biliary Excretion ◽  
Venous Blood ◽  
Intraperitoneal Administration ◽  
Liver Cells ◽  
Insulin Concentration ◽  
Secretory Process ◽  
Insulin Administration ◽  
Hepatic Cells ◽  
Liver Surface

The application of insulin to the liver in rats is followed by an increase of the insulin concentration in the bile. The pathway of insulin from the liver surface to the bile may include a secretory process by the hepatic cells, or it may bypass the hepatic cells, using direct anatomical pathways from blood and lymph to bile. The concentration of insulin in arterial and venous blood, in lymph, and in bile was measured following application of insulin to the liver surface and following peritoneal or intravenous administration. The results confirm that insulin is absorbed from the surface of the liver, but the glucose modulating effect was less effective than after intravenous administration. The insulin concentration in bile was increased after insulin administration by all routes, with the highest and most prolonged increases found after intraperitoneal administration. The results suggest that following transhepatic and intravenous administration, insulin reaches the bile without passing through the liver cells.

scholarly journals Studies on the Metabolic Fate of Flecainide Acetate. (1). Blood Levels, Distribution, Metabolism and Excretion in Rats after Repeated Intravenous Administration.

1999 ◽  
Vol 14 (3) ◽  
pp. 201-213
Author(s):  
Mannen MISHIMA ◽  
Masataka UEDA ◽  
Atsushi TAKAO ◽  
Atsuhiro INABA ◽  
Keiko KAMIYA ◽  
...  
Keyword(s):  
Intravenous Administration ◽  
Blood Levels ◽  
Metabolic Fate ◽  
Flecainide Acetate

Biliary excretion of radioactivity after intravenous administration of [3H]25-hydroxyvitamin D3 in man

1986 ◽  
Vol 31 (4) ◽  
pp. 361-368 ◽  
Author(s):  
Julia E. Ledger ◽  
Graham J. Watson ◽  
Juliet E. Compston
Keyword(s):  
Intravenous Administration ◽  
Biliary Excretion
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