Plasma pharmacokinetics and urinary and biliary excretion of a new potent tripeptide HIV-1 protease inhibitor, KNI-272, in rats after intravenous administration

1994 ◽  
Vol 15 (7) ◽  
pp. 617-626 ◽  
Author(s):  
A. Kiriyama ◽  
K. Fujita ◽  
S. Takemura ◽  
H. Kuramoto ◽  
Y. Kiso ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
Intravenous Administration ◽  
Biliary Excretion ◽  
Plasma Pharmacokinetics ◽  
Hiv 1

scholarly journals Simplification Therapy with Once‐Daily Emtricitabine, Didanosine, and Efavirenz in HIV‐1–Infected Adults with Viral Suppression Receiving a Protease Inhibitor–Based Regimen: A Randomized Trial

2005 ◽  
Vol 191 (6) ◽  
pp. 830-839 ◽  
Author(s):  
Jean‐Michel Molina ◽  
Valérie Journot ◽  
Laurence Morand‐Joubert ◽  
Patrick Yéni ◽  
Willy Rozenbaum ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
Randomized Trial ◽  
Viral Suppression ◽  
Once Daily ◽  
Hiv 1

Transhepatic absorption and biliary excretion of insulin

1987 ◽  
Vol 65 (9) ◽  
pp. 1982-1987 ◽  
Author(s):  
Walter Zingg ◽  
Aron M. Rappaport ◽  
Bernard S. Leibel
Keyword(s):  
Intravenous Administration ◽  
Biliary Excretion ◽  
Venous Blood ◽  
Intraperitoneal Administration ◽  
Liver Cells ◽  
Insulin Concentration ◽  
Secretory Process ◽  
Insulin Administration ◽  
Hepatic Cells ◽  
Liver Surface

The application of insulin to the liver in rats is followed by an increase of the insulin concentration in the bile. The pathway of insulin from the liver surface to the bile may include a secretory process by the hepatic cells, or it may bypass the hepatic cells, using direct anatomical pathways from blood and lymph to bile. The concentration of insulin in arterial and venous blood, in lymph, and in bile was measured following application of insulin to the liver surface and following peritoneal or intravenous administration. The results confirm that insulin is absorbed from the surface of the liver, but the glucose modulating effect was less effective than after intravenous administration. The insulin concentration in bile was increased after insulin administration by all routes, with the highest and most prolonged increases found after intraperitoneal administration. The results suggest that following transhepatic and intravenous administration, insulin reaches the bile without passing through the liver cells.

HIV Production from Purified Monocytes Isolated from Antiretroviral-NaÏve and Protease Inhibitor-Treated HIV-1--Infected Patients

2002 ◽  
Vol 3 (6) ◽  
pp. 469-474 ◽  
Author(s):  
Kazanjian Powel ◽  
Adams Donna ◽  
Tate Stacey ◽  
Newman Gale
Keyword(s):  
Protease Inhibitor ◽  
Hiv 1

A Novel Nonpeptide HIV-1 Protease Inhibitor: Elucidation of the Binding Mode and Its Application in the Design of Related Analogs

1994 ◽  
Vol 37 (17) ◽  
pp. 2664-2677 ◽  
Author(s):  
Elizabeth A. Lunney ◽  
Susan E. Hagen ◽  
John M. Domagala ◽  
Christine Humblet ◽  
Janet Kosinski ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
Binding Mode ◽  
Hiv 1
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