Metabolic fate of recombinant human tissue plasminogen activator(rt-PA). (1): Blood or plasma concentration, distribution, metabolism and excretion in rats after single intravenous administration.

Seiu IIDA; Masato IWAMOTO; Masayuki SUZUKI; Noriko HISANAGA; Naoki TSUJII; Teiko KOMATSU

doi:10.2133/dmpk.3.309

Metabolic fate of recombinant human tissue plasminogen activator(rt-PA). (1): Blood or plasma concentration, distribution, metabolism and excretion in rats after single intravenous administration.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.3.309 ◽

1988 ◽

Vol 3 (3) ◽

pp. 309-329 ◽

Cited By ~ 1

Author(s):

Seiu IIDA ◽

Masato IWAMOTO ◽

Masayuki SUZUKI ◽

Noriko HISANAGA ◽

Naoki TSUJII ◽

...

Keyword(s):

Plasma Concentration ◽

Plasminogen Activator ◽

Tissue Plasminogen Activator ◽

Intravenous Administration ◽

Human Tissue ◽

Concentration Distribution ◽

Metabolic Fate ◽

Tissue Plasminogen ◽

Single Intravenous Administration

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Metabolic fate of recombinant human tissue plasminogen activator(rt-PA). (2): Blood or plasma concentration, distribution, metabolism, excretion and accumulation in rats after repeated intravenous administration.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.3.331 ◽

1988 ◽

Vol 3 (3) ◽

pp. 331-347

Author(s):

Seiu IIDA ◽

Masato IWAMOTO ◽

Masayuki SUZUKI ◽

Noriko HISANAGA ◽

Teiko KOMATSU

Keyword(s):

Plasma Concentration ◽

Plasminogen Activator ◽

Tissue Plasminogen Activator ◽

Intravenous Administration ◽

Human Tissue ◽

Concentration Distribution ◽

Metabolic Fate ◽

Tissue Plasminogen

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Studies on the Metabolic Fate of Modified Recombinant Tissue-Type Plasminogen Activator (E6010) (1): Blood or Plasma Concentration, Distribution, Metabolism and Excretion in Rats after a Single Intravenous Administration of l25I-E6010 in Comparison with l25I-Recombinant Tissue-Type Plasminogen Activator (rt-PA).

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.11.556 ◽

1996 ◽

Vol 11 (6) ◽

pp. 556-584

Author(s):

Hitoshi Mizuo ◽

Takayuki SEKO ◽

Koichi NOSE ◽

Tomomi ANDO ◽

Yoshiko KAGEI ◽

...

Keyword(s):

Plasma Concentration ◽

Plasminogen Activator ◽

Intravenous Administration ◽

Concentration Distribution ◽

Tissue Type ◽

Metabolic Fate ◽

Tissue Type Plasminogen Activator ◽

Type Plasminogen Activator ◽

Single Intravenous Administration

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Metabolic Fate of 4-amino-1-hydroxybutylidene-1,1-bisphosphonate(alendronate). (II). Plasma Concentration, Distribution and Excretion after Repeated Intravenous Administration to 7-week Old Rats and after Single Intravenous Administration to 30-week Old Rats, and Transfer into the Fetus and Milk in Rats.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.10.174 ◽

1995 ◽

Vol 10 (2) ◽

pp. 174-189 ◽

Cited By ~ 3

Author(s):

Tsutomu MOCHIZUKI ◽

Shin-ichi NISHIMURA ◽

Koichiro OKABE ◽

Yoshiaki AZUMA ◽

Shin UMEDA ◽

...

Keyword(s):

Plasma Concentration ◽

Intravenous Administration ◽

Concentration Distribution ◽

Metabolic Fate ◽

Old Rats ◽

Single Intravenous Administration

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Studies on the Metabolic Fate of Modified Recombinant Tissu-Type Plasminogen Activator (E6010) (2): Blood or Plasma Concentration, Distribution, Metabolism and Excretion in Rats after Repeated Intravenous Administration of 125I-E6010.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.11.585 ◽

1996 ◽

Vol 11 (6) ◽

pp. 585-598

Author(s):

Hitoshi Mizuo ◽

Kiyomi KIKUCHI ◽

Mannen MISHIMA ◽

Masataka UEDA ◽

Teruaki YUZURIHA

Keyword(s):

Plasma Concentration ◽

Plasminogen Activator ◽

Intravenous Administration ◽

Concentration Distribution ◽

Metabolic Fate ◽

Type Plasminogen Activator

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Metabolic Fate of YM866, a Novel Fibrinolytic Agent (I). Plasma Concentration, Distribution, Metabolism and Excretion in Rats after Single Intravenous Administration.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.11.1 ◽

1996 ◽

Vol 11 (1) ◽

pp. 1-10

Author(s):

Keishi OIKAWA ◽

Hidetaka KAMIMURA ◽

Takashi WATANABE ◽

Ikuo MIYAMOTO ◽

Saburo HIGUCHI

Keyword(s):

Plasma Concentration ◽

Intravenous Administration ◽

Concentration Distribution ◽

Metabolic Fate ◽

Fibrinolytic Agent ◽

Single Intravenous Administration

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Novel biomimetic affinity ligands for human tissue plasminogen activator

Biochemical and Biophysical Research Communications ◽

10.1016/j.bbrc.2007.02.007 ◽

2007 ◽

Vol 355 (3) ◽

pp. 673-678 ◽

Cited By ~ 9

Author(s):

Fang Wu ◽

Jing Yu

Keyword(s):

Plasminogen Activator ◽

Tissue Plasminogen Activator ◽

Human Tissue ◽

Affinity Ligands ◽

Tissue Plasminogen

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A polymorphic dinucleotide repeat in intron 1 of the human tissue plasminogen activator gene

Human Molecular Genetics ◽

10.1093/hmg/1.2.138-a ◽

1992 ◽

Vol 1 (2) ◽

pp. 138-138 ◽

Cited By ~ 2

Author(s):

W. Thomas ◽

D. Drayna

Keyword(s):

Plasminogen Activator ◽

Tissue Plasminogen Activator ◽

Human Tissue ◽

Dinucleotide Repeat ◽

Intron 1 ◽

Polymorphic Dinucleotide Repeat ◽

Tissue Plasminogen ◽

Polymorphic Dinucleotide

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In silico and in vivo analyses of the mutated human tissue plasminogen activator (mtPA) and the antithetical effects of P19 silencing suppressor on its expression in two Nicotiana species

Scientific Reports ◽

10.1038/s41598-018-32099-6 ◽

2018 ◽

Vol 8 (1) ◽

Author(s):

Mahshid Amiri ◽

Mokhtar Jalali-Javaran ◽

Raheem Haddad ◽

Parastoo Ehsani

Keyword(s):

Plasminogen Activator ◽

Tissue Plasminogen Activator ◽

Human Tissue ◽

In Silico ◽

Silencing Suppressor ◽

Nicotiana Species ◽

Tissue Plasminogen

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Retroviral Vector-Mediated Transfer and Expression of Human Tissue Plasminogen Activator cDNA in Bovine Brain Endothelial Cells

Neurosurgery ◽

10.1097/00006123-199910000-00072 ◽

1999 ◽

Vol 45 (4) ◽

pp. 962-970 ◽

Cited By ~ 7

Author(s):

Hong Yu ◽

Ying Wang ◽

Darwin Eton ◽

Monique Stins ◽

Liang Wang ◽

...

Keyword(s):

Endothelial Cells ◽

Plasminogen Activator ◽

Tissue Plasminogen Activator ◽

Human Tissue ◽

Retroviral Vector ◽

Bovine Brain ◽

Brain Endothelial Cells ◽

Tissue Plasminogen

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Intracranial hemorrhage after intravenous administration of tissue plasminogen activator in a patient with acute ischemic stroke: case report

Nosotchu ◽

10.3995/jstroke.10567 ◽

2019 ◽

Vol 41 (2) ◽

pp. 106-110

Author(s):

Yasufumi Inaka ◽

Kenichiro Ono ◽

Hiroaki Kobayashi ◽

Takashi Takahara ◽

Hidenori Okawa ◽

...

Keyword(s):

Ischemic Stroke ◽

Case Report ◽

Acute Ischemic Stroke ◽

Plasminogen Activator ◽

Tissue Plasminogen Activator ◽

Intracranial Hemorrhage ◽

Intravenous Administration ◽

Tissue Plasminogen ◽

Stroke Case

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